Multi-tissue single-cell analysis deconstructs the complex programs of mouse natural killer and type 1 innate lymphoid cells in tissues and circulation

• Published in: Immunity (Cambridge, Mass.) Vol. 54; no. 6; pp. 1320 - 1337.e4
• Main Authors: McFarland, Adelle P., Yalin, Adam, Wang, Shuang-Yin, Cortez, Victor S., Landsberger, Tomer, Sudan, Raki, Peng, Vincent, Miller, Hannah L., Ricci, Biancamaria, David, Eyal, Faccio, Roberta, Amit, Ido, Colonna, Marco
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 08.06.2021; Elsevier Limited
• Subjects: Animals; Antigens; Blood circulation; Cell Line, Tumor; EOMES; Female; Gene expression; Gene sequencing; glycolysis; HOBIT; Humans; Immunity, Innate - immunology; innate lymphoid cells; Interferon; Intestine; Killer Cells, Natural - immunology; Liver; Lymphatic system; Lymphocytes; Lymphocytes - immunology; Lymphoid cells; Male; Mice; Mice, Inbred C57BL; Natural Cytotoxicity Triggering Receptor 1 - immunology; Natural killer cells; Neoplasms - immunology; NK Cell Lectin-Like Receptor Subfamily B - immunology; Populations; Proteins; Salivary gland; Salivary glands; Single-Cell Analysis - methods; single-cell RNA sequencing; Small intestine; Solid tumors; Spleen; TCF-1; tissue; Tissue analysis; Tissues; transcription factor; Transcription factors; Transcription Factors - immunology; tumor; Tumors; Uterus; γ-Interferon; single-cell RNA sequencing; EOMES; natural killer cells; transcription factor; TCF-1; tumor; glycolysis; tissue; innate lymphoid cells; HOBIT

Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1s) are heterogenous innate lymphocytes broadly defined in mice as Lin−NK1.1+NKp46+ cells that express the transcription factor T-BET and produce interferon-γ. The ILC1 definition primarily stems from studies on liver and small intestina...