Patterns of cytokine secretion in murine leishmaniasis: correlation with disease progression or resolution
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| Published in | Infection and Immunity Vol. 58; no. 12; pp. 3863 - 3870 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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Washington, DC
American Society for Microbiology
01.12.1990
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| AbstractList | Susceptibility or resistance to infection with Leishmania major correlates with the ability of mice to produce characteristic panels of lymphokines in response to the parasite. To investigate the role of antigen-presenting cells in this phenomenon, we developed a model system which used congenic (H-2 super(d)) susceptible and resistant mice. L. major)-specific T cells were isolated from infected BALB/c and B10.D2 mice, and the cells were restimulated in vitro on syngenetic or congenic antigen-presenting cells. BALB/c L. major -reactive T cells restimulated with either antigen-presenting cell produced high levels of interleukin-4 and low levels of gamma interferon. In contrast, T cells from B10.D2 mice produced gamma interferon. Radiation-induced chimeras reconstituted with BALB/c bone marrow also produced more interleukin-4 in response to L. major than did chimeras reconstituted with B10.D2 bone marrow. Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue IAI About IAI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy Connect to IAI IAI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0019-9567 Online ISSN: 1098-5522 Copyright © 2014 by the American Society for Microbiology. For an alternate route to IAI .asm.org, visit: IAI Susceptibility or resistance to infection with Leishmania major correlates with the ability of mice to produce characteristic panels of lymphokines in response to the parasite. To investigate the role of antigen-presenting cells in this phenomenon, we developed a model system which used congenic (H-2d) susceptible and resistant mice. L. major-specific T cells were isolated from infected BALB/c and B10.D2 mice, and the cells were restimulated in vitro on syngenic or congenic antigen-presenting cells. BALB/c L. major-reactive T cells restimulated with either antigen-presenting cell produced high levels of interleukin-4 and low levels of gamma interferon. In contrast, T cells from B10.D2 mice produced gamma interferon. Radiation-induced chimeras reconstituted with BALB/c bone marrow also produced more interleukin-4 in response to L. major than did chimeras reconstituted with B10.D2 bone marrow. To test whether this pattern of cytokine secretion was unique to infection with L. major, we infected the mice with a second intracellular pathogen, Mycobacterium bovis BCG. Mycobacterium-specific T cells from both BALB/c and B10.D2 mice produced interleukin-2 and no interleukin-4. Finally, when BALB/c mice were vaccinated with avirulent L. major, the induced resistance correlated with reduced production of interleukin-4 but no increase in gamma interferon production. Instead, T cells from the vaccinated mice produced high levels of tumor necrosis factor. This suggests that tumor necrosis factor, in addition to gamma interferon, may be involved in resistance to L. major and that interleukin-4 may inhibit the leishmanicidal activity of tumor necrosis factor and/or gamma interferon. |
| Author | A K Abbas W H Boom R G Titus L Liebster |
| AuthorAffiliation | Department of Pathology, Brigham & Women's Hospital, Boston, Massachusetts |
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| Keywords | H-2»-System Protozoa Animal model Antigen presentation Protozoal disease Pathogenesis Secretion Major histocompatibility system Rodentia Cytokine Leishmaniasis Infection Resistance Vertebrata Experimental disease Mammalia Mouse Leishmania T-Lymphocyte Rhizoflagellata Chimera |
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Reddit... Susceptibility or resistance to infection with Leishmania major correlates with the ability of mice to produce characteristic panels of lymphokines in response... |
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| SubjectTerms | Animals Antigen-Presenting Cells - physiology Bacterial Vaccines - immunology Biological and medical sciences Cytokines - secretion Experimental protozoal diseases and models Infectious diseases Interferon-gamma - secretion Interleukin-1 - secretion Interleukin-2 - secretion Interleukin-4 - secretion Leishmania major Leishmaniasis - immunology Medical sciences Mice Mice, Inbred BALB C Parasitic diseases Protozoal diseases T-Lymphocytes - immunology Tumor Necrosis Factor-alpha - secretion Vaccination |
| Title | Patterns of cytokine secretion in murine leishmaniasis: correlation with disease progression or resolution |
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