Phagocytosis of apoptotic cells: a matter of balance

Efficient clearance of apoptotic cells is required to control homeostasis in normal and pathological circumstances, and inappropriate clearance of cell corpses may lead to autoimmune diseases and inflammation. The multiplicity of phagocytotic mechanisms points to the relevance of removing apoptotic...

Full description

Saved in:
Bibliographic Details
Published inCellular and molecular life sciences : CMLS Vol. 62; no. 14; pp. 1532 - 1546
Main Authors de Almeida, C J G, Linden, R
Format Journal Article
LanguageEnglish
Published Switzerland Springer Nature B.V 01.07.2005
Birkhäuser-Verlag
Subjects
Animals
Apoptosis
Autoimmune diseases
Humans
Models, Biological
Phagocytosis
Receptors, Cell Surface - physiology
Review
Signal Transduction - physiology
Online AccessGet full text

Cover

More Information
Summary:Efficient clearance of apoptotic cells is required to control homeostasis in normal and pathological circumstances, and inappropriate clearance of cell corpses may lead to autoimmune diseases and inflammation. The multiplicity of phagocytotic mechanisms points to the relevance of removing apoptotic cells. A variety of surface molecules present in either the apoptotic bodies or phagocytes help in attachment and initiation of engulfment. Nonetheless, uncontrolled phagocytosis of apoptotic cells and other particles may lead to tissue injury; therefore, negative signals are important in balancing phagocytotic activity. This review aims at a systematic examination of positive and negative signals that modulate the uptake of apoptotic bodies and the signaling mechanisms involved in the clearance of apoptotic cells.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
ObjectType-Review-3
ISSN:1420-682X
1420-9071
DOI:10.1007/s00018-005-4511-y