Mephedrone (4-Methylmethcathinone): Acute Behavioral Effects, Hyperthermic, and Pharmacokinetic Profile in Rats

• Published in: Frontiers in Psychiatry Vol. 8; p. 306
• Main Authors: Šíchová, Klára, Pinterová, Nikola, Židková, Monika, Horsley, Rachel R., Lhotková, Eva, Štefková, Kristýna, Vejmola, Čestmír, Uttl, Libor, Balíková, Marie, Kuchař, Martin, Páleníček, Tomáš
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media SA 10.01.2018; Frontiers Media S.A
• Subjects: 4-methylmethcathinone; mephedrone; nor-mephedrone; open field; pharmacokinetics; prepulse inhibition; Psychiatry; RC435-571; open field; mephedrone; nor-mephedrone; Wistar rat; pharmacokinetics; prepulse inhibition; thermoregulation; 4-methylmethcathinone

Mephedrone (MEPH) is a synthetic cathinone derivative with effects that mimic MDMA and/or cocaine. Our study in male Wistar rats provides detailed investigations of MEPH's and its primary metabolite nor-mephedrone's (nor-MEPH) pharmacokinetics and bio-distribution to four different substra...