Antiviral effects of micafungin against pteropine orthoreovirus, an emerging zoonotic virus carried by bats

• Published in: Virus Research Vol. 339; p. 199248
• Main Authors: Hondo, Eiichi, Katta, Tetsufumi, Sato, Ayato, Kadofusa, Naoya, Ishibashi, Tomoki, Shimoda, Hiroshi, Katoh, Hirokazu, Iida, Atsuo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 02.01.2024; Elsevier BV; Elsevier
• Subjects: Animals; antifungal agents; Antiviral; Antiviral Agents - pharmacology; antiviral properties; Chiroptera; Chlorocebus aethiops; Ebolavirus; endoplasmic reticulum stress; Fda-approved drug; foxes; genome; HEK293 Cells; Humans; Infectious and parasitic diseases; Micafungin; Microbiology; Nipah henipavirus; Orthocoronavirinae; Orthoreovirus; Orthoreovirus - genetics; Pteropine orthoreovirus; QR1-502; quantitative polymerase chain reaction; RC109-216; Reoviridae Infections; Rhinolophus; South East Asia; species; stress response; transcriptome; Vero Cells; Viruses; South East Asia; Antiviral; Pteropine orthoreovirus; Micafungin; Fda-approved drug

•A library of 2943 FDA-approved drugs was screened to find potential antiviral drugs of pteropine orthoreovirus.•Six hit compounds dramatically inhibited viral replication in vitro.•Micafungin possessed antiviral activity to multiple strains of PRV.•Micafungin suppressed PRV release in human cells....