ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation - Miao, Guangyan; Zhao, Hongyu; Li, Yan; Ji, Mingming; Chen, Yong; Shi, Yi; Bi, Yuhai; Wang, Peihui; Zhang, Hong (Developmental cell, 2021)
Keywords: Autophagosomes - metabolism; Autophagy; Autophagy-Related Proteins - metabolism; COVID-19; COVID-19 - metabolism; COVID-19 - virology; DMV; HEK293 Cells; HeLa Cells; HOPS; Humans; Lysosomes - metabolism; ORF3a; Protein Binding; SARS-CoV-2; SARS-CoV-2 - metabolism; SARS-CoV-2 - pathogenicity; SNARE; SNARE Proteins - metabolism; Vesicular Transport Proteins - metabolism; Viroporin Proteins - genetics; Viroporin Proteins - metabolism; COVID-19; SARS-CoV-2; autophagy; HOPS; DMV; ORF3a; SNARE