Optimization and Reliability of Multiple Postlabeling Delay Pseudo-Continuous Arterial Spin Labeling during Rest and Stimulus-Induced Functional Task Activation

• Published in: Journal of cerebral blood flow and metabolism Vol. 34; no. 12; pp. 1919 - 1927
• Main Authors: Mezue, Melvin, Segerdahl, Andrew R, Okell, Thomas W, Chappell, Michael A, Kelly, Michael E, Tracey, Irene
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.12.2014; Sage Publications Ltd; Nature Publishing Group
• Subjects: Adult; Cerebral Arteries - physiology; Cerebrovascular Circulation - physiology; Female; Gray Matter - physiology; Humans; Magnetic Resonance Imaging - methods; Magnetic Resonance Imaging - standards; Male; Models, Cardiovascular; Original; Perfusion Imaging - methods; Perfusion Imaging - standards; Photic Stimulation - methods; Psychomotor Performance - physiology; Reproducibility of Results; Rest - physiology; Spin Labels; brain imaging; physiology; ASL; FMRI; cerebral blood flow measurement; kinetic modeling

Arterial spin labeling (ASL) sequences that incorporate multiple postlabeling delay (PLD) times allow estimation of when arterial blood signal arrives within a region of interest. Sequences that account for such variability may improve the reliability of ASL and therefore make the technique well sui...