Comprehensive association analysis of nine candidate genes with serum 25-hydroxy vitamin D levels among healthy Caucasian subjects

• Published in: Human genetics Vol. 128; no. 5; pp. 549 - 556
• Main Authors: Bu, Feng-Xiao, Armas, Laura, Lappe, Joan, Zhou, Yu, Gao, Guimin, Wang, Hong-Wei, Recker, Robert, Zhao, Lan-Juan
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 01.11.2010; Springer-Verlag; Springer; Springer Nature B.V
• Subjects: Alfacalcidol; Analysis of Variance; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Calcifediol; Cholestanetriol 26-Monooxygenase - genetics; Classical genetics, quantitative genetics, hybrids; Confounding Factors (Epidemiology); Cross-Sectional Studies; Cytochrome; Cytochrome P-450; Cytochrome P450 Family 2; Disease; European Continental Ancestry Group - genetics; Fundamental and applied biological sciences. Psychology; Gene Function; Genes; Genetics of eukaryotes. Biological and molecular evolution; Genome-Wide Association Study; Health care; Human; Human Genetics; Humans; Metabolic Diseases; Metabolism; Molecular Medicine; Original Investigation; Osteoporosis; Polymorphism, Single Nucleotide; Polypeptides; Protein binding; Public health; Reference Values; Rickets; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D-Binding Protein - genetics; White people; Womens health; United States > US; Nebraska; Single Nucleotide Polymorphism; Discovery Cohort; Replication Cohort; Single Nucleotide Polymorphism Rs12794714; Single Nucleotide Polymorphism Marker; Association; Healthy subject; Vitamin D; Genetics; Serum; Candidate gene; Caucasoid

Vitamin D deficiency is a common public health problem in the US. It is related to the high risk of rickets, osteoporosis and other diseases. Currently, serum 25-hydroxy vitamin D [25(OH)D] concentration is the best indicator of vitamin D status, and determination of its deficiency or sufficiency. T...