Apparent Lack of Benefit of Combining Repetitive Transcranial Magnetic Stimulation with Internet-Delivered Cognitive Behavior Therapy for the Treatment of Resistant Depression: Patient-Centered Randomized Controlled Pilot Trial

• Published in: Brain sciences Vol. 13; no. 2; p. 293
• Main Authors: Adu, Medard Kofi, Shalaby, Reham, Eboreime, Ejemai, Sapara, Adegboyega, Lawal, Mobolaji A, Chew, Corina, Daubert, Shelley, Urichuck, Liana, Surood, Shireen, Li, Daniel, Snaterse, Mark, Mach, Mike, Chue, Pierre, Greenshaw, Andrew J, Agyapong, Vincent I O
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.02.2023; MDPI
• Subjects: Antidepressants; Behavior modification; Behavior therapy; Behavioral health care; Brain research; Care and treatment; Clinical medicine; Clinical trials; Cognition & reasoning; Cognitive ability; Cognitive behavioral therapy; Cognitive therapy; Comparative analysis; Depression, Mental; Evidence-based medicine; Health aspects; Internet; internet-based cognitive behavioral therapy; Magnetic fields; major depressive disorder; Medical research; Medicine, Experimental; Mental depression; Mental disorders; MoodGYM; Patient compliance; Patients; Population studies; Psychotherapy; repetitive transcranial magnetic stimulation; Suicidal behavior; Suicide; Suicides & suicide attempts; Therapists; Therapy; Transcranial magnetic stimulation; treatment-resistant depression; Alberta; MoodGYM; treatment-resistant depression; major depressive disorder; internet-based cognitive behavioral therapy; repetitive transcranial magnetic stimulation

Treatment-resistant depression (TRD) is considered one of the major clinical challenges in the field of psychiatry. An estimated 44% of patients with major depressive disorder (MDD) do not respond to two consecutive antidepressant therapies, and 33% do not respond to up to four antidepressants. Over...