A Disinhibitory Circuit for Contextual Modulation in Primary Visual Cortex

• Published in: Neuron (Cambridge, Mass.) Vol. 108; no. 6; pp. 1181 - 1193.e8
• Main Authors: Keller, Andreas J., Dipoppa, Mario, Roth, Morgane M., Caudill, Matthew S., Ingrosso, Alessandro, Miller, Kenneth D., Scanziani, Massimo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 23.12.2020; Elsevier Limited
• Subjects: Animals; Calcium - metabolism; canonical disinhibitory circuit; computational modeling; Computational neuroscience; contextual modulation; figure-ground segregation; inhibitory neurons; Intestine; Mice; Models, Neurological; Neural Inhibition - physiology; Neurons; Neurons - metabolism; Photic Stimulation; pop-out effects; recurrent neural network; saliency; Somatostatin; Somatostatin - metabolism; stabilized supralinear network; Vasoactive agents; Vasoactive intestinal peptide; Vasoactive Intestinal Peptide - metabolism; Visual cortex; Visual Cortex - metabolism; Visual Cortex - physiology; Visual pathways; Visual Pathways - metabolism; Visual Pathways - physiology; Visual Perception - physiology; Visual stimuli; figure-ground segregation; recurrent neural network; visual cortex; canonical disinhibitory circuit; computational modeling; contextual modulation; pop-out effects; saliency; inhibitory neurons; stabilized supralinear network

Context guides perception by influencing stimulus saliency. Accordingly, in visual cortex, responses to a stimulus are modulated by context, the visual scene surrounding the stimulus. Responses are suppressed when stimulus and surround are similar but not when they differ. The underlying mechanisms...