Multi-tissue single-cell analysis deconstructs the complex programs of mouse natural killer and type 1 innate lymphoid cells in tissues and circulation

Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1s) are heterogenous innate lymphocytes broadly defined in mice as Lin−NK1.1+NKp46+ cells that express the transcription factor T-BET and produce interferon-γ. The ILC1 definition primarily stems from studies on liver and small intestina...

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Published inImmunity (Cambridge, Mass.) Vol. 54; no. 6; pp. 1320 - 1337.e4
Main Authors McFarland, Adelle P., Yalin, Adam, Wang, Shuang-Yin, Cortez, Victor S., Landsberger, Tomer, Sudan, Raki, Peng, Vincent, Miller, Hannah L., Ricci, Biancamaria, David, Eyal, Faccio, Roberta, Amit, Ido, Colonna, Marco
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 08.06.2021
Elsevier Limited
Subjects
Animals
Antigens
Blood circulation
Cell Line, Tumor
EOMES
Female
Gene expression
Gene sequencing
glycolysis
HOBIT
Humans
Immunity, Innate - immunology
innate lymphoid cells
Interferon
Intestine
Killer Cells, Natural - immunology
Liver
Lymphatic system
Lymphocytes
Lymphocytes - immunology
Lymphoid cells
Male
Mice
Mice, Inbred C57BL
Natural Cytotoxicity Triggering Receptor 1 - immunology
Natural killer cells
Neoplasms - immunology
NK Cell Lectin-Like Receptor Subfamily B - immunology
Populations
Proteins
Salivary gland
Salivary glands
Single-Cell Analysis - methods
single-cell RNA sequencing
Small intestine
Solid tumors
Spleen
TCF-1
tissue
Tissue analysis
Tissues
transcription factor
Transcription factors
Transcription Factors - immunology
tumor
Tumors
Uterus
γ-Interferon
single-cell RNA sequencing
EOMES
natural killer cells
transcription factor
TCF-1
tumor
glycolysis
tissue
innate lymphoid cells
HOBIT
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Abstract Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1s) are heterogenous innate lymphocytes broadly defined in mice as Lin−NK1.1+NKp46+ cells that express the transcription factor T-BET and produce interferon-γ. The ILC1 definition primarily stems from studies on liver and small intestinal populations. However, NK1.1+NKp46+ cells in the salivary glands, uterus, adipose, and other tissues exhibit nonuniform programs that differ from those of liver or intestinal ILC1s or NK cells. Here, we performed single-cell RNA sequencing on murine NK1.1+NKp46+ cells from blood, spleen, various tissues, and solid tumors. We identified gene expression programs of tissue-specific ILC1s, tissue-specific NK cells, and non-tissue-specific populations in blood, spleen, and other tissues largely corresponding to circulating cells. Moreover, we found that circulating NK cell programs were reshaped in tumor-bearing mice. Core programs of circulating and tumor NK cells paralleled conserved human NK cells signatures, advancing our understanding of the human NK-ILC1 spectrum. [Display omitted] •scRNA-seq of the ILC1-NK spectrum reveals circulation- and tissue-specific programs•Unique transcriptional programs define circulating and tissue NK cells and tissue ILC1s•NK cells that are not tissue specific evince programs ranging from immature to mature•Programs of NK cells within tumors are distinct from those of other NK cells How ILC1s and NK cells differ is not clear. McFarland et al. used single-cell RNA sequencing to elucidate gene signatures of mouse ILC1-NK cells from tissues, tumors, and the circulation. Data identify unique transcription factors, phenotypic markers, and metabolic features that distinguish tissue-resident NK cells and ILC1s from circulating NK cells.
AbstractList Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1s) are heterogenous innate lymphocytes broadly defined in mice as Lin NK1.1 NKp46 cells that express the transcription factor T-BET and produce interferon-γ. The ILC1 definition primarily stems from studies on liver and small intestinal populations. However, NK1.1 NKp46 cells in the salivary glands, uterus, adipose, and other tissues exhibit nonuniform programs that differ from those of liver or intestinal ILC1s or NK cells. Here, we performed single-cell RNA sequencing on murine NK1.1 NKp46 cells from blood, spleen, various tissues, and solid tumors. We identified gene expression programs of tissue-specific ILC1s, tissue-specific NK cells, and non-tissue-specific populations in blood, spleen, and other tissues largely corresponding to circulating cells. Moreover, we found that circulating NK cell programs were reshaped in tumor-bearing mice. Core programs of circulating and tumor NK cells paralleled conserved human NK cells signatures, advancing our understanding of the human NK-ILC1 spectrum.
Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1s) are heterogenous innate lymphocytes broadly defined in mice as Lin-NK1.1+NKp46+ cells that express the transcription factor T-BET and produce interferon-γ. The ILC1 definition primarily stems from studies on liver and small intestinal populations. However, NK1.1+NKp46+ cells in the salivary glands, uterus, adipose, and other tissues exhibit nonuniform programs that differ from those of liver or intestinal ILC1s or NK cells. Here, we performed single-cell RNA sequencing on murine NK1.1+NKp46+ cells from blood, spleen, various tissues, and solid tumors. We identified gene expression programs of tissue-specific ILC1s, tissue-specific NK cells, and non-tissue-specific populations in blood, spleen, and other tissues largely corresponding to circulating cells. Moreover, we found that circulating NK cell programs were reshaped in tumor-bearing mice. Core programs of circulating and tumor NK cells paralleled conserved human NK cells signatures, advancing our understanding of the human NK-ILC1 spectrum.Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1s) are heterogenous innate lymphocytes broadly defined in mice as Lin-NK1.1+NKp46+ cells that express the transcription factor T-BET and produce interferon-γ. The ILC1 definition primarily stems from studies on liver and small intestinal populations. However, NK1.1+NKp46+ cells in the salivary glands, uterus, adipose, and other tissues exhibit nonuniform programs that differ from those of liver or intestinal ILC1s or NK cells. Here, we performed single-cell RNA sequencing on murine NK1.1+NKp46+ cells from blood, spleen, various tissues, and solid tumors. We identified gene expression programs of tissue-specific ILC1s, tissue-specific NK cells, and non-tissue-specific populations in blood, spleen, and other tissues largely corresponding to circulating cells. Moreover, we found that circulating NK cell programs were reshaped in tumor-bearing mice. Core programs of circulating and tumor NK cells paralleled conserved human NK cells signatures, advancing our understanding of the human NK-ILC1 spectrum.
SummaryNatural killer (NK) cells and type 1 innate lymphoid cells (ILC1s) are heterogenous innate lymphocytes broadly defined in mice as Lin−NK1.1+NKp46+ cells that express the transcription factor T-BET and produce interferon-γ. The ILC1 definition primarily stems from studies on liver and small intestinal populations. However, NK1.1+NKp46+ cells in the salivary glands, uterus, adipose, and other tissues exhibit nonuniform programs that differ from those of liver or intestinal ILC1s or NK cells. Here, we performed single-cell RNA sequencing on murine NK1.1+NKp46+ cells from blood, spleen, various tissues, and solid tumors. We identified gene expression programs of tissue-specific ILC1s, tissue-specific NK cells, and non-tissue-specific populations in blood, spleen, and other tissues largely corresponding to circulating cells. Moreover, we found that circulating NK cell programs were reshaped in tumor-bearing mice. Core programs of circulating and tumor NK cells paralleled conserved human NK cells signatures, advancing our understanding of the human NK-ILC1 spectrum.
Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1s) are heterogenous innate lymphocytes broadly defined in mice as Lin−NK1.1+NKp46+ cells that express the transcription factor T-BET and produce interferon-γ. The ILC1 definition primarily stems from studies on liver and small intestinal populations. However, NK1.1+NKp46+ cells in the salivary glands, uterus, adipose, and other tissues exhibit nonuniform programs that differ from those of liver or intestinal ILC1s or NK cells. Here, we performed single-cell RNA sequencing on murine NK1.1+NKp46+ cells from blood, spleen, various tissues, and solid tumors. We identified gene expression programs of tissue-specific ILC1s, tissue-specific NK cells, and non-tissue-specific populations in blood, spleen, and other tissues largely corresponding to circulating cells. Moreover, we found that circulating NK cell programs were reshaped in tumor-bearing mice. Core programs of circulating and tumor NK cells paralleled conserved human NK cells signatures, advancing our understanding of the human NK-ILC1 spectrum. [Display omitted] •scRNA-seq of the ILC1-NK spectrum reveals circulation- and tissue-specific programs•Unique transcriptional programs define circulating and tissue NK cells and tissue ILC1s•NK cells that are not tissue specific evince programs ranging from immature to mature•Programs of NK cells within tumors are distinct from those of other NK cells How ILC1s and NK cells differ is not clear. McFarland et al. used single-cell RNA sequencing to elucidate gene signatures of mouse ILC1-NK cells from tissues, tumors, and the circulation. Data identify unique transcription factors, phenotypic markers, and metabolic features that distinguish tissue-resident NK cells and ILC1s from circulating NK cells.
Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1s) are heterogenous innate lymphocytes broadly defined in mice as Lin − NK1.1 + NKp46 + cells that express the transcription factor T-BET and produce interferon-γ. The ILC1 definition primarily stems from studies on liver and small intestinal populations. However, NK1.1 + NKp46 + cells in the salivary glands, uterus, adipose, and other tissues exhibit nonuniform programs that differ from those of liver or intestinal ILC1s or NK cells. Here, we performed single-cell RNA sequencing on murine NK1.1 + NKp46 + cells from blood, spleen, various tissues, and solid tumors. We identified gene expression programs of tissue-specific ILC1s, tissue-specific NK cells, and non-tissue-specific populations in blood, spleen, and other tissues largely corresponding to circulating cells. Moreover, we found that circulating NK cell programs were reshaped in tumor-bearing mice. Core programs of circulating and tumor NK cells paralleled conserved human NK cells signatures, advancing our understanding of the human NK-ILC1 spectrum. How ILC1s and NK cells differ is not clear. McFarland et al. used single-cell RNA sequencing to elucidate gene signatures of mouse ILC1-NK cells from tissues, tumors, and the circulation. Data identify unique transcription factors, phenotypic markers, and metabolic features that distinguish tissue-resident NK cells and ILC1s from circulating NK cells.
Author Sudan, Raki
Peng, Vincent
Ricci, Biancamaria
Landsberger, Tomer
David, Eyal
Wang, Shuang-Yin
Colonna, Marco
Amit, Ido
Miller, Hannah L.
Yalin, Adam
Faccio, Roberta
Cortez, Victor S.
McFarland, Adelle P.
AuthorAffiliation 3 Department of Orthopedics, Washington University School of Medicine, St. Louis, MO, USA
6 Lead contact
5 These authors contributed equally
1 Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA
2 Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
4 Shriners Children’s Hospital in St. Louis, St. Louis, MO, USA
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/33945787$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1016/j.immuni.2013.02.010
10.1038/nature11242
10.1016/j.celrep.2018.01.072
10.1016/j.cell.2013.05.016
10.1016/j.immuni.2019.02.022
10.1126/science.1247651
10.3892/mmr.2015.4243
10.1016/j.immuni.2018.04.018
10.1038/s41590-020-0728-z
10.1016/j.immuni.2014.09.005
10.1016/j.immuni.2019.11.004
10.4049/jimmunol.1502396
10.1038/ni.3489
10.1126/science.aaf6284
10.1126/science.aad0501
10.1016/j.immuni.2011.11.016
10.1016/j.cell.2020.02.004
10.1016/j.immuni.2018.05.013
10.1038/srep16269
10.1016/j.immuni.2018.09.009
10.1016/j.cell.2014.03.030
10.1038/s41596-019-0164-4
10.1186/s12859-018-2533-3
10.1371/journal.pone.0007830
10.3389/fimmu.2015.00646
10.1073/pnas.1521491113
10.1016/j.cell.2017.09.052
10.1038/nature13047
10.4049/jimmunol.1202702
10.1038/s41590-019-0425-y
10.1038/s41467-018-06918-3
10.1073/pnas.0508007102
10.3389/fimmu.2019.02278
10.1016/j.immuni.2019.01.012
10.1038/ni.3800
10.7554/eLife.01659
10.1128/MMBR.00009-09
10.1016/j.imlet.2016.07.005
10.1016/S0024-3205(01)01454-0
10.1111/imr.12600
10.1126/science.aad2035
10.1038/s41586-018-0282-0
10.1016/j.immuni.2016.03.007
10.1016/j.immuni.2015.12.007
10.1038/ni.3094
10.1016/j.immuni.2020.05.001
10.1016/j.jsbmb.2015.04.016
10.4049/jimmunol.1100833
10.1615/CritRevImmunol.2016017387
10.1128/MCB.24.13.5767-5775.2004
10.3389/fimmu.2014.00145
10.1016/j.celrep.2017.06.071
10.1016/j.cell.2015.10.072
10.1084/jem.20150809
10.1038/ni.3481
10.1111/imr.12710
10.4049/jimmunol.0901872
10.1038/nature11813
10.1084/jem.20131560
10.1016/j.immuni.2019.05.002
10.1038/nri.2017.76
10.1073/pnas.0611098104
10.1016/j.immuni.2010.08.002
10.1111/j.1600-065X.2006.00461.x
10.1126/science.aaa6566
10.4049/jimmunol.176.11.7028
10.1016/j.cell.2018.07.017
10.1016/j.cell.2018.01.004
10.1016/j.coi.2015.01.004
10.1016/j.cellsig.2011.03.020
10.1186/s13059-019-1812-2
10.1016/j.cell.2018.11.045
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Thu Apr 24 23:04:24 EDT 2025
Fri Feb 23 02:44:46 EST 2024
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Issue 6
Keywords single-cell RNA sequencing
EOMES
natural killer cells
transcription factor
TCF-1
tumor
glycolysis
tissue
innate lymphoid cells
HOBIT
Language English
License Copyright © 2021 Elsevier Inc. All rights reserved.
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content type line 14
content type line 23
AUTHOR CONTRIBUTIONS
Conceptualization, A.Y., V.S.C., I.A., and M.C.; methodology, A.Y., V.S.C., S.-Y.W., B.R., R.F., I.A., and M.C.; validation, A.P.M., R.S., V.P., and H.M.; formal analysis, A.P.M., A.Y., S.-Y.W., E.D., and T.L.; investigation, A.P.M., A.Y., V.C., S.-Y.W., H.M., and B.R.; writing, A.P.M., A.Y., I.A., and M.C.; visualization, A.P.M., A.Y., and S.-Y.W.; funding acquisition, I.A. and M.C.
ORCID 0000-0002-0301-2985
0000-0001-7534-1158
0000-0003-1574-6043
0000-0001-9683-4103
0000-0002-9101-818X
0000-0001-5222-4987
OpenAccessLink http://www.cell.com/article/S1074761321001369/pdf
PMID 33945787
PQID 2539177366
PQPubID 2031079
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_8312473
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PublicationTitle Immunity (Cambridge, Mass.)
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References Guy, Cardiff, Muller (bib29) 1992; 12
Montaldo, Vacca, Chiossone, Croxatto, Loiacono, Martini, Ferrero, Walzer, Moretta, Mingari (bib45) 2016; 6
Bald, Krummel, Smyth, Barry (bib3) 2020; 21
Baldassarre, Razinia, Burande, Lamsoul, Lutz, Calderwood (bib4) 2009; 4
Liu, Mendicino, Ning, Ghanekar, He, McGilvray, Shalev, Pivato, Clark, Phillips, Levy (bib42) 2006; 176
Adams, Sun (bib1) 2018; 286
Collins, Cella, Porter, Li, Gurewitz, Hong, Johnson, Oltz, Colonna (bib10) 2019; 176
Constantinides, McDonald, Verhoef, Bendelac (bib12) 2014; 508
Gordon, Chaix, Rupp, Wu, Madera, Sun, Lindsten, Reiner (bib28) 2012; 36
Vivier, Artis, Colonna, Diefenbach, Di Santo, Eberl, Koyasu, Locksley, McKenzie, Mebius (bib68) 2018; 174
Borges da Silva, Beura, Wang, Hanse, Gore, Scott, Walsh, Block, Fonseca, Yan (bib6) 2018; 559
Gao, Souza-Fonseca-Guimaraes, Bald, Ng, Young, Ngiow, Rautela, Straube, Waddell, Blake (bib26) 2017; 18
Robinette, Fuchs, Cortez, Lee, Wang, Durum, Gilfillan, Colonna (bib59) 2015; 16
Eberl, Colonna, Di Santo, McKenzie (bib22) 2015; 348
Jaitin, Kenigsberg, Keren-Shaul, Elefant, Paul, Zaretsky, Mildner, Cohen, Jung, Tanay, Amit (bib32) 2014; 343
Keskin, Allan, Rybalov, Andzelm, Stern, Kopcow, Koopman, Strominger (bib37) 2007; 104
Klose, Kiss, Schwierzeck, Ebert, Hoyler, d’Hargues, Göppert, Croxford, Waisman, Tanriver, Diefenbach (bib39) 2013; 494
Jarret, Jackson, Duizer, Healy, Zhao, Rone, Bielecki, Sefik, Roulis, Rice (bib33) 2020; 180
Chang, Curtis, Maggi, Faubert, Villarino, O’Sullivan, Huang, van der Windt, Blagih, Qiu (bib9) 2013; 153
Moratz, Hayman, Gu, Kehrl (bib46) 2004; 24
Safe, Jin, Morpurgo, Abudayyeh, Singh, Tjalkens (bib60) 2016; 157
Crinier, Milpied, Escalière, Piperoglou, Galluso, Balsamo, Spinelli, Cervera-Marzal, Ebbo, Girard-Madoux (bib16) 2018; 49
Nakamura, Yoshikawa, Yamaguchi, Kagota, Shinozuka, Kunitomo (bib48) 2002; 70
Papalexi, Satija (bib52) 2018; 18
Walker, Clark, Crisp, Barlow, Szeto, Ferreira, Rana, Jolin, Rodriguez-Rodriguez, Sivasubramaniam (bib69) 2019; 51
Klose, Flach, Möhle, Rogell, Hoyler, Ebert, Fabiunke, Pfeifer, Sexl, Fonseca-Pereira (bib40) 2014; 157
Keren-Shaul, Kenigsberg, Jaitin, David, Paul, Tanay, Amit (bib36) 2019; 14
Gibbons, Abeler-Dörner, Raine, Hwang, Jandke, Wencker, Deban, Rudd, Irving, Kehrl, Hayday (bib27) 2011; 187
van Helden, Goossens, Daussy, Mathieu, Faure, Marçais, Vandamme, Farla, Mayol, Viel (bib67) 2015; 212
Peng, Yin, Chhangawala, Xu, Leslie, Li (bib53) 2016; 354
Husain, Huang, Seth, Sukhatme (bib31) 2013; 191
Sun, Ma, Lanier (bib64) 2009; 183
Sojka, Plougastel-Douglas, Yang, Pak-Wittel, Artyomov, Ivanova, Zhong, Chase, Rothman, Yu (bib62) 2014; 3
Mackay, Minnich, Kragten, Liao, Nota, Seillet, Zaid, Man, Preston, Freestone (bib43) 2016; 352
Raulet, Marcus, Coscoy (bib58) 2017; 280
Leppilampi, Parkkila, Karttunen, Gut, Gros, Sjöblom (bib41) 2005; 102
Jeevan-Raj, Gehrig, Charmoy, Chennupati, Grandclément, Angelino, Delorenzi, Held (bib34) 2017; 20
Hu, Yan, Rao, Latha, Overwijk, Heimberger, Li (bib30) 2016; 35
Cortez, Robinette, Colonna (bib14) 2015; 32
Zou, Guo, Lv, Huang (bib75) 2015; 12
Yudanin, Schmitz, Flamar, Thome, Tait Wojno, Moeller, Schirmer, Latorre, Xavier, Farber (bib72) 2019; 50
Ni, Wang, Stojanovic, Zhang, Wincher, Bühler, Arnold, Correia, Winkler, Koch (bib49) 2020; 52
Adams, Lau, Fan, Rapp, Geary, Weizman, Diaz-Salazar, Sun (bib2) 2018; 48
Delconte, Shi, Sathe, Ushiki, Seillet, Minnich, Kolesnik, Rankin, Mielke, Zhang (bib19) 2016; 44
Weizman, Adams, Schuster, Krishna, Pritykin, Lau, Degli-Esposti, Leslie, Sun, O’Sullivan (bib70) 2017; 171
Diefenbach, Colonna, Koyasu (bib21) 2014; 41
Danilo, Chennupati, Silva, Siegert, Held (bib17) 2018; 22
Pikovskaya, Chaix, Rothman, Collins, Chen, Scipioni, Vivier, Reiner (bib54) 2016; 196
Rahim, Tu, Mahmoud, Wight, Abou-Samra, Lima, Makrigiannis (bib57) 2014; 5
Daussy, Faure, Mayol, Viel, Gasteiger, Charrier, Bienvenu, Henry, Debien, Hasan (bib18) 2014; 211
Filipovic, Chiossone, Vacca, Hamilton, Ingegnere, Doisne, Hawkes, Mingari, Sharkey, Moretta, Colucci (bib23) 2018; 9
Zhou, Yu, Zhao, Harty, Badovinac, Xue (bib73) 2010; 33
Fuchs, Vermi, Lee, Lonardi, Gilfillan, Newberry, Cella, Colonna (bib25) 2013; 38
Cella, Gamini, Sécca, Collins, Zhao, Peng, Robinette, Schettini, Zaitsev, Gordon (bib8) 2019; 20
Cortez, Cervantes-Barragan, Robinette, Bando, Wang, Geiger, Gilfillan, Fuchs, Vivier, Sun (bib15) 2016; 44
Nunn, Zhao, Zou, Summers, Guglielmo, Chidiac (bib51) 2011; 23
Pomaznoy, Ha, Peters (bib55) 2018; 19
Spinner, Uttenweiler-Joseph, Metais, Stella, Burlet-Schiltz, Moog-Lutz, Lamsoul, Lutz (bib63) 2015; 5
Nowarski, Jackson, Gagliani, de Zoete, Palm, Bailis, Low, Harman, Graham, Elinav, Flavell (bib50) 2015; 163
Johnstone, Smith, Cao, Burrows, Cross, Ling, Redvers, Doherty, Eckhardt, Natoli (bib35) 2015; 8
Xu, Cherrier, Chea, Vosshenrich, Serafini, Petit, Liu, Golub, Di Santo (bib71) 2019; 50
Nabekura, Riggan, Hildreth, O’Sullivan, Shibuya (bib47) 2020; 52
Klose, Artis (bib38) 2016; 17
Rabacal, Pabbisetty, Hoek, Cendron, Guo, Maseda, Sebzda (bib56) 2016; 113
Shui, Larange, Kim, Vela, Zahner, Cheroutre, Kronenberg (bib61) 2012; 488
Terrén, Orrantia, Vitallé, Zenarruzabeitia, Borrego (bib65) 2019; 10
Cortez, Colonna (bib13) 2016; 179
Tirosh, Izar, Prakadan, Wadsworth, Treacy, Trombetta, Rotem, Rodman, Lian, Murphy (bib66) 2016; 352
Mah, Cooper (bib44) 2016; 36
Fluck, Schaffhausen (bib24) 2009; 73
Baran, Bercovich, Sebe-Pedros, Lubling, Giladi, Chomsky, Meir, Hoichman, Lifshitz, Tanay (bib5) 2019; 20
Zook, Kee (bib74) 2016; 17
Colonna (bib11) 2018; 48
Böttcher, Bonavita, Chakravarty, Blees, Cabeza-Cabrerizo, Sammicheli, Rogers, Sahai, Zelenay, Reis E Sousa (bib7) 2018; 172
Di Santo, Vosshenrich (bib20) 2006; 214
Cortez (10.1016/j.immuni.2021.03.024_bib14) 2015; 32
Bald (10.1016/j.immuni.2021.03.024_bib3) 2020; 21
Cortez (10.1016/j.immuni.2021.03.024_bib13) 2016; 179
Borges da Silva (10.1016/j.immuni.2021.03.024_bib6) 2018; 559
Husain (10.1016/j.immuni.2021.03.024_bib31) 2013; 191
Safe (10.1016/j.immuni.2021.03.024_bib60) 2016; 157
Adams (10.1016/j.immuni.2021.03.024_bib1) 2018; 286
Baran (10.1016/j.immuni.2021.03.024_bib5) 2019; 20
Daussy (10.1016/j.immuni.2021.03.024_bib18) 2014; 211
Nunn (10.1016/j.immuni.2021.03.024_bib51) 2011; 23
Montaldo (10.1016/j.immuni.2021.03.024_bib45) 2016; 6
Tirosh (10.1016/j.immuni.2021.03.024_bib66) 2016; 352
Di Santo (10.1016/j.immuni.2021.03.024_bib20) 2006; 214
Mackay (10.1016/j.immuni.2021.03.024_bib43) 2016; 352
Cella (10.1016/j.immuni.2021.03.024_bib8) 2019; 20
Constantinides (10.1016/j.immuni.2021.03.024_bib12) 2014; 508
Liu (10.1016/j.immuni.2021.03.024_bib42) 2006; 176
Jarret (10.1016/j.immuni.2021.03.024_bib33) 2020; 180
Keskin (10.1016/j.immuni.2021.03.024_bib37) 2007; 104
Hu (10.1016/j.immuni.2021.03.024_bib30) 2016; 35
Eberl (10.1016/j.immuni.2021.03.024_bib22) 2015; 348
Rahim (10.1016/j.immuni.2021.03.024_bib57) 2014; 5
Baldassarre (10.1016/j.immuni.2021.03.024_bib4) 2009; 4
Sun (10.1016/j.immuni.2021.03.024_bib64) 2009; 183
Gordon (10.1016/j.immuni.2021.03.024_bib28) 2012; 36
Danilo (10.1016/j.immuni.2021.03.024_bib17) 2018; 22
Zhou (10.1016/j.immuni.2021.03.024_bib73) 2010; 33
Chang (10.1016/j.immuni.2021.03.024_bib9) 2013; 153
Pomaznoy (10.1016/j.immuni.2021.03.024_bib55) 2018; 19
Delconte (10.1016/j.immuni.2021.03.024_bib19) 2016; 44
Shui (10.1016/j.immuni.2021.03.024_bib61) 2012; 488
Klose (10.1016/j.immuni.2021.03.024_bib39) 2013; 494
Nabekura (10.1016/j.immuni.2021.03.024_bib47) 2020; 52
Robinette (10.1016/j.immuni.2021.03.024_bib59) 2015; 16
Böttcher (10.1016/j.immuni.2021.03.024_bib7) 2018; 172
Filipovic (10.1016/j.immuni.2021.03.024_bib23) 2018; 9
Adams (10.1016/j.immuni.2021.03.024_bib2) 2018; 48
Jeevan-Raj (10.1016/j.immuni.2021.03.024_bib34) 2017; 20
Johnstone (10.1016/j.immuni.2021.03.024_bib35) 2015; 8
Mah (10.1016/j.immuni.2021.03.024_bib44) 2016; 36
Xu (10.1016/j.immuni.2021.03.024_bib71) 2019; 50
Nakamura (10.1016/j.immuni.2021.03.024_bib48) 2002; 70
Raulet (10.1016/j.immuni.2021.03.024_bib58) 2017; 280
Vivier (10.1016/j.immuni.2021.03.024_bib68) 2018; 174
Guy (10.1016/j.immuni.2021.03.024_bib29) 1992; 12
Walker (10.1016/j.immuni.2021.03.024_bib69) 2019; 51
Terrén (10.1016/j.immuni.2021.03.024_bib65) 2019; 10
Fuchs (10.1016/j.immuni.2021.03.024_bib25) 2013; 38
Yudanin (10.1016/j.immuni.2021.03.024_bib72) 2019; 50
Colonna (10.1016/j.immuni.2021.03.024_bib11) 2018; 48
Papalexi (10.1016/j.immuni.2021.03.024_bib52) 2018; 18
Crinier (10.1016/j.immuni.2021.03.024_bib16) 2018; 49
Diefenbach (10.1016/j.immuni.2021.03.024_bib21) 2014; 41
Fluck (10.1016/j.immuni.2021.03.024_bib24) 2009; 73
van Helden (10.1016/j.immuni.2021.03.024_bib67) 2015; 212
Klose (10.1016/j.immuni.2021.03.024_bib40) 2014; 157
Weizman (10.1016/j.immuni.2021.03.024_bib70) 2017; 171
Keren-Shaul (10.1016/j.immuni.2021.03.024_bib36) 2019; 14
Rabacal (10.1016/j.immuni.2021.03.024_bib56) 2016; 113
Cortez (10.1016/j.immuni.2021.03.024_bib15) 2016; 44
Ni (10.1016/j.immuni.2021.03.024_bib49) 2020; 52
Spinner (10.1016/j.immuni.2021.03.024_bib63) 2015; 5
Zook (10.1016/j.immuni.2021.03.024_bib74) 2016; 17
Peng (10.1016/j.immuni.2021.03.024_bib53) 2016; 354
Gao (10.1016/j.immuni.2021.03.024_bib26) 2017; 18
Sojka (10.1016/j.immuni.2021.03.024_bib62) 2014; 3
Gibbons (10.1016/j.immuni.2021.03.024_bib27) 2011; 187
Zou (10.1016/j.immuni.2021.03.024_bib75) 2015; 12
Jaitin (10.1016/j.immuni.2021.03.024_bib32) 2014; 343
Pikovskaya (10.1016/j.immuni.2021.03.024_bib54) 2016; 196
Leppilampi (10.1016/j.immuni.2021.03.024_bib41) 2005; 102
Collins (10.1016/j.immuni.2021.03.024_bib10) 2019; 176
Moratz (10.1016/j.immuni.2021.03.024_bib46) 2004; 24
Nowarski (10.1016/j.immuni.2021.03.024_bib50) 2015; 163
Klose (10.1016/j.immuni.2021.03.024_bib38) 2016; 17
References_xml – volume: 176
  start-page: 7028
  year: 2006
  end-page: 7038
  ident: bib42
  article-title: Cytokine-induced hepatic apoptosis is dependent on FGL2/fibroleukin: the role of Sp1/Sp3 and STAT1/PU.1 composite cis elements
  publication-title: J. Immunol.
– volume: 559
  start-page: 264
  year: 2018
  end-page: 268
  ident: bib6
  article-title: The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8
  publication-title: Nature
– volume: 12
  start-page: 954
  year: 1992
  end-page: 961
  ident: bib29
  article-title: Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease
  publication-title: Mol. Cell. Biol.
– volume: 36
  start-page: 55
  year: 2012
  end-page: 67
  ident: bib28
  article-title: The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturation
  publication-title: Immunity
– volume: 280
  start-page: 93
  year: 2017
  end-page: 101
  ident: bib58
  article-title: Dysregulated cellular functions and cell stress pathways provide critical cues for activating and targeting natural killer cells to transformed and infected cells
  publication-title: Immunol. Rev.
– volume: 176
  start-page: 348
  year: 2019
  end-page: 360.e12
  ident: bib10
  article-title: Gene Regulatory Programs Conferring Phenotypic Identities to Human NK Cells
  publication-title: Cell
– volume: 20
  start-page: 206
  year: 2019
  ident: bib5
  article-title: MetaCell: analysis of single-cell RNA-seq data using K-nn graph partitions
  publication-title: Genome Biol.
– volume: 191
  start-page: 1486
  year: 2013
  end-page: 1495
  ident: bib31
  article-title: Tumor-derived lactate modifies antitumor immune response: effect on myeloid-derived suppressor cells and NK cells
  publication-title: J. Immunol.
– volume: 352
  start-page: 189
  year: 2016
  end-page: 196
  ident: bib66
  article-title: Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
  publication-title: Science
– volume: 153
  start-page: 1239
  year: 2013
  end-page: 1251
  ident: bib9
  article-title: Posttranscriptional control of T cell effector function by aerobic glycolysis
  publication-title: Cell
– volume: 9
  start-page: 4492
  year: 2018
  ident: bib23
  article-title: Molecular definition of group 1 innate lymphoid cells in the mouse uterus
  publication-title: Nat. Commun.
– volume: 32
  start-page: 71
  year: 2015
  end-page: 77
  ident: bib14
  article-title: Innate lymphoid cells: new insights into function and development
  publication-title: Curr. Opin. Immunol.
– volume: 163
  start-page: 1444
  year: 2015
  end-page: 1456
  ident: bib50
  article-title: Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis
  publication-title: Cell
– volume: 211
  start-page: 563
  year: 2014
  end-page: 577
  ident: bib18
  article-title: T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow
  publication-title: J. Exp. Med.
– volume: 214
  start-page: 35
  year: 2006
  end-page: 46
  ident: bib20
  article-title: Bone marrow versus thymic pathways of natural killer cell development
  publication-title: Immunol. Rev.
– volume: 174
  start-page: 1054
  year: 2018
  end-page: 1066
  ident: bib68
  article-title: Innate Lymphoid Cells: 10 Years On
  publication-title: Cell
– volume: 41
  start-page: 354
  year: 2014
  end-page: 365
  ident: bib21
  article-title: Development, differentiation, and diversity of innate lymphoid cells
  publication-title: Immunity
– volume: 113
  start-page: 5370
  year: 2016
  end-page: 5375
  ident: bib56
  article-title: Transcription factor KLF2 regulates homeostatic NK cell proliferation and survival
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 49
  start-page: 971
  year: 2018
  end-page: 986.e5
  ident: bib16
  article-title: High-Dimensional Single-Cell Analysis Identifies Organ-Specific Signatures and Conserved NK Cell Subsets in Humans and Mice
  publication-title: Immunity
– volume: 187
  start-page: 2067
  year: 2011
  end-page: 2071
  ident: bib27
  article-title: Cutting Edge: Regulator of G protein signaling-1 selectively regulates gut T cell trafficking and colitic potential
  publication-title: J. Immunol.
– volume: 10
  start-page: 2278
  year: 2019
  ident: bib65
  article-title: NK Cell Metabolism and Tumor Microenvironment
  publication-title: Front. Immunol.
– volume: 5
  start-page: 145
  year: 2014
  ident: bib57
  article-title: Ly49 receptors: innate and adaptive immune paradigms
  publication-title: Front. Immunol.
– volume: 508
  start-page: 397
  year: 2014
  end-page: 401
  ident: bib12
  article-title: A committed precursor to innate lymphoid cells
  publication-title: Nature
– volume: 16
  start-page: 306
  year: 2015
  end-page: 317
  ident: bib59
  article-title: Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets
  publication-title: Nat. Immunol.
– volume: 354
  start-page: 481
  year: 2016
  end-page: 484
  ident: bib53
  article-title: Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism
  publication-title: Science
– volume: 19
  start-page: 470
  year: 2018
  ident: bib55
  article-title: GOnet: a tool for interactive Gene Ontology analysis
  publication-title: BMC Bioinformatics
– volume: 12
  start-page: 6399
  year: 2015
  end-page: 6404
  ident: bib75
  article-title: Lipopolysaccharide-induced tumor necrosis factor-α factor enhances inflammation and is associated with cancer (Review)
  publication-title: Mol. Med. Rep.
– volume: 488
  start-page: 222
  year: 2012
  end-page: 225
  ident: bib61
  article-title: HVEM signalling at mucosal barriers provides host defence against pathogenic bacteria
  publication-title: Nature
– volume: 14
  start-page: 1841
  year: 2019
  end-page: 1862
  ident: bib36
  article-title: MARS-seq2.0: an experimental and analytical pipeline for indexed sorting combined with single-cell RNA sequencing
  publication-title: Nat. Protoc.
– volume: 20
  start-page: 980
  year: 2019
  end-page: 991
  ident: bib8
  article-title: Subsets of ILC3-ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues
  publication-title: Nat. Immunol.
– volume: 180
  start-page: 813
  year: 2020
  end-page: 814
  ident: bib33
  article-title: Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity
  publication-title: Cell
– volume: 17
  start-page: 765
  year: 2016
  end-page: 774
  ident: bib38
  article-title: Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis
  publication-title: Nat. Immunol.
– volume: 157
  start-page: 340
  year: 2014
  end-page: 356
  ident: bib40
  article-title: Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages
  publication-title: Cell
– volume: 35
  start-page: 325
  year: 2016
  end-page: 339
  ident: bib30
  article-title: The Duality of Fgl2 - Secreted Immune Checkpoint Regulator Versus Membrane-Associated Procoagulant: Therapeutic Potential and Implications
  publication-title: Int. Rev. Immunol.
– volume: 48
  start-page: 1172
  year: 2018
  end-page: 1182.e6
  ident: bib2
  article-title: Transcription Factor IRF8 Orchestrates the Adaptive Natural Killer Cell Response
  publication-title: Immunity
– volume: 286
  start-page: 23
  year: 2018
  end-page: 36
  ident: bib1
  article-title: Spatial and temporal coordination of antiviral responses by group 1 ILCs
  publication-title: Immunol. Rev.
– volume: 52
  start-page: 1075
  year: 2020
  end-page: 1087.e8
  ident: bib49
  article-title: Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1α Unleashes NK Cell Activity
  publication-title: Immunity
– volume: 48
  start-page: 1104
  year: 2018
  end-page: 1117
  ident: bib11
  article-title: Innate Lymphoid Cells: Diversity, Plasticity, and Unique Functions in Immunity
  publication-title: Immunity
– volume: 102
  start-page: 15247
  year: 2005
  end-page: 15252
  ident: bib41
  article-title: Carbonic anhydrase isozyme-II-deficient mice lack the duodenal bicarbonate secretory response to prostaglandin E2
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 494
  start-page: 261
  year: 2013
  end-page: 265
  ident: bib39
  article-title: A T-bet gradient controls the fate and function of CCR6-RORγt+ innate lymphoid cells
  publication-title: Nature
– volume: 3
  start-page: e01659
  year: 2014
  ident: bib62
  article-title: Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells
  publication-title: eLife
– volume: 212
  start-page: 2015
  year: 2015
  end-page: 2025
  ident: bib67
  article-title: Terminal NK cell maturation is controlled by concerted actions of T-bet and Zeb2 and is essential for melanoma rejection
  publication-title: J. Exp. Med.
– volume: 70
  start-page: 791
  year: 2002
  end-page: 798
  ident: bib48
  article-title: Characterization of mouse melanoma cell lines by their mortal malignancy using an experimental metastatic model
  publication-title: Life Sci.
– volume: 44
  start-page: 1127
  year: 2016
  end-page: 1139
  ident: bib15
  article-title: Transforming Growth Factor-β Signaling Guides the Differentiation of Innate Lymphoid Cells in Salivary Glands
  publication-title: Immunity
– volume: 171
  start-page: 795
  year: 2017
  end-page: 808.e12
  ident: bib70
  article-title: ILC1 Confer Early Host Protection at Initial Sites of Viral Infection
  publication-title: Cell
– volume: 4
  start-page: e7830
  year: 2009
  ident: bib4
  article-title: Filamins regulate cell spreading and initiation of cell migration
  publication-title: PLoS ONE
– volume: 23
  start-page: 1375
  year: 2011
  end-page: 1386
  ident: bib51
  article-title: Resistance to age-related, normal body weight gain in RGS2 deficient mice
  publication-title: Cell. Signal.
– volume: 18
  start-page: 35
  year: 2018
  end-page: 45
  ident: bib52
  article-title: Single-cell RNA sequencing to explore immune cell heterogeneity
  publication-title: Nat. Rev. Immunol.
– volume: 352
  start-page: 459
  year: 2016
  end-page: 463
  ident: bib43
  article-title: Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes
  publication-title: Science
– volume: 73
  start-page: 542
  year: 2009
  end-page: 563
  ident: bib24
  article-title: Lessons in signaling and tumorigenesis from polyomavirus middle T antigen
  publication-title: Microbiol. Mol. Biol. Rev.
– volume: 196
  start-page: 1449
  year: 2016
  end-page: 1454
  ident: bib54
  article-title: Cutting Edge: Eomesodermin Is Sufficient To Direct Type 1 Innate Lymphocyte Development into the Conventional NK Lineage
  publication-title: J. Immunol.
– volume: 22
  start-page: 2107
  year: 2018
  end-page: 2117
  ident: bib17
  article-title: Suppression of Tcf1 by Inflammatory Cytokines Facilitates Effector CD8 T Cell Differentiation
  publication-title: Cell Rep.
– volume: 6
  start-page: 646
  year: 2016
  ident: bib45
  article-title: Unique Eomes(+) NK Cell Subsets Are Present in Uterus and Decidua During Early Pregnancy
  publication-title: Front. Immunol.
– volume: 18
  start-page: 1004
  year: 2017
  end-page: 1015
  ident: bib26
  article-title: Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells
  publication-title: Nat. Immunol.
– volume: 24
  start-page: 5767
  year: 2004
  end-page: 5775
  ident: bib46
  article-title: Abnormal B-cell responses to chemokines, disturbed plasma cell localization, and distorted immune tissue architecture in Rgs1-/- mice
  publication-title: Mol. Cell. Biol.
– volume: 38
  start-page: 769
  year: 2013
  end-page: 781
  ident: bib25
  article-title: Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-γ-producing cells
  publication-title: Immunity
– volume: 20
  start-page: 613
  year: 2017
  end-page: 626
  ident: bib34
  article-title: The Transcription Factor Tcf1 Contributes to Normal NK Cell Development and Function by Limiting the Expression of Granzymes
  publication-title: Cell Rep.
– volume: 44
  start-page: 103
  year: 2016
  end-page: 115
  ident: bib19
  article-title: The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15
  publication-title: Immunity
– volume: 21
  start-page: 835
  year: 2020
  end-page: 847
  ident: bib3
  article-title: The NK cell-cancer cycle: advances and new challenges in NK cell-based immunotherapies
  publication-title: Nat. Immunol.
– volume: 172
  start-page: 1022
  year: 2018
  end-page: 1037.e14
  ident: bib7
  article-title: NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control
  publication-title: Cell
– volume: 183
  start-page: 2911
  year: 2009
  end-page: 2914
  ident: bib64
  article-title: Cutting edge: IL-15-independent NK cell response to mouse cytomegalovirus infection
  publication-title: J. Immunol.
– volume: 179
  start-page: 19
  year: 2016
  end-page: 24
  ident: bib13
  article-title: Diversity and function of group 1 innate lymphoid cells
  publication-title: Immunol. Lett.
– volume: 348
  start-page: aaa6566
  year: 2015
  ident: bib22
  article-title: Innate lymphoid cells. Innate lymphoid cells: a new paradigm in immunology
  publication-title: Science
– volume: 8
  start-page: 237
  year: 2015
  end-page: 251
  ident: bib35
  article-title: Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer
  publication-title: Dis. Model. Mech.
– volume: 157
  start-page: 48
  year: 2016
  end-page: 60
  ident: bib60
  article-title: Nuclear receptor 4A (NR4A) family - orphans no more
  publication-title: J. Steroid Biochem. Mol. Biol.
– volume: 50
  start-page: 1054
  year: 2019
  end-page: 1068.e3
  ident: bib71
  article-title: An Id2
  publication-title: Immunity
– volume: 5
  start-page: 16269
  year: 2015
  ident: bib63
  article-title: Substrates of the ASB2α E3 ubiquitin ligase in dendritic cells
  publication-title: Sci. Rep.
– volume: 52
  start-page: 96
  year: 2020
  end-page: 108.e9
  ident: bib47
  article-title: Type 1 Innate Lymphoid Cells Protect Mice from Acute Liver Injury via Interferon-γ Secretion for Upregulating Bcl-xL Expression in Hepatocytes
  publication-title: Immunity
– volume: 17
  start-page: 775
  year: 2016
  end-page: 782
  ident: bib74
  article-title: Development of innate lymphoid cells
  publication-title: Nat. Immunol.
– volume: 343
  start-page: 776
  year: 2014
  end-page: 779
  ident: bib32
  article-title: Massively parallel single-cell RNA-seq for marker-free decomposition of tissues into cell types
  publication-title: Science
– volume: 33
  start-page: 229
  year: 2010
  end-page: 240
  ident: bib73
  article-title: Differentiation and persistence of memory CD8(+) T cells depend on T cell factor 1
  publication-title: Immunity
– volume: 36
  start-page: 131
  year: 2016
  end-page: 147
  ident: bib44
  article-title: Metabolic Regulation of Natural Killer Cell IFN-γ Production
  publication-title: Crit. Rev. Immunol.
– volume: 50
  start-page: 505
  year: 2019
  end-page: 519.e4
  ident: bib72
  article-title: Spatial and Temporal Mapping of Human Innate Lymphoid Cells Reveals Elements of Tissue Specificity
  publication-title: Immunity
– volume: 104
  start-page: 3378
  year: 2007
  end-page: 3383
  ident: bib37
  article-title: TGFbeta promotes conversion of CD16+ peripheral blood NK cells into CD16- NK cells with similarities to decidual NK cells
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 51
  start-page: 104
  year: 2019
  end-page: 118.e7
  ident: bib69
  article-title: Polychromic Reporter Mice Reveal Unappreciated Innate Lymphoid Cell Progenitor Heterogeneity and Elusive ILC3 Progenitors in Bone Marrow
  publication-title: Immunity
– volume: 38
  start-page: 769
  year: 2013
  ident: 10.1016/j.immuni.2021.03.024_bib25
  article-title: Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-γ-producing cells
  publication-title: Immunity
  doi: 10.1016/j.immuni.2013.02.010
– volume: 488
  start-page: 222
  year: 2012
  ident: 10.1016/j.immuni.2021.03.024_bib61
  article-title: HVEM signalling at mucosal barriers provides host defence against pathogenic bacteria
  publication-title: Nature
  doi: 10.1038/nature11242
– volume: 22
  start-page: 2107
  year: 2018
  ident: 10.1016/j.immuni.2021.03.024_bib17
  article-title: Suppression of Tcf1 by Inflammatory Cytokines Facilitates Effector CD8 T Cell Differentiation
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2018.01.072
– volume: 153
  start-page: 1239
  year: 2013
  ident: 10.1016/j.immuni.2021.03.024_bib9
  article-title: Posttranscriptional control of T cell effector function by aerobic glycolysis
  publication-title: Cell
  doi: 10.1016/j.cell.2013.05.016
– volume: 35
  start-page: 325
  year: 2016
  ident: 10.1016/j.immuni.2021.03.024_bib30
  article-title: The Duality of Fgl2 - Secreted Immune Checkpoint Regulator Versus Membrane-Associated Procoagulant: Therapeutic Potential and Implications
  publication-title: Int. Rev. Immunol.
– volume: 50
  start-page: 1054
  year: 2019
  ident: 10.1016/j.immuni.2021.03.024_bib71
  article-title: An Id2RFP-Reporter Mouse Redefines Innate Lymphoid Cell Precursor Potentials
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.02.022
– volume: 343
  start-page: 776
  year: 2014
  ident: 10.1016/j.immuni.2021.03.024_bib32
  article-title: Massively parallel single-cell RNA-seq for marker-free decomposition of tissues into cell types
  publication-title: Science
  doi: 10.1126/science.1247651
– volume: 12
  start-page: 6399
  year: 2015
  ident: 10.1016/j.immuni.2021.03.024_bib75
  article-title: Lipopolysaccharide-induced tumor necrosis factor-α factor enhances inflammation and is associated with cancer (Review)
  publication-title: Mol. Med. Rep.
  doi: 10.3892/mmr.2015.4243
– volume: 48
  start-page: 1172
  year: 2018
  ident: 10.1016/j.immuni.2021.03.024_bib2
  article-title: Transcription Factor IRF8 Orchestrates the Adaptive Natural Killer Cell Response
  publication-title: Immunity
  doi: 10.1016/j.immuni.2018.04.018
– volume: 21
  start-page: 835
  year: 2020
  ident: 10.1016/j.immuni.2021.03.024_bib3
  article-title: The NK cell-cancer cycle: advances and new challenges in NK cell-based immunotherapies
  publication-title: Nat. Immunol.
  doi: 10.1038/s41590-020-0728-z
– volume: 41
  start-page: 354
  year: 2014
  ident: 10.1016/j.immuni.2021.03.024_bib21
  article-title: Development, differentiation, and diversity of innate lymphoid cells
  publication-title: Immunity
  doi: 10.1016/j.immuni.2014.09.005
– volume: 52
  start-page: 96
  year: 2020
  ident: 10.1016/j.immuni.2021.03.024_bib47
  article-title: Type 1 Innate Lymphoid Cells Protect Mice from Acute Liver Injury via Interferon-γ Secretion for Upregulating Bcl-xL Expression in Hepatocytes
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.11.004
– volume: 196
  start-page: 1449
  year: 2016
  ident: 10.1016/j.immuni.2021.03.024_bib54
  article-title: Cutting Edge: Eomesodermin Is Sufficient To Direct Type 1 Innate Lymphocyte Development into the Conventional NK Lineage
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1502396
– volume: 17
  start-page: 765
  year: 2016
  ident: 10.1016/j.immuni.2021.03.024_bib38
  article-title: Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3489
– volume: 354
  start-page: 481
  year: 2016
  ident: 10.1016/j.immuni.2021.03.024_bib53
  article-title: Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism
  publication-title: Science
  doi: 10.1126/science.aaf6284
– volume: 352
  start-page: 189
  year: 2016
  ident: 10.1016/j.immuni.2021.03.024_bib66
  article-title: Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
  publication-title: Science
  doi: 10.1126/science.aad0501
– volume: 36
  start-page: 55
  year: 2012
  ident: 10.1016/j.immuni.2021.03.024_bib28
  article-title: The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturation
  publication-title: Immunity
  doi: 10.1016/j.immuni.2011.11.016
– volume: 180
  start-page: 813
  year: 2020
  ident: 10.1016/j.immuni.2021.03.024_bib33
  article-title: Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity
  publication-title: Cell
  doi: 10.1016/j.cell.2020.02.004
– volume: 48
  start-page: 1104
  year: 2018
  ident: 10.1016/j.immuni.2021.03.024_bib11
  article-title: Innate Lymphoid Cells: Diversity, Plasticity, and Unique Functions in Immunity
  publication-title: Immunity
  doi: 10.1016/j.immuni.2018.05.013
– volume: 5
  start-page: 16269
  year: 2015
  ident: 10.1016/j.immuni.2021.03.024_bib63
  article-title: Substrates of the ASB2α E3 ubiquitin ligase in dendritic cells
  publication-title: Sci. Rep.
  doi: 10.1038/srep16269
– volume: 49
  start-page: 971
  year: 2018
  ident: 10.1016/j.immuni.2021.03.024_bib16
  article-title: High-Dimensional Single-Cell Analysis Identifies Organ-Specific Signatures and Conserved NK Cell Subsets in Humans and Mice
  publication-title: Immunity
  doi: 10.1016/j.immuni.2018.09.009
– volume: 157
  start-page: 340
  year: 2014
  ident: 10.1016/j.immuni.2021.03.024_bib40
  article-title: Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages
  publication-title: Cell
  doi: 10.1016/j.cell.2014.03.030
– volume: 14
  start-page: 1841
  year: 2019
  ident: 10.1016/j.immuni.2021.03.024_bib36
  article-title: MARS-seq2.0: an experimental and analytical pipeline for indexed sorting combined with single-cell RNA sequencing
  publication-title: Nat. Protoc.
  doi: 10.1038/s41596-019-0164-4
– volume: 19
  start-page: 470
  year: 2018
  ident: 10.1016/j.immuni.2021.03.024_bib55
  article-title: GOnet: a tool for interactive Gene Ontology analysis
  publication-title: BMC Bioinformatics
  doi: 10.1186/s12859-018-2533-3
– volume: 4
  start-page: e7830
  year: 2009
  ident: 10.1016/j.immuni.2021.03.024_bib4
  article-title: Filamins regulate cell spreading and initiation of cell migration
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0007830
– volume: 6
  start-page: 646
  year: 2016
  ident: 10.1016/j.immuni.2021.03.024_bib45
  article-title: Unique Eomes(+) NK Cell Subsets Are Present in Uterus and Decidua During Early Pregnancy
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2015.00646
– volume: 113
  start-page: 5370
  year: 2016
  ident: 10.1016/j.immuni.2021.03.024_bib56
  article-title: Transcription factor KLF2 regulates homeostatic NK cell proliferation and survival
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1521491113
– volume: 171
  start-page: 795
  year: 2017
  ident: 10.1016/j.immuni.2021.03.024_bib70
  article-title: ILC1 Confer Early Host Protection at Initial Sites of Viral Infection
  publication-title: Cell
  doi: 10.1016/j.cell.2017.09.052
– volume: 508
  start-page: 397
  year: 2014
  ident: 10.1016/j.immuni.2021.03.024_bib12
  article-title: A committed precursor to innate lymphoid cells
  publication-title: Nature
  doi: 10.1038/nature13047
– volume: 8
  start-page: 237
  year: 2015
  ident: 10.1016/j.immuni.2021.03.024_bib35
  article-title: Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer
  publication-title: Dis. Model. Mech.
– volume: 191
  start-page: 1486
  year: 2013
  ident: 10.1016/j.immuni.2021.03.024_bib31
  article-title: Tumor-derived lactate modifies antitumor immune response: effect on myeloid-derived suppressor cells and NK cells
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1202702
– volume: 20
  start-page: 980
  year: 2019
  ident: 10.1016/j.immuni.2021.03.024_bib8
  article-title: Subsets of ILC3-ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues
  publication-title: Nat. Immunol.
  doi: 10.1038/s41590-019-0425-y
– volume: 9
  start-page: 4492
  year: 2018
  ident: 10.1016/j.immuni.2021.03.024_bib23
  article-title: Molecular definition of group 1 innate lymphoid cells in the mouse uterus
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-06918-3
– volume: 102
  start-page: 15247
  year: 2005
  ident: 10.1016/j.immuni.2021.03.024_bib41
  article-title: Carbonic anhydrase isozyme-II-deficient mice lack the duodenal bicarbonate secretory response to prostaglandin E2
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0508007102
– volume: 10
  start-page: 2278
  year: 2019
  ident: 10.1016/j.immuni.2021.03.024_bib65
  article-title: NK Cell Metabolism and Tumor Microenvironment
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2019.02278
– volume: 50
  start-page: 505
  year: 2019
  ident: 10.1016/j.immuni.2021.03.024_bib72
  article-title: Spatial and Temporal Mapping of Human Innate Lymphoid Cells Reveals Elements of Tissue Specificity
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.01.012
– volume: 18
  start-page: 1004
  year: 2017
  ident: 10.1016/j.immuni.2021.03.024_bib26
  article-title: Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3800
– volume: 3
  start-page: e01659
  year: 2014
  ident: 10.1016/j.immuni.2021.03.024_bib62
  article-title: Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells
  publication-title: eLife
  doi: 10.7554/eLife.01659
– volume: 73
  start-page: 542
  year: 2009
  ident: 10.1016/j.immuni.2021.03.024_bib24
  article-title: Lessons in signaling and tumorigenesis from polyomavirus middle T antigen
  publication-title: Microbiol. Mol. Biol. Rev.
  doi: 10.1128/MMBR.00009-09
– volume: 179
  start-page: 19
  year: 2016
  ident: 10.1016/j.immuni.2021.03.024_bib13
  article-title: Diversity and function of group 1 innate lymphoid cells
  publication-title: Immunol. Lett.
  doi: 10.1016/j.imlet.2016.07.005
– volume: 12
  start-page: 954
  year: 1992
  ident: 10.1016/j.immuni.2021.03.024_bib29
  article-title: Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease
  publication-title: Mol. Cell. Biol.
– volume: 70
  start-page: 791
  year: 2002
  ident: 10.1016/j.immuni.2021.03.024_bib48
  article-title: Characterization of mouse melanoma cell lines by their mortal malignancy using an experimental metastatic model
  publication-title: Life Sci.
  doi: 10.1016/S0024-3205(01)01454-0
– volume: 280
  start-page: 93
  year: 2017
  ident: 10.1016/j.immuni.2021.03.024_bib58
  article-title: Dysregulated cellular functions and cell stress pathways provide critical cues for activating and targeting natural killer cells to transformed and infected cells
  publication-title: Immunol. Rev.
  doi: 10.1111/imr.12600
– volume: 352
  start-page: 459
  year: 2016
  ident: 10.1016/j.immuni.2021.03.024_bib43
  article-title: Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes
  publication-title: Science
  doi: 10.1126/science.aad2035
– volume: 559
  start-page: 264
  year: 2018
  ident: 10.1016/j.immuni.2021.03.024_bib6
  article-title: The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8+ T cells
  publication-title: Nature
  doi: 10.1038/s41586-018-0282-0
– volume: 44
  start-page: 1127
  year: 2016
  ident: 10.1016/j.immuni.2021.03.024_bib15
  article-title: Transforming Growth Factor-β Signaling Guides the Differentiation of Innate Lymphoid Cells in Salivary Glands
  publication-title: Immunity
  doi: 10.1016/j.immuni.2016.03.007
– volume: 44
  start-page: 103
  year: 2016
  ident: 10.1016/j.immuni.2021.03.024_bib19
  article-title: The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15
  publication-title: Immunity
  doi: 10.1016/j.immuni.2015.12.007
– volume: 16
  start-page: 306
  year: 2015
  ident: 10.1016/j.immuni.2021.03.024_bib59
  article-title: Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3094
– volume: 52
  start-page: 1075
  year: 2020
  ident: 10.1016/j.immuni.2021.03.024_bib49
  article-title: Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1α Unleashes NK Cell Activity
  publication-title: Immunity
  doi: 10.1016/j.immuni.2020.05.001
– volume: 157
  start-page: 48
  year: 2016
  ident: 10.1016/j.immuni.2021.03.024_bib60
  article-title: Nuclear receptor 4A (NR4A) family - orphans no more
  publication-title: J. Steroid Biochem. Mol. Biol.
  doi: 10.1016/j.jsbmb.2015.04.016
– volume: 187
  start-page: 2067
  year: 2011
  ident: 10.1016/j.immuni.2021.03.024_bib27
  article-title: Cutting Edge: Regulator of G protein signaling-1 selectively regulates gut T cell trafficking and colitic potential
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1100833
– volume: 36
  start-page: 131
  year: 2016
  ident: 10.1016/j.immuni.2021.03.024_bib44
  article-title: Metabolic Regulation of Natural Killer Cell IFN-γ Production
  publication-title: Crit. Rev. Immunol.
  doi: 10.1615/CritRevImmunol.2016017387
– volume: 24
  start-page: 5767
  year: 2004
  ident: 10.1016/j.immuni.2021.03.024_bib46
  article-title: Abnormal B-cell responses to chemokines, disturbed plasma cell localization, and distorted immune tissue architecture in Rgs1-/- mice
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.24.13.5767-5775.2004
– volume: 5
  start-page: 145
  year: 2014
  ident: 10.1016/j.immuni.2021.03.024_bib57
  article-title: Ly49 receptors: innate and adaptive immune paradigms
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2014.00145
– volume: 20
  start-page: 613
  year: 2017
  ident: 10.1016/j.immuni.2021.03.024_bib34
  article-title: The Transcription Factor Tcf1 Contributes to Normal NK Cell Development and Function by Limiting the Expression of Granzymes
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2017.06.071
– volume: 163
  start-page: 1444
  year: 2015
  ident: 10.1016/j.immuni.2021.03.024_bib50
  article-title: Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis
  publication-title: Cell
  doi: 10.1016/j.cell.2015.10.072
– volume: 212
  start-page: 2015
  year: 2015
  ident: 10.1016/j.immuni.2021.03.024_bib67
  article-title: Terminal NK cell maturation is controlled by concerted actions of T-bet and Zeb2 and is essential for melanoma rejection
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20150809
– volume: 17
  start-page: 775
  year: 2016
  ident: 10.1016/j.immuni.2021.03.024_bib74
  article-title: Development of innate lymphoid cells
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3481
– volume: 286
  start-page: 23
  year: 2018
  ident: 10.1016/j.immuni.2021.03.024_bib1
  article-title: Spatial and temporal coordination of antiviral responses by group 1 ILCs
  publication-title: Immunol. Rev.
  doi: 10.1111/imr.12710
– volume: 183
  start-page: 2911
  year: 2009
  ident: 10.1016/j.immuni.2021.03.024_bib64
  article-title: Cutting edge: IL-15-independent NK cell response to mouse cytomegalovirus infection
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0901872
– volume: 494
  start-page: 261
  year: 2013
  ident: 10.1016/j.immuni.2021.03.024_bib39
  article-title: A T-bet gradient controls the fate and function of CCR6-RORγt+ innate lymphoid cells
  publication-title: Nature
  doi: 10.1038/nature11813
– volume: 211
  start-page: 563
  year: 2014
  ident: 10.1016/j.immuni.2021.03.024_bib18
  article-title: T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20131560
– volume: 51
  start-page: 104
  year: 2019
  ident: 10.1016/j.immuni.2021.03.024_bib69
  article-title: Polychromic Reporter Mice Reveal Unappreciated Innate Lymphoid Cell Progenitor Heterogeneity and Elusive ILC3 Progenitors in Bone Marrow
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.05.002
– volume: 18
  start-page: 35
  year: 2018
  ident: 10.1016/j.immuni.2021.03.024_bib52
  article-title: Single-cell RNA sequencing to explore immune cell heterogeneity
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri.2017.76
– volume: 104
  start-page: 3378
  year: 2007
  ident: 10.1016/j.immuni.2021.03.024_bib37
  article-title: TGFbeta promotes conversion of CD16+ peripheral blood NK cells into CD16- NK cells with similarities to decidual NK cells
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0611098104
– volume: 33
  start-page: 229
  year: 2010
  ident: 10.1016/j.immuni.2021.03.024_bib73
  article-title: Differentiation and persistence of memory CD8(+) T cells depend on T cell factor 1
  publication-title: Immunity
  doi: 10.1016/j.immuni.2010.08.002
– volume: 214
  start-page: 35
  year: 2006
  ident: 10.1016/j.immuni.2021.03.024_bib20
  article-title: Bone marrow versus thymic pathways of natural killer cell development
  publication-title: Immunol. Rev.
  doi: 10.1111/j.1600-065X.2006.00461.x
– volume: 348
  start-page: aaa6566
  year: 2015
  ident: 10.1016/j.immuni.2021.03.024_bib22
  article-title: Innate lymphoid cells. Innate lymphoid cells: a new paradigm in immunology
  publication-title: Science
  doi: 10.1126/science.aaa6566
– volume: 176
  start-page: 7028
  year: 2006
  ident: 10.1016/j.immuni.2021.03.024_bib42
  article-title: Cytokine-induced hepatic apoptosis is dependent on FGL2/fibroleukin: the role of Sp1/Sp3 and STAT1/PU.1 composite cis elements
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.176.11.7028
– volume: 174
  start-page: 1054
  year: 2018
  ident: 10.1016/j.immuni.2021.03.024_bib68
  article-title: Innate Lymphoid Cells: 10 Years On
  publication-title: Cell
  doi: 10.1016/j.cell.2018.07.017
– volume: 172
  start-page: 1022
  year: 2018
  ident: 10.1016/j.immuni.2021.03.024_bib7
  article-title: NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control
  publication-title: Cell
  doi: 10.1016/j.cell.2018.01.004
– volume: 32
  start-page: 71
  year: 2015
  ident: 10.1016/j.immuni.2021.03.024_bib14
  article-title: Innate lymphoid cells: new insights into function and development
  publication-title: Curr. Opin. Immunol.
  doi: 10.1016/j.coi.2015.01.004
– volume: 23
  start-page: 1375
  year: 2011
  ident: 10.1016/j.immuni.2021.03.024_bib51
  article-title: Resistance to age-related, normal body weight gain in RGS2 deficient mice
  publication-title: Cell. Signal.
  doi: 10.1016/j.cellsig.2011.03.020
– volume: 20
  start-page: 206
  year: 2019
  ident: 10.1016/j.immuni.2021.03.024_bib5
  article-title: MetaCell: analysis of single-cell RNA-seq data using K-nn graph partitions
  publication-title: Genome Biol.
  doi: 10.1186/s13059-019-1812-2
– volume: 176
  start-page: 348
  year: 2019
  ident: 10.1016/j.immuni.2021.03.024_bib10
  article-title: Gene Regulatory Programs Conferring Phenotypic Identities to Human NK Cells
  publication-title: Cell
  doi: 10.1016/j.cell.2018.11.045
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Snippet Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1s) are heterogenous innate lymphocytes broadly defined in mice as Lin−NK1.1+NKp46+ cells that...
Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1s) are heterogenous innate lymphocytes broadly defined in mice as Lin NK1.1 NKp46 cells that...
SummaryNatural killer (NK) cells and type 1 innate lymphoid cells (ILC1s) are heterogenous innate lymphocytes broadly defined in mice as Lin−NK1.1+NKp46+ cells...
Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1s) are heterogenous innate lymphocytes broadly defined in mice as Lin-NK1.1+NKp46+ cells that...
Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1s) are heterogenous innate lymphocytes broadly defined in mice as Lin − NK1.1 + NKp46 + cells...
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SubjectTerms Animals
Antigens
Blood circulation
Cell Line, Tumor
EOMES
Female
Gene expression
Gene sequencing
glycolysis
HOBIT
Humans
Immunity, Innate - immunology
innate lymphoid cells
Interferon
Intestine
Killer Cells, Natural - immunology
Liver
Lymphatic system
Lymphocytes
Lymphocytes - immunology
Lymphoid cells
Male
Mice
Mice, Inbred C57BL
Natural Cytotoxicity Triggering Receptor 1 - immunology
Natural killer cells
Neoplasms - immunology
NK Cell Lectin-Like Receptor Subfamily B - immunology
Populations
Proteins
Salivary gland
Salivary glands
Single-Cell Analysis - methods
single-cell RNA sequencing
Small intestine
Solid tumors
Spleen
TCF-1
tissue
Tissue analysis
Tissues
transcription factor
Transcription factors
Transcription Factors - immunology
tumor
Tumors
Uterus
γ-Interferon
Title Multi-tissue single-cell analysis deconstructs the complex programs of mouse natural killer and type 1 innate lymphoid cells in tissues and circulation
URI https://dx.doi.org/10.1016/j.immuni.2021.03.024
https://www.ncbi.nlm.nih.gov/pubmed/33945787
https://www.proquest.com/docview/2539177366
https://www.proquest.com/docview/2522393937
https://pubmed.ncbi.nlm.nih.gov/PMC8312473
Volume 54
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