Immunoinformatics Study: Multi-Epitope Based Vaccine Design from SARS-CoV-2 Spike Glycoprotein

• Published in: Vaccines (Basel) Vol. 11; no. 2; p. 399
• Main Authors: Umitaibatin, Ramadhita, Harisna, Azza Hanif, Jauhar, Muhammad Miftah, Syaifie, Putri Hawa, Arda, Adzani Gaisani, Nugroho, Dwi Wahyu, Ramadhan, Donny, Mardliyati, Etik, Shalannanda, Wervyan, Anshori, Isa
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.02.2023; MDPI
• Subjects: Amino acids; Antibodies; Antigenic determinants; antigenic epitope; Antigens; Binding sites; CD4 antigen; CD8 antigen; Coronaviruses; COVID-19; COVID-19 vaccines; Cytotoxicity; Design; Dynamic stability; epitope prediction; Epitopes; Glycoproteins; Health aspects; LR-4; Lymphocytes; Lymphocytes B; Lymphocytes T; Molecular docking; Molecular dynamics; Mutation; Phylogenetics; Population; Proteins; Severe acute respiratory syndrome coronavirus 2; Side effects; Simulation; Spike glycoprotein; Spike protein; TLR-3; Vaccines; Vectors (Biology); Viral diseases; Viral infections; γ-Interferon; Indonesia; epitope prediction; antigenic epitope; TLR-3; spike glycoprotein; LR-4

The coronavirus disease 2019 outbreak has become a huge challenge in the human sector for the past two years. The coronavirus is capable of mutating at a higher rate than other viruses. Thus, an approach for creating an effective vaccine is still needed to induce antibodies against multiple variants...