Bilirubin and its Oxidation Products Damage Brain White Matter

• Published in: Journal of cerebral blood flow and metabolism Vol. 34; no. 11; pp. 1837 - 1847
• Main Authors: Lakovic, Katarina, Ai, Jinglu, D'Abbondanza, Josephine, Tariq, Asma, Sabri, Mohammed, Alarfaj, Abdullah K, Vasdev, Punarjot, Macdonald, Robert Loch
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.11.2014; Sage Publications Ltd; Nature Publishing Group
• Subjects: Animals; Axons - metabolism; Axons - pathology; Bilirubin - metabolism; Brain Injuries - metabolism; Brain Injuries - pathology; Cerebral Cortex - metabolism; Cerebral Cortex - pathology; Cerebral Hemorrhage - metabolism; Cerebral Hemorrhage - pathology; Male; Mice; Original; Oxidation-Reduction; Stroke - metabolism; Stroke - pathology; intracerebral hemorrhage; white matter; bilirubin toxicity; mice

Brain injury after intracerebral hemorrhage (ICH) occurs in cortex and white matter and may be mediated by blood breakdown products, including hemoglobin and heme. Effects of blood breakdown products, bilirubin and bilirubin oxidation products, have not been widely investigated in adult brain. Here,...