Antidepressive and cardioprotective effects of Kai-xin-san via the regulation of HPA axis dysfunction and lipid metabolism in a rat model of depressive-cardiac disease - Yang, Wenshan; Wang, Yuanbo; Li, Xia; Jing, Rui; Mu, Lihua; Hu, Yuan (Brain research bulletin, 2024)
Keywords: Animals; Antidepressive Agents - pharmacology; Antidepressive Agents - therapeutic use; Cardiotonic Agents - pharmacology; Corticosterone - blood; Depression - drug therapy; Depression - metabolism; Depressive Disorder - drug therapy; Depressive Disorder - metabolism; depressive-cardiac disease; Disease Models, Animal; Drugs, Chinese Herbal - pharmacology; Drugs, Chinese Herbal - therapeutic use; Heart Diseases - metabolism; HPA axis; Hypothalamo-Hypophyseal System - drug effects; Hypothalamo-Hypophyseal System - metabolism; KXS; lipid metabolism; Lipid Metabolism - drug effects; Male; Myocardial Ischemia - complications; Myocardial Ischemia - metabolism; Pituitary-Adrenal System - drug effects; Pituitary-Adrenal System - metabolism; Rats; Rats, Sprague-Dawley; Stress, Psychological - drug therapy; Stress, Psychological - metabolism; FFA; CRS; CUMS; KXS; lipid metabolism; ACTH; HPA axis; HDL; CREB; PI3K; LDL; SPT; ApoA1; ApoC3; NLRP3; OFT; ApoB; ISO; BDNF; FST; depressive-cardiac disease; LAD; TC; CVD; CORT; TrkB; TG; CRH; HPA; ERK; TCM