Infection with colonization factor antigen I-expressing enterotoxigenic Escherichia coli boosts antibody responses against heterologous colonization factors in primed subjects
Enterotoxigenic Escherichia coli (ETEC) adhere to the intestinal mucosa by a number of fimbrial colonization factors (CFs) that have been claimed to induce only type-specific immunity. However, adult Bangladeshi patients infected with CFA/I-expressing bacteria, developed significant plasma IgA antib...
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| Published in | Epidemiology and infection Vol. 119; no. 3; pp. 391 - 393 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Cambridge
Cambridge University Press
01.12.1997
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0950-2688 1469-4409 |
| DOI | 10.1017/S0950268897008200 |
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| Abstract | Enterotoxigenic Escherichia coli (ETEC) adhere to
the intestinal mucosa by a number of
fimbrial colonization factors (CFs) that have been claimed to induce only
type-specific
immunity. However, adult Bangladeshi patients infected with CFA/I-expressing
bacteria,
developed significant plasma IgA antibody responses, as determined by enzyme-linked
immunosorbent assay, not only against the homologous fimbriae
but also against several
heterologous CFs, i.e. CS1, CS2, CS4 and PCFO166 fimbriae. In contrast,
North American
volunteers, who had probably not been infected by ETEC previously,
responded with serum
IgA against CFA/I fimbriae but not against any other CFs after
symptomatic infection with
CFA/I-expressing ETEC. Thus, infection with CFA/I-expressing
bacteria may boost immune
responses against CFs with a related amino acid sequence in
previously primed subjects. |
|---|---|
| AbstractList | Enterotoxigenic Escherichia coli (ETEC) adhere to the intestinal mucosa by a number of fimbrial colonization factors (CFs) that have been claimed to induce only type-specific immunity. However, adult Bangladeshi patients infected with CFA/I-expressing bacteria, developed significant plasma IgA antibody responses, as determined by enzyme-linked immunosorbent assay, not only against the homologous fimbriae but also against several heterologous CFs, i.e. CS1, CS2, CS4 and PCFO166 fimbriae. In contrast, North American volunteers, who had probably not been infected by ETEC previously, responded with serum IgA against CFA/I fimbriae but not against any other CFs after symptomatic infection with CFA/I-expressing ETEC. Thus, infection with CFA/I-expressing bacteria may boost immune responses against CFs with a related amino acid sequence in previously primed subjects.Enterotoxigenic Escherichia coli (ETEC) adhere to the intestinal mucosa by a number of fimbrial colonization factors (CFs) that have been claimed to induce only type-specific immunity. However, adult Bangladeshi patients infected with CFA/I-expressing bacteria, developed significant plasma IgA antibody responses, as determined by enzyme-linked immunosorbent assay, not only against the homologous fimbriae but also against several heterologous CFs, i.e. CS1, CS2, CS4 and PCFO166 fimbriae. In contrast, North American volunteers, who had probably not been infected by ETEC previously, responded with serum IgA against CFA/I fimbriae but not against any other CFs after symptomatic infection with CFA/I-expressing ETEC. Thus, infection with CFA/I-expressing bacteria may boost immune responses against CFs with a related amino acid sequence in previously primed subjects. Enterotoxigenic Escherichia coli (ETEC) adhere to the intestinal mucosa by a number of fimbrial colonization factors (CFs) that have been claimed to induce only type-specific immunity. However, adult Bangladeshi patients infected with CFA/I-expressing bacteria, developed significant plasma IgA antibody responses, as determined by enzyme-linked immunosorbent assay, not only against the homologous fimbriae but also against several heterologous CFs, i.e. CS1, CS2, CS4 and PCFO166 fimbriae. In contrast, North American volunteers, who had probably not been infected by ETEC previously, responded with serum IgA against CFA/I fimbriae but not against any other CFs after symptomatic infection with CFA/I-expressing ETEC. Thus, infection with CFA/I-expressing bacteria may boost immune responses against CFs with a related amino acid sequence in previously primed subjects. Enterotoxigenic Escherichia coli (ETEC) adhere to the intestinal mucosa by a number of fimbrial colonization factors (CFs) that have been claimed to induce only type-specific immunity. However, adult Bangladeshi patients infected with CFA/I-expressing bacteria, developed significant plasma IgA antibody responses, as determined by enzyme-linked immunosorbent assay, not only against the homologous fimbriae but also against several heterologous CFs, i.e. CS1, CS2, CS4 and PCFO166 fimbriae. In contrast, North American volunteers, who had probably not been infected by ETEC previously, responded with serum IgA against CFA/I fimbriae but not against any other CFs after symptomatic infection with CFA/I-expressing ETEC. Thus, infection with CFA/I-expressing bacteria may boost immune responses against CFs with a related amino acid sequence in previously primed subjects. Enterotoxigenic Escherichia coli (ETEC) adhere to the intestinal mucosa by a number of fimbrial colonization factors (CFs) that have been claimed to induce only type-specific immunity. However, adult Bangladeshi patients infected with CFA/I-expressing bacteria, developed significant plasma IgA antibody responses, as determined by enzyme-linked immunosorbent assay, not only against the homologous fimbriae but also against several heterologous CFs, i.e. CS1, CS2, CS4 and PCF0166 fimbriae. In contrast, North American volunteers, who had probably not been infected by ETEC previously, responded with serum IgA against CFA/I fimbriae but not against any other CFs after symptomatic infection with CFA/I-expressing ETEC. Thus, infection with CFA/I-expressing bacteria may boost immune responses against CFs with a related amino acid sequence in previously primed subjects. Enterotoxigenic Escherichia coli (ETEC) adhere to the intestinal mucosa by a number of fimbrial colonization factors (CFs) that have been claimed to induce only type-specific immunity. However, adult Bangladeshi patients infected with CFA/I-expressing bacteria, developed significant plasma IgA antibody responses, as determined by enzyme-linked immunosorbent assay, not only against the homologous fimbriae but also against several heterologous CFs, i.e. CS1, CS2, CS4 and PCFO166 fimbriae. In contrast, North American volunteers, who had probably not been infected by ETEC previously, responded with serum IgA against CFA/I fimbriae but not against any other CFs after symptomatic infection with CFA/I-expressing ETEC. Thus, infection with CFA/I-expressing bacteria may boost immune responses against CFs with a related amino acid sequence in previously primed subjects. |
| Author | WIKLUND, G. WENNERÅS, C. QADRI, F. RUDIN, A. |
| AuthorAffiliation | Department of Medical Microbiology and Immunology, Göteborg University, Sweden |
| AuthorAffiliation_xml | – name: Department of Medical Microbiology and Immunology, Göteborg University, Sweden |
| Author_xml | – sequence: 1 givenname: A. surname: RUDIN fullname: RUDIN, A. organization: Department of Medical Microbiology and Immunology, Göteborg University, Guldhedsgatan 10A, S-413 46 Göteborg, Sweden – sequence: 2 givenname: G. surname: WIKLUND fullname: WIKLUND, G. organization: Department of Medical Microbiology and Immunology, Göteborg University, Guldhedsgatan 10A, S-413 46 Göteborg, Sweden – sequence: 3 givenname: C. surname: WENNERÅS fullname: WENNERÅS, C. organization: Department of Medical Microbiology and Immunology, Göteborg University, Guldhedsgatan 10A, S-413 46 Göteborg, Sweden – sequence: 4 givenname: F. surname: QADRI fullname: QADRI, F. organization: International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh |
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| Snippet | Enterotoxigenic Escherichia coli (ETEC) adhere to
the intestinal mucosa by a number of
fimbrial colonization factors (CFs) that have been claimed to induce... Enterotoxigenic Escherichia coli (ETEC) adhere to the intestinal mucosa by a number of fimbrial colonization factors (CFs) that have been claimed to induce... Enterotoxigenic Escherichia coli (ETEC) adhere to the intestinal mucosa by a number of fimbrial colonization factors (CFs) that have been claimed to induce... |
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| SubjectTerms | Adult Antibodies Antibodies, Bacterial - immunology Antigens Bacteria Bacterial diseases Bacterial diseases of the digestive system and abdomen Bacterial Proteins - immunology Bangladesh Biological and medical sciences Diarrhea Enzyme linked immunosorbent assay Escherichia coli Escherichia coli Infections - immunology Fimbriae Fimbriae Proteins Human bacterial diseases Humans Immunity Immunology Infections Infectious diseases Medical sciences United States |
| Title | Infection with colonization factor antigen I-expressing enterotoxigenic Escherichia coli boosts antibody responses against heterologous colonization factors in primed subjects |
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