Distinct Shift in Beta-Cell Glutaredoxin 5 Expression Is Mediated by Hypoxia and Lipotoxicity Both In Vivo and In Vitro

• Published in: Frontiers in Endocrinology Vol. 9; p. 84
• Main Authors: Petry, Sebastian Friedrich, Sun, Lia Mingzhe, Knapp, Anna, Reinl, Sabrina, Linn, Thomas
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media SA 12.03.2018; Frontiers Media S.A
• Subjects: db mouse; diabetes mellitus type 2; Diseases of the endocrine glands. Clinical endocrinology; Endocrinology; glutaredoxin; islet remodeling; MIN6; RC648-665; rodent diabesity; MIN6; islet remodeling; hypoxia; db mouse; lipotoxicity; diabetes mellitus type 2; glutaredoxin; rodent diabesity

Histomorphological and functional alterations in pancreatic islet composition directly correlate with hyperglycemia severity. Progressive deterioration of metabolic control in subjects suffering from type 2 diabetes is predominantly caused by impaired beta-cell functionality. The glutaredoxin system...