Antidepressive and cardioprotective effects of Kai-xin-san via the regulation of HPA axis dysfunction and lipid metabolism in a rat model of depressive-cardiac disease

• Published in: Brain research bulletin Vol. 219; p. 111126
• Main Authors: Yang, Wenshan, Wang, Yuanbo, Li, Xia, Jing, Rui, Mu, Lihua, Hu, Yuan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2024; Elsevier
• Subjects: Animals; Antidepressive Agents - pharmacology; Antidepressive Agents - therapeutic use; Cardiotonic Agents - pharmacology; Corticosterone - blood; Depression - drug therapy; Depression - metabolism; Depressive Disorder - drug therapy; Depressive Disorder - metabolism; depressive-cardiac disease; Disease Models, Animal; Drugs, Chinese Herbal - pharmacology; Drugs, Chinese Herbal - therapeutic use; Heart Diseases - metabolism; HPA axis; Hypothalamo-Hypophyseal System - drug effects; Hypothalamo-Hypophyseal System - metabolism; KXS; lipid metabolism; Lipid Metabolism - drug effects; Male; Myocardial Ischemia - complications; Myocardial Ischemia - metabolism; Pituitary-Adrenal System - drug effects; Pituitary-Adrenal System - metabolism; Rats; Rats, Sprague-Dawley; Stress, Psychological - drug therapy; Stress, Psychological - metabolism; FFA; CRS; CUMS; KXS; lipid metabolism; ACTH; HPA axis; HDL; CREB; PI3K; LDL; SPT; ApoA1; ApoC3; NLRP3; OFT; ApoB; ISO; BDNF; FST; depressive-cardiac disease; LAD; TC; CVD; CORT; TrkB; TG; CRH; HPA; ERK; TCM

Depressive-cardiac disease is a comorbid state in which both cardiovascular diseases and mental disorders are present. Patients with depression are more likely to develop cardiovascular disease, which increases the risk of cardiovascular events, such as acute coronary syndrome. Cardiovascular diseas...