Modulation of Tryptophan/Serotonin Pathway by Probiotic Supplementation in Human Immunodeficiency Virus–Positive Patients: Preliminary Results of a New Study Approach

Background: To date, no data are available regarding the effects of probiotics on the pathway of tryptophan/serotonin metabolism among human immunodeficiency virus (HIV) 1–infected individuals. Because a condition of dysbiosis might be responsible for the altered use of tryptophan described in this...

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Published inInternational journal of tryptophan research Vol. 10; p. 1178646917710668
Main Authors Corano Scheri, Giuseppe, Fard, Saeid Najafi, Schietroma, Ivan, Mastrangelo, Andrea, Pinacchio, Claudia, Giustini, Noemi, Serafino, Sara, De Girolamo, Gabriella, Cavallari, Eugenio Nelson, Statzu, Maura, Laghi, Luca, Vullo, Annamaria, Ceccarelli, Giancarlo, Vullo, Vincenzo, d’Ettorre, Gabriella
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 2017
Sage Publications Ltd. (UK)
Sage Publications Ltd
Subjects
Authorship
Deoxyribonucleic acid
Dietary supplements
DNA
Ethics
Feces
Health aspects
HIV
HIV patients
Human immunodeficiency virus
Hypotheses
Immune system
Infectious diseases
Inflammation
Metabolism
Metabolites
Original Research
Peer review
Polymerase chain reaction
Probiotics
Public health
Review boards
Serotonin
Studies
Tryptophan
Canada
United States > US
Probiotics
serotonin
IFN-γ
HIV
IDO-1
tryptophan
Online AccessGet full text
ISSN1178-6469
1178-6469
DOI10.1177/1178646917710668

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Abstract Background: To date, no data are available regarding the effects of probiotics on the pathway of tryptophan/serotonin metabolism among human immunodeficiency virus (HIV) 1–infected individuals. Because a condition of dysbiosis might be responsible for the altered use of tryptophan described in this population, the aim of this study was to investigate the link between probiotic supplementation and serotonin levels in combined antiretroviral therapy–treated patients and the subsistence of an interplay with inflammation. Methods: We conducted a pilot study that included 8 HIV-positive subjects. We collected blood and fecal samples before and after 6 months of probiotic supplementation, to measure the level of serotonin in serum and tryptophan in stool, the expression of CD38 and HLA-DR on peripheral CD4+ T lymphocytes (as immune activation markers), the expression of indoleamine 2,3-dioxygenase 1 messenger RNA (mRNA) and IFN-γ mRNA (as markers of tryptophan metabolism and systemic inflammation). Results: After probiotic supplementation, we observed a significant increase in concentration of serum serotonin (P = .008) and a decreased level of tryptophan in plasma. Moreover, a significant reduction in CD38 and HLA-DR expression on the surface of peripheral CD4+ T cells (P = .008) and a reduced expression of indoleamine 2,3-dioxygenase 1 mRNA on peripheral blood mononuclear cells (P = .04) were observed. Conclusions: Considering that this probiotic (Vivomixx® in EU; Visbiome® in USA) has an influence on tryptophan metabolism, larger studies on this topic are needed.
AbstractList Background:To date, no data are available regarding the effects of probiotics on the pathway of tryptophan/serotonin metabolism among human immunodeficiency virus (HIV) 1–infected individuals. Because a condition of dysbiosis might be responsible for the altered use of tryptophan described in this population, the aim of this study was to investigate the link between probiotic supplementation and serotonin levels in combined antiretroviral therapy–treated patients and the subsistence of an interplay with inflammation.Methods:We conducted a pilot study that included 8 HIV-positive subjects. We collected blood and fecal samples before and after 6 months of probiotic supplementation, to measure the level of serotonin in serum and tryptophan in stool, the expression of CD38 and HLA-DR on peripheral CD4+ T lymphocytes (as immune activation markers), the expression of indoleamine 2,3-dioxygenase 1 messenger RNA (mRNA) and IFN-γ mRNA (as markers of tryptophan metabolism and systemic inflammation).Results:After probiotic supplementation, we observed a significant increase in concentration of serum serotonin (P = .008) and a decreased level of tryptophan in plasma. Moreover, a significant reduction in CD38 and HLA-DR expression on the surface of peripheral CD4+ T cells (P = .008) and a reduced expression of indoleamine 2,3-dioxygenase 1 mRNA on peripheral blood mononuclear cells (P = .04) were observed.Conclusions:Considering that this probiotic (Vivomixx® in EU; Visbiome® in USA) has an influence on tryptophan metabolism, larger studies on this topic are needed.
To date, no data are available regarding the effects of probiotics on the pathway of tryptophan/serotonin metabolism among human immunodeficiency virus (HIV) 1-infected individuals. Because a condition of dysbiosis might be responsible for the altered use of tryptophan described in this population, the aim of this study was to investigate the link between probiotic supplementation and serotonin levels in combined antiretroviral therapy-treated patients and the subsistence of an interplay with inflammation. We conducted a pilot study that included 8 HIV-positive subjects. We collected blood and fecal samples before and after 6 months of probiotic supplementation, to measure the level of serotonin in serum and tryptophan in stool, the expression of CD38 and HLA-DR on peripheral CD4+ T lymphocytes (as immune activation markers), the expression of indoleamine 2,3-dioxygenase 1 messenger RNA (mRNA) and IFN-γ mRNA (as markers of tryptophan metabolism and systemic inflammation). After probiotic supplementation, we observed a significant increase in concentration of serum serotonin ( = .008) and a decreased level of tryptophan in plasma. Moreover, a significant reduction in CD38 and HLA-DR expression on the surface of peripheral CD4+ T cells ( = .008) and a reduced expression of indoleamine 2,3-dioxygenase 1 mRNA on peripheral blood mononuclear cells ( = .04) were observed. Considering that this probiotic (Vivomixx® in EU; Visbiome® in USA) has an influence on tryptophan metabolism, larger studies on this topic are needed.
Background: To date, no data are available regarding the effects of probiotics on the pathway of tryptophan/serotonin metabolism among human immunodeficiency virus (HIV) 1–infected individuals. Because a condition of dysbiosis might be responsible for the altered use of tryptophan described in this population, the aim of this study was to investigate the link between probiotic supplementation and serotonin levels in combined antiretroviral therapy–treated patients and the subsistence of an interplay with inflammation. Methods: We conducted a pilot study that included 8 HIV-positive subjects. We collected blood and fecal samples before and after 6 months of probiotic supplementation, to measure the level of serotonin in serum and tryptophan in stool, the expression of CD38 and HLA-DR on peripheral CD4+ T lymphocytes (as immune activation markers), the expression of indoleamine 2,3-dioxygenase 1 messenger RNA (mRNA) and IFN-γ mRNA (as markers of tryptophan metabolism and systemic inflammation). Results: After probiotic supplementation, we observed a significant increase in concentration of serum serotonin (P = .008) and a decreased level of tryptophan in plasma. Moreover, a significant reduction in CD38 and HLA-DR expression on the surface of peripheral CD4+ T cells (P = .008) and a reduced expression of indoleamine 2,3-dioxygenase 1 mRNA on peripheral blood mononuclear cells (P = .04) were observed. Conclusions: Considering that this probiotic (Vivomixx® in EU; Visbiome® in USA) has an influence on tryptophan metabolism, larger studies on this topic are needed.
To date, no data are available regarding the effects of probiotics on the pathway of tryptophan/serotonin metabolism among human immunodeficiency virus (HIV) 1-infected individuals. Because a condition of dysbiosis might be responsible for the altered use of tryptophan described in this population, the aim of this study was to investigate the link between probiotic supplementation and serotonin levels in combined antiretroviral therapy-treated patients and the subsistence of an interplay with inflammation.BACKGROUNDTo date, no data are available regarding the effects of probiotics on the pathway of tryptophan/serotonin metabolism among human immunodeficiency virus (HIV) 1-infected individuals. Because a condition of dysbiosis might be responsible for the altered use of tryptophan described in this population, the aim of this study was to investigate the link between probiotic supplementation and serotonin levels in combined antiretroviral therapy-treated patients and the subsistence of an interplay with inflammation.We conducted a pilot study that included 8 HIV-positive subjects. We collected blood and fecal samples before and after 6 months of probiotic supplementation, to measure the level of serotonin in serum and tryptophan in stool, the expression of CD38 and HLA-DR on peripheral CD4+ T lymphocytes (as immune activation markers), the expression of indoleamine 2,3-dioxygenase 1 messenger RNA (mRNA) and IFN-γ mRNA (as markers of tryptophan metabolism and systemic inflammation).METHODSWe conducted a pilot study that included 8 HIV-positive subjects. We collected blood and fecal samples before and after 6 months of probiotic supplementation, to measure the level of serotonin in serum and tryptophan in stool, the expression of CD38 and HLA-DR on peripheral CD4+ T lymphocytes (as immune activation markers), the expression of indoleamine 2,3-dioxygenase 1 messenger RNA (mRNA) and IFN-γ mRNA (as markers of tryptophan metabolism and systemic inflammation).After probiotic supplementation, we observed a significant increase in concentration of serum serotonin (P = .008) and a decreased level of tryptophan in plasma. Moreover, a significant reduction in CD38 and HLA-DR expression on the surface of peripheral CD4+ T cells (P = .008) and a reduced expression of indoleamine 2,3-dioxygenase 1 mRNA on peripheral blood mononuclear cells (P = .04) were observed.RESULTSAfter probiotic supplementation, we observed a significant increase in concentration of serum serotonin (P = .008) and a decreased level of tryptophan in plasma. Moreover, a significant reduction in CD38 and HLA-DR expression on the surface of peripheral CD4+ T cells (P = .008) and a reduced expression of indoleamine 2,3-dioxygenase 1 mRNA on peripheral blood mononuclear cells (P = .04) were observed.Considering that this probiotic (Vivomixx® in EU; Visbiome® in USA) has an influence on tryptophan metabolism, larger studies on this topic are needed.CONCLUSIONSConsidering that this probiotic (Vivomixx® in EU; Visbiome® in USA) has an influence on tryptophan metabolism, larger studies on this topic are needed.
Audience Academic
Author Vullo, Vincenzo
Laghi, Luca
Fard, Saeid Najafi
Statzu, Maura
Giustini, Noemi
Mastrangelo, Andrea
Serafino, Sara
Ceccarelli, Giancarlo
Corano Scheri, Giuseppe
Schietroma, Ivan
Vullo, Annamaria
De Girolamo, Gabriella
d’Ettorre, Gabriella
Cavallari, Eugenio Nelson
Pinacchio, Claudia
AuthorAffiliation 1 Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy
2 Laboratory of Virology, Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy
5 Department of Anatomical, Histological, Forensic and Orthopaedic Sciences,Sapienza University of Rome, Rome, Italy
4 Department of Agro-Food Science and Technology, University of Bologna, Bologna, Italy
3 Department of Public Health and Infectious Diseases, Azienda Policlinico Umberto I, Rome, Italy
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Cites_doi 10.1038/nm1511
10.1093/infdis/jiu238
10.1093/infdis/jiw258
10.1016/j.cll.2014.08.005
10.3389/fnins.2014.00012
10.1016/j.it.2006.02.008
10.1007/978-1-4684-5952-4_39
10.1371/journal.pone.0078146
10.1111/imr.12072
10.1002/0471142735.im0701s85
10.1038/nri1457
10.1038/ni.2947
10.1111/j.1541-0420.2007.00923.x
10.1186/s41043-016-0042-4
10.1189/jlb.72.6.1148
10.1093/infdis/jiu254
10.1084/jem.167.4.1341
10.4093/dmj.2015.39.4.291
10.1016/j.imbio.2015.10.007
10.1063/1.1716296
10.1096/fasebj.30.1_supplement.1259.3
10.4137/IJTR.S2129
10.1111/j.1541-0420.2005.00389.x
10.1155/2014/569819
10.1136/gutjnl-2016-312377.
10.1038/ki.2015.255
10.1128/JVI.02690-10
10.3748/wjg.v22.i29.6673
10.4049/jimmunol.1502470
10.1016/0165-2478(90)90178-S
10.1371/journal.pone.0130715
10.1128/AEM.70.1.167-173.2004
10.1182/blood-2008-07-144485
10.1039/C5FO01190F
10.1016/j.cell.2013.11.035
10.3389/fpsyt.2015.00097
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Keywords Probiotics
serotonin
IFN-γ
HIV
IDO-1
tryptophan
Language English
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References Jenabian, Patel, Kema 2013; 8
Scagnolari, Monteleone, Selvaggi 2016; 221
Datta, Satten 2008; 64
Schmitt, Liu, Bentebibel 2014; 15
Dotan, Rachmilewitz 2005; 21
Tenorio, Zheng, Bosch 2014; 210
Wood, Sawitzki 2006; 27
Sung, Kim, Hong, Suk 2016; 22
Gilbert, Krajmalnik-Brown, Porazinska, Weiss, Knight 2013; 155
Curti, Trabanelli, Salvestrini, Baccarani, Lemoli 2009; 113
Bolton, Pegu, Wang 2015; 90
Matsuki, Watanabe, Fujimoto 2004; 70
Hunt, Sinclair, Rodriguez 2014; 210
Koppe, Mafra, Fouque 2015; 88
Barbara, Scaioli, Barbaro 2016
Fuss, Kanof, Smith, Zola 2009
Lyle, Erickson, Walton 2016; 30
Mudd, Brenchley 2016; 214
Wirleitner, Reider, Ebner 2002; 72
Mancuso, Hernis, Agostini 2015; 10
Bipath, Levay, Viljoen 2016; 35
Xu, Wang, Veazey 2013; 254
Fuchs, Hausen, Reibnegger 1989; 2
Brown, Ozaki, Datta, Borden, Sondel, Malone 1991; 294
Salas, Chang 2014; 34
Le Barz, Anhê, Varin 2015; 39
Rosner, Glynn, Lee 2006; 62
Campbell, Charych, Lee, Möller 2014; 8
Manuzak, Hensley-McBain, Zevin 2016; 196
Chahroudi, Meeker, Lawson, Ratcliffe, Else, Silvestri 2011; 85
Richard, Dawes, Mathias, Acheson, Hill-Kapturczak, Dougherty 2009; 2
Meiboom, Gill 1958; 29
Gostner, Becker, Kurz, Fuchs 2015; 6
Brenchley, Price, Schacker 2006; 12
MacDonald, Spencer 1988; 167
Anzinger, Butterfield, Angelovich, Crowe, Palmer 2014; 2014
Fuchs, Jager, Popescu 1990; 26
Thushara, Gangadaran, Solati, Moghadasian 2016; 7
Mellor, Munn 2004; 4
Lyle S (bibr32-1178646917710668) 2016; 30
bibr34-1178646917710668
bibr26-1178646917710668
bibr33-1178646917710668
bibr13-1178646917710668
bibr8-1178646917710668
bibr20-1178646917710668
bibr39-1178646917710668
bibr4-1178646917710668
bibr11-1178646917710668
bibr35-1178646917710668
bibr18-1178646917710668
bibr19-1178646917710668
bibr9-1178646917710668
bibr14-1178646917710668
bibr1-1178646917710668
bibr27-1178646917710668
bibr5-1178646917710668
bibr10-1178646917710668
Wirleitner B (bibr17-1178646917710668) 2002; 72
bibr23-1178646917710668
bibr6-1178646917710668
bibr28-1178646917710668
bibr36-1178646917710668
bibr22-1178646917710668
bibr37-1178646917710668
bibr2-1178646917710668
bibr24-1178646917710668
Bolton DL (bibr7-1178646917710668) 2015; 90
bibr30-1178646917710668
bibr16-1178646917710668
bibr29-1178646917710668
bibr38-1178646917710668
bibr21-1178646917710668
Dotan I (bibr31-1178646917710668) 2005; 21
bibr12-1178646917710668
Fuchs D (bibr15-1178646917710668) 1989; 2
bibr3-1178646917710668
bibr25-1178646917710668
16527542 - Trends Immunol. 2006 Apr;27(4):183-7
24755434 - J Infect Dis. 2014 Oct 15;210(8):1228-38
26563749 - Immunobiology. 2016 Feb;221(2):282-90
25439273 - Clin Lab Med. 2014 Dec;34(4):733-45
24147117 - PLoS One. 2013 Oct 16;8(10):e78146
21450815 - J Virol. 2011 Jun;85(12):5757-63
27547010 - World J Gastroenterol. 2016 Aug 7;22(29):6673-82
24567701 - Front Neurosci. 2014 Feb 06;8:12
25025081 - J Immunol Res. 2014;2014:569819
1722946 - Adv Exp Med Biol. 1991;294:425-35
25064073 - Nat Immunol. 2014 Sep;15(9):856-65
15459668 - Nat Rev Immunol. 2004 Oct;4(10):762-74
24795473 - J Infect Dis. 2014 Oct 15;210(8):1248-59
24360269 - Cell. 2013 Dec 19;155(7):1446-8
12488496 - J Leukoc Biol. 2002 Dec;72(6):1148-53
20651948 - Int J Tryptophan Res. 2009 Mar 23;2:45-60
26581981 - J Virol. 2015 Nov 18;90(3):1321-32
26236243 - Front Psychiatry. 2015 Jul 14;6:97
14711639 - Appl Environ Microbiol. 2004 Jan;70(1):167-73
16542245 - Biometrics. 2006 Mar;62(1):185-92
26376131 - Kidney Int. 2015 Nov;88(5):958-66
26786971 - Food Funct. 2016 Feb;7(2):632-42
27618836 - Gut. 2017 Jul;66(7):1252-1261
17115046 - Nat Med. 2006 Dec;12(12):1365-71
17970820 - Biometrics. 2008 Jun;64(2):501-7
27625432 - J Infect Dis. 2016 Oct 1;214 Suppl 2:S58-66
19347849 - Curr Protoc Immunol. 2009 Apr;Chapter 7:Unit7.1
26826246 - J Immunol. 2016 Mar 1;196 (5):2401-9
23772612 - Immunol Rev. 2013 Jul;254(1):10-33
2965735 - J Exp Med. 1988 Apr 1;167(4):1341-9
2125976 - Immunol Lett. 1990 Oct;26(1):75-9
15930982 - Curr Opin Gastroenterol. 2005 Jul;21(4):426-30
26301190 - Diabetes Metab J. 2015 Aug;39(4):291-303
19023117 - Blood. 2009 Mar 12;113(11):2394-401
26887418 - J Health Popul Nutr. 2016 Feb 17;35:5
2495349 - J Acquir Immune Defic Syndr. 1989;2(2):158-62
26110930 - PLoS One. 2015 Jun 25;10(6):e0130715
References_xml – volume: 35
  start-page: 5
  year: 2016
  article-title: Tryptophan depletion in context of the inflammatory and general nutritional status of a low-income South African HIV-infected population
  publication-title: J Health Popul Nutr
– volume: 27
  start-page: 183
  year: 2006
  end-page: 187
  article-title: Interferon gamma: a crucial role in the function of induced regulatory T cells in vivo
  publication-title: Trends Immunol
– volume: 2
  start-page: 158
  year: 1989
  end-page: 162
  article-title: Interferon-gamma concentrations are increased in sera from individuals infected with human immunodeficiency virus type 1
  publication-title: J Acquir Immune Defic Syndr
– volume: 10
  start-page: e0130715
  year: 2015
  article-title: Indoleamine 2,3 dioxygenase (IDO) expression and activity in relapsing-remitting multiple sclerosis
  publication-title: PLoS ONE
– volume: 167
  start-page: 1341
  year: 1988
  end-page: 1349
  article-title: Evidence that activated mucosal T cells play a role in the pathogenesis of enteropathy in human small intestine
  publication-title: J Exp Med
– volume: 22
  start-page: 6673
  year: 2016
  end-page: 6682
  article-title: Microbiota-based treatments in alcoholic liver disease
  publication-title: World J Gastroenterol
– volume: 4
  start-page: 762
  year: 2004
  end-page: 774
  article-title: IDO expression by dendritic cells: tolerance and tryptophan catabolism
  publication-title: Nat Rev Immunol
– volume: 2
  start-page: 45
  year: 2009
  end-page: 60
  article-title: L-Tryptophan: basic metabolic functions, behavioral research and therapeutic indications
  publication-title: Int J Tryptophan Res
– volume: 85
  start-page: 5757
  year: 2011
  end-page: 5763
  article-title: Mother-to-infant transmission of simian immunodeficiency virus is rare in sooty mangabeys and is associated with low viremia
  publication-title: J Virol
– volume: 2014
  start-page: 569819
  year: 2014
  article-title: Monocytes as regulators of inflammation and HIV-related comorbidities during cART
  publication-title: J Immunol Res
– volume: 254
  start-page: 10
  year: 2013
  end-page: 33
  article-title: Mucosal immunology of HIV infection
  publication-title: Immunol Rev
– volume: 210
  start-page: 1228
  year: 2014
  end-page: 1238
  article-title: Gut epithelial barrier dysfunction and innate immune activation predict mortality in treated HIV infection
  publication-title: J Infect Dis
– volume: 210
  start-page: 1248
  year: 2014
  end-page: 1259
  article-title: Soluble markers of inflammation and coagulation but not T-cell activation predict non-AIDS-defining morbid events during suppressive antiretroviral treatment
  publication-title: J Infect Dis
– year: 2009
  article-title: Isolation of whole mononuclear cells from peripheral blood and cord blood
  publication-title: Curr Protoc Immunol
– volume: 62
  start-page: 185
  year: 2006
  end-page: 192
  article-title: The Wilcoxon signed rank test for paired comparisons of clustered data
  publication-title: Biometrics
– volume: 214
  start-page: S58
  year: 2016
  end-page: S66
  article-title: Gut mucosal barrier dysfunction, microbial dysbiosis, and their role in HIV-1 disease progression
  publication-title: J Infect Dis
– volume: 70
  start-page: 167
  year: 2004
  end-page: 173
  article-title: Quantitative PCR with 16S rRNA-gene-targeted species-specific primers for analysis of human intestinal bifidobacteria
  publication-title: Appl Environ Microbiol
– volume: 30
  year: 2016
  article-title: Effects of probiotic bacteria on cytokine expression in cultured intestinal epithelial cells
  publication-title: FASEB J
– volume: 26
  start-page: 75
  year: 1990
  end-page: 79
  article-title: Immune activation markers to predict AIDS and survival in HIV-1 seropositives
  publication-title: Immunol Lett
– volume: 72
  start-page: 1148
  year: 2002
  end-page: 1153
  article-title: Monocyte-derived dendritic cells release neopterin
  publication-title: J Leukoc Biol
– volume: 221
  start-page: 282
  year: 2016
  end-page: 290
  article-title: ISG15 expression correlates with HIV-1 viral load and with factors regulating T cell response
  publication-title: Immunobiology
– volume: 88
  start-page: 958
  year: 2015
  end-page: 966
  article-title: Probiotics and chronic kidney disease
  publication-title: Kidney Int
– volume: 8
  start-page: e78146
  year: 2013
  article-title: Distinct tryptophan catabolism and Th17/Treg balance in HIV progressors and elite controllers
  publication-title: PLoS ONE
– volume: 294
  start-page: 425
  year: 1991
  end-page: 435
  article-title: Implications of interferon-induced tryptophan catabolism in cancer, auto-immune diseases and AIDS
  publication-title: Adv Exp Med Biol
– volume: 12
  start-page: 1365
  year: 2006
  end-page: 1371
  article-title: Microbial translocation is a cause of systemic immune activation in chronic HIV infection
  publication-title: Nat Med
– volume: 64
  start-page: 501
  year: 2008
  end-page: 507
  article-title: A signed-rank test for clustered data
  publication-title: Biometrics
– volume: 113
  start-page: 2394
  year: 2009
  end-page: 2401
  article-title: The role of indoleamine 2,3-dioxygenase in the induction of immune tolerance: focus on hematology
  publication-title: Blood
– volume: 8
  start-page: 12
  year: 2014
  article-title: Kynurenines in CNS disease: regulation by inflammatory cytokines
  publication-title: Front Neurosci
– volume: 39
  start-page: 291
  year: 2015
  end-page: 303
  article-title: Probiotics as complementary treatment for metabolic disorders
  publication-title: Diabetes Metab J
– volume: 6
  year: 2015
  article-title: Disturbed amino acid metabolism in HIV: association with neuropsychiatric symptoms
  publication-title: Front Psychiatry
– volume: 90
  start-page: 1321
  year: 2015
  end-page: 1332
  article-title: Human immunodeficiency virus type 1 monoclonal antibodies suppress acute simian-human immunodeficiency virus viremia and limit seeding of cell-associated viral reservoirs
  publication-title: J Immunol Res
– volume: 15
  start-page: 856
  year: 2014
  end-page: 865
  article-title: The cytokine TGF-β co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells
  publication-title: Nat Immunol
– volume: 34
  start-page: 733
  year: 2014
  end-page: 745
  article-title: Microbiome in human immunodeficiency virus infection
  publication-title: Clin Lab Med
– volume: 155
  start-page: 1446
  year: 2013
  end-page: 1448
  article-title: Toward effective probiotics for autism and other neurodevelopmental disorders
  publication-title: Cell
– volume: 29
  start-page: 688
  year: 1958
  end-page: 691
  article-title: Modified spin-echo method for measuring nuclear relaxation times
  publication-title: Rev Sci Instrum
– volume: 7
  start-page: 632
  year: 2016
  end-page: 642
  article-title: Cardiovascular benefits of probiotics: a review of experimental and clinical studies
  publication-title: Food Funct
– volume: 21
  start-page: 426
  year: 2005
  end-page: 430
  article-title: Probiotics in inflammatory bowel disease: possible mechanisms of action
  publication-title: Curr Opin Gastroenterol
– volume: 196
  start-page: 2401
  year: 2016
  end-page: 2409
  article-title: Enhancement of microbiota in healthy macaques results in beneficial modulation of mucosal and systemic immune function
  publication-title: J Immunol
– year: 2016
  article-title: Gut microbiota, metabolome and immune signatures in patients with uncomplicated diverticular disease
  publication-title: Gut
– ident: bibr34-1178646917710668
  doi: 10.1038/nm1511
– ident: bibr6-1178646917710668
  doi: 10.1093/infdis/jiu238
– ident: bibr9-1178646917710668
  doi: 10.1093/infdis/jiw258
– ident: bibr4-1178646917710668
  doi: 10.1016/j.cll.2014.08.005
– ident: bibr39-1178646917710668
  doi: 10.3389/fnins.2014.00012
– ident: bibr10-1178646917710668
  doi: 10.1016/j.it.2006.02.008
– ident: bibr12-1178646917710668
  doi: 10.1007/978-1-4684-5952-4_39
– ident: bibr36-1178646917710668
  doi: 10.1371/journal.pone.0078146
– ident: bibr3-1178646917710668
  doi: 10.1111/imr.12072
– ident: bibr24-1178646917710668
  doi: 10.1002/0471142735.im0701s85
– ident: bibr11-1178646917710668
  doi: 10.1038/nri1457
– ident: bibr35-1178646917710668
  doi: 10.1038/ni.2947
– ident: bibr29-1178646917710668
  doi: 10.1111/j.1541-0420.2007.00923.x
– volume: 2
  start-page: 158
  year: 1989
  ident: bibr15-1178646917710668
  publication-title: J Acquir Immune Defic Syndr
– ident: bibr13-1178646917710668
  doi: 10.1186/s41043-016-0042-4
– volume: 72
  start-page: 1148
  year: 2002
  ident: bibr17-1178646917710668
  publication-title: J Leukoc Biol
  doi: 10.1189/jlb.72.6.1148
– ident: bibr5-1178646917710668
  doi: 10.1093/infdis/jiu254
– ident: bibr1-1178646917710668
  doi: 10.1084/jem.167.4.1341
– volume: 21
  start-page: 426
  year: 2005
  ident: bibr31-1178646917710668
  publication-title: Curr Opin Gastroenterol
– volume: 90
  start-page: 1321
  year: 2015
  ident: bibr7-1178646917710668
  publication-title: J Immunol Res
– ident: bibr22-1178646917710668
  doi: 10.4093/dmj.2015.39.4.291
– ident: bibr26-1178646917710668
  doi: 10.1016/j.imbio.2015.10.007
– ident: bibr27-1178646917710668
  doi: 10.1063/1.1716296
– volume: 30
  year: 2016
  ident: bibr32-1178646917710668
  publication-title: FASEB J
  doi: 10.1096/fasebj.30.1_supplement.1259.3
– ident: bibr14-1178646917710668
  doi: 10.4137/IJTR.S2129
– ident: bibr30-1178646917710668
  doi: 10.1111/j.1541-0420.2005.00389.x
– ident: bibr8-1178646917710668
  doi: 10.1155/2014/569819
– ident: bibr28-1178646917710668
  doi: 10.1136/gutjnl-2016-312377.
– ident: bibr20-1178646917710668
  doi: 10.1038/ki.2015.255
– ident: bibr2-1178646917710668
  doi: 10.1128/JVI.02690-10
– ident: bibr19-1178646917710668
  doi: 10.3748/wjg.v22.i29.6673
– ident: bibr33-1178646917710668
  doi: 10.4049/jimmunol.1502470
– ident: bibr16-1178646917710668
  doi: 10.1016/0165-2478(90)90178-S
– ident: bibr37-1178646917710668
  doi: 10.1371/journal.pone.0130715
– ident: bibr25-1178646917710668
  doi: 10.1128/AEM.70.1.167-173.2004
– ident: bibr38-1178646917710668
  doi: 10.1182/blood-2008-07-144485
– ident: bibr21-1178646917710668
  doi: 10.1039/C5FO01190F
– ident: bibr23-1178646917710668
  doi: 10.1016/j.cell.2013.11.035
– ident: bibr18-1178646917710668
  doi: 10.3389/fpsyt.2015.00097
– reference: 20651948 - Int J Tryptophan Res. 2009 Mar 23;2:45-60
– reference: 23772612 - Immunol Rev. 2013 Jul;254(1):10-33
– reference: 27618836 - Gut. 2017 Jul;66(7):1252-1261
– reference: 2965735 - J Exp Med. 1988 Apr 1;167(4):1341-9
– reference: 24360269 - Cell. 2013 Dec 19;155(7):1446-8
– reference: 26826246 - J Immunol. 2016 Mar 1;196 (5):2401-9
– reference: 26887418 - J Health Popul Nutr. 2016 Feb 17;35:5
– reference: 16527542 - Trends Immunol. 2006 Apr;27(4):183-7
– reference: 25064073 - Nat Immunol. 2014 Sep;15(9):856-65
– reference: 19347849 - Curr Protoc Immunol. 2009 Apr;Chapter 7:Unit7.1
– reference: 24567701 - Front Neurosci. 2014 Feb 06;8:12
– reference: 15930982 - Curr Opin Gastroenterol. 2005 Jul;21(4):426-30
– reference: 15459668 - Nat Rev Immunol. 2004 Oct;4(10):762-74
– reference: 1722946 - Adv Exp Med Biol. 1991;294:425-35
– reference: 26563749 - Immunobiology. 2016 Feb;221(2):282-90
– reference: 17115046 - Nat Med. 2006 Dec;12(12):1365-71
– reference: 2495349 - J Acquir Immune Defic Syndr. 1989;2(2):158-62
– reference: 26786971 - Food Funct. 2016 Feb;7(2):632-42
– reference: 16542245 - Biometrics. 2006 Mar;62(1):185-92
– reference: 24755434 - J Infect Dis. 2014 Oct 15;210(8):1228-38
– reference: 24147117 - PLoS One. 2013 Oct 16;8(10):e78146
– reference: 2125976 - Immunol Lett. 1990 Oct;26(1):75-9
– reference: 25025081 - J Immunol Res. 2014;2014:569819
– reference: 24795473 - J Infect Dis. 2014 Oct 15;210(8):1248-59
– reference: 27547010 - World J Gastroenterol. 2016 Aug 7;22(29):6673-82
– reference: 17970820 - Biometrics. 2008 Jun;64(2):501-7
– reference: 21450815 - J Virol. 2011 Jun;85(12):5757-63
– reference: 12488496 - J Leukoc Biol. 2002 Dec;72(6):1148-53
– reference: 26376131 - Kidney Int. 2015 Nov;88(5):958-66
– reference: 26301190 - Diabetes Metab J. 2015 Aug;39(4):291-303
– reference: 19023117 - Blood. 2009 Mar 12;113(11):2394-401
– reference: 26110930 - PLoS One. 2015 Jun 25;10(6):e0130715
– reference: 14711639 - Appl Environ Microbiol. 2004 Jan;70(1):167-73
– reference: 26236243 - Front Psychiatry. 2015 Jul 14;6:97
– reference: 27625432 - J Infect Dis. 2016 Oct 1;214 Suppl 2:S58-66
– reference: 25439273 - Clin Lab Med. 2014 Dec;34(4):733-45
– reference: 26581981 - J Virol. 2015 Nov 18;90(3):1321-32
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Snippet Background: To date, no data are available regarding the effects of probiotics on the pathway of tryptophan/serotonin metabolism among human immunodeficiency...
To date, no data are available regarding the effects of probiotics on the pathway of tryptophan/serotonin metabolism among human immunodeficiency virus (HIV)...
Background:To date, no data are available regarding the effects of probiotics on the pathway of tryptophan/serotonin metabolism among human immunodeficiency...
Background: To date, no data are available regarding the effects of probiotics on the pathway of tryptophan/serotonin metabolism among human immunodeficiency...
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Publisher
StartPage 1178646917710668
SubjectTerms Authorship
Deoxyribonucleic acid
Dietary supplements
DNA
Ethics
Feces
Health aspects
HIV
HIV patients
Human immunodeficiency virus
Hypotheses
Immune system
Infectious diseases
Inflammation
Metabolism
Metabolites
Original Research
Peer review
Polymerase chain reaction
Probiotics
Public health
Review boards
Serotonin
Studies
Tryptophan
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Title Modulation of Tryptophan/Serotonin Pathway by Probiotic Supplementation in Human Immunodeficiency Virus–Positive Patients: Preliminary Results of a New Study Approach
URI https://journals.sagepub.com/doi/full/10.1177/1178646917710668
https://www.ncbi.nlm.nih.gov/pubmed/28607543
https://www.proquest.com/docview/2081577805
https://www.proquest.com/docview/2422750825
https://www.proquest.com/docview/1909224358
https://pubmed.ncbi.nlm.nih.gov/PMC5457170
Volume 10
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