Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection

• Published in: Immunity (Cambridge, Mass.) Vol. 52; no. 6; pp. 1039 - 1056.e9
• Main Authors: Bosteels, Cedric, Neyt, Katrijn, Vanheerswynghels, Manon, van Helden, Mary J., Sichien, Dorine, Debeuf, Nincy, De Prijck, Sofie, Bosteels, Victor, Vandamme, Niels, Martens, Liesbet, Saeys, Yvan, Louagie, Els, Lesage, Manon, Williams, David L., Tang, Shiau-Choot, Mayer, Johannes U., Ronchese, Franca, Scott, Charlotte L., Hammad, Hamida, Guilliams, Martin, Lambrecht, Bart N.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 16.06.2020; Elsevier Limited
• Subjects: Antigen Presentation; Antigen-presenting cells; Antigens; Biomarkers; CD4 antigen; CD64; CD8 antigen; Cell culture; Cell Plasticity - immunology; Chemokines; convalescent serum; dendritic cell; Dendritic cells; Dendritic Cells - immunology; Dendritic Cells - metabolism; Disease Susceptibility; Fc receptor; Fc receptors; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Immunity; Immunophenotyping; inf-cDC2; Infections; Inflammation; Interferon; Interferon regulatory factor 4; Interferon Type I - metabolism; IRF8; Kinases; Lungs; Lymphocytes; Lymphocytes T; Macrophages; Macrophages - immunology; Macrophages - metabolism; monocyte; Monocytes; Monocytes - immunology; Monocytes - metabolism; Organ Specificity - immunology; Population; Receptors; Receptors, Fc - metabolism; Respirovirus Infections - etiology; Respirovirus Infections - metabolism; T-Lymphocyte Subsets - immunology; T-Lymphocyte Subsets - metabolism; Toll-like receptors; transcription factor; Transcription Factors; type 1 interferon; Viral infections; virus; Virus Diseases - genetics; Virus Diseases - immunology; Virus Diseases - metabolism; Virus Diseases - virology; Viruses; CD64; type 1 interferon; transcription factor; inf-cDC2; Fc receptor; convalescent serum; inflammation; monocyte; IRF8; virus; dendritic cell

The phenotypic and functional dichotomy between IRF8+ type 1 and IRF4+ type 2 conventional dendritic cells (cDC1s and cDC2s, respectively) is well accepted; it is unknown how robust this dichotomy is under inflammatory conditions, when additionally monocyte-derived cells (MCs) become competent antig...