Altering cell death pathways as an approach to cure HIV infection

• Published in: Cell death & disease Vol. 4; no. 7; p. e718
• Main Authors: Badley, A D, Sainski, A, Wightman, F, Lewin, S R
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.07.2013; Springer Nature B.V; Nature Publishing Group
• Subjects: 631/326/596/2558; 631/80/82/23; 692/699/255/1901; Animals; Anti-HIV Agents - pharmacology; Anti-HIV Agents - therapeutic use; Antibodies; Apoptosis; Biochemistry; Biomedical and Life Sciences; CD4-Positive T-Lymphocytes - physiology; CD4-Positive T-Lymphocytes - virology; Cell Biology; Cell Culture; Cell death; Genetic Therapy; HIV Infections - immunology; HIV Infections - therapy; HIV-1 - physiology; Host-Pathogen Interactions; Human immunodeficiency virus; Humans; Immunology; Immunotherapy; Life Sciences; Review; Virus Latency; Bcl2; apoptosis; HIV cure; Casp8p41; latency

Recent cases of successful control of human immunodeficiency virus (HIV) by bone marrow transplant in combination with suppressive antiretroviral therapy (ART) and very early initiation of ART have provided proof of concept that HIV infection might now be cured. Current efforts focusing on gene ther...