Galactan induces macrophage M0 to M1 conversion to combat colon cancer

A 3-O-methylated-galactan WCCP-N-b from Cantharellus cibarius polarizes RAW264.7 macrophages, bone marrow-derived macrophages (BMDMs), and peritoneal macrophages (PEMs) leading to enhanced secretion of cytokine TNF-α and subsequent cytotoxic effects on HCT116 and CT26 colon cancer cells. Investigati...

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Published inFood Science and Technology Research Vol. 30; no. 1; pp. 75 - 82
Main Authors Meng, Yue, Yang, Guang, Ren, Ai, Qu, Yunhe, Wang, Xue, Mayo, Kevin H., Zhou, Yifa, Song, Chengcheng
Format Journal Article
LanguageEnglish
Published Tsukuba Japanese Society for Food Science and Technology 2024
Japan Science and Technology Agency
Subjects
antitumor effect
Bone marrow
Cantharellus cibarius
Colon cancer
Colorectal cancer
Cytotoxicity
galactan
Macrophages
NF-κB protein
Toll-like receptors
Tumor necrosis factor-α
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Abstract A 3-O-methylated-galactan WCCP-N-b from Cantharellus cibarius polarizes RAW264.7 macrophages, bone marrow-derived macrophages (BMDMs), and peritoneal macrophages (PEMs) leading to enhanced secretion of cytokine TNF-α and subsequent cytotoxic effects on HCT116 and CT26 colon cancer cells. Investigation into the mechanism of action suggests that WCCP-N-b polarizes macrophages by targeting Toll-like receptor 2 and activation of MAPKs and NF-κB signaling pathways. Overall, our results indicate that this linear 3-O-methylated-galactan inhibits colon cancer cells via conversion of M0 to M1 macrophages.
AbstractList A 3-O-methylated-galactan WCCP-N-b from Cantharellus cibarius polarizes RAW264.7 macrophages, bone marrow-derived macrophages (BMDMs), and peritoneal macrophages (PEMs) leading to enhanced secretion of cytokine TNF-α and subsequent cytotoxic effects on HCT116 and CT26 colon cancer cells. Investigation into the mechanism of action suggests that WCCP-N-b polarizes macrophages by targeting Toll-like receptor 2 and activation of MAPKs and NF-κB signaling pathways. Overall, our results indicate that this linear 3-O-methylated-galactan inhibits colon cancer cells via conversion of M0 to M1 macrophages.
ArticleNumber FSTR-D-23-00039
Author Wang, Xue
Yang, Guang
Song, Chengcheng
Meng, Yue
Ren, Ai
Qu, Yunhe
Mayo, Kevin H.
Zhou, Yifa
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SubjectTerms antitumor effect
Bone marrow
Cantharellus cibarius
Colon cancer
Colorectal cancer
Cytotoxicity
galactan
Macrophages
NF-κB protein
Toll-like receptors
Tumor necrosis factor-α
Title Galactan induces macrophage M0 to M1 conversion to combat colon cancer
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