A prospective and open-label study for the efficacy and safety of telbivudine in pregnancy for the prevention of perinatal transmission of hepatitis B virus infection

• Published in: Journal of hepatology Vol. 55; no. 6; pp. 1215 - 1221
• Main Authors: Han, Guo-Rong, Cao, Min-Kai, Zhao, Wei, Jiang, Hong-Xiu, Wang, Cui-Min, Bai, Shu-Fen, Yue, Xin, Wang, Gen-Ju, Tang, Xun, Fang, Zhi-Xun
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier B.V 01.12.2011; Elsevier
• Subjects: Adult; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral agents; Antiviral Agents - adverse effects; Antiviral Agents - therapeutic use; Biological and medical sciences; Chronic hepatitis B; DNA, Viral - blood; Female; Gastroenterology and Hepatology; Gastroenterology. Liver. Pancreas. Abdomen; Hepatitis B Antibodies - administration & dosage; Hepatitis B e Antigens - blood; Hepatitis B Surface Antigens - blood; Hepatitis B Vaccines - administration & dosage; Hepatitis B virus; Hepatitis B, Chronic - complications; Hepatitis B, Chronic - drug therapy; Hepatitis B, Chronic - prevention & control; Hepatitis B, Chronic - transmission; Human viral diseases; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical - prevention & control; Infectious diseases; Male; Medical sciences; Nucleosides - adverse effects; Nucleosides - therapeutic use; Perinatal transmission; Pharmacology. Drug treatments; Pregnancy; Pregnancy Complications, Infectious - drug therapy; Pregnancy Complications, Infectious - virology; Prospective Studies; Pyrimidinones - adverse effects; Pyrimidinones - therapeutic use; Telbivudine; Thymidine - analogs & derivatives; Treatment Outcome; Viral diseases; Viral hepatitis; Young Adult; AST; HBeAg; ALT; HBsAg; HBV-M; Perinatal transmission; Chronic hepatitis B; HBcAg; HBIG; Hepatitis B virus; CHB; Telbivudine; HBV; PCR; hepatitis B surface antigen; markers of HBV; hepatitis B immune globulin; alanine aminotransferase; hepatitis B e antigen; aspartate aminotransferase; hepatitis B core antigen; polymerase chain reaction; RNA-directed DNA polymerase; Toxicity; Transmission; Orthohepadnavirus; Hepatic disease; Viral hepatitis B; Prevention; Hepadnaviridae; Gastroenterology; Nucleoside analog; Antiviral; DNA polymerase inhibitor; Enzyme; Transferases; Perinatal; Infection; Virus; Pregnancy; Nucleotidyltransferases; Viral disease; Digestive diseases

In the Asia–Pacific region, perinatal transmission of the hepatitis B virus (HBV) is the primary cause of chronic hepatitis B infection. Despite the use of HBIG and HBV vaccination, HBV perinatal transmission (PT) occurs in 10–30% of infants born to highly viremic mothers. We evaluated the efficacy...