Interleukin-33 Induces the Enzyme Tryptophan Hydroxylase 1 to Promote Inflammatory Group 2 Innate Lymphoid Cell-Mediated Immunity

• Published in: Immunity (Cambridge, Mass.) Vol. 52; no. 4; pp. 606 - 619.e6
• Main Authors: Flamar, Anne-Laure, Klose, Christoph S.N., Moeller, Jesper B., Mahlakõiv, Tanel, Bessman, Nicholas J., Zhang, Wen, Moriyama, Saya, Stokic-Trtica, Vladislava, Rankin, Lucille C., Putzel, Gregory Garbès, Rodewald, Hans-Reimer, He, Zhengxiang, Chen, Lili, Lira, Sergio A., Karsenty, Gerard, Artis, David
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 14.04.2020; Elsevier Limited
• Subjects: Animals; Cell Lineage - genetics; Cell Lineage - immunology; Cell-mediated immunity; Cytokines; Disease Susceptibility; Enzymes; Gene expression; Gene Expression Regulation - immunology; Gene sequencing; group 2 innate lymphoid cells; helminth infection; Homeostasis; IL-33; ILC2s; Immunity; Immunity, Cellular; Immunity, Innate; Immunity, Mucosal; Inducible T-Cell Co-Stimulator Protein - genetics; Inducible T-Cell Co-Stimulator Protein - immunology; Infections; Inflammation; inflammatory ILC2s; Interleukin-33 - genetics; Interleukin-33 - immunology; Interleukins; Larva - growth & development; Larva - immunology; Larva - pathogenicity; Lymph Nodes - immunology; Lymph Nodes - parasitology; Lymphatic system; Lymphocytes; Lymphocytes T; Lymphoid cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Mucosa; Mucosal immunity; Nippostrongylus - growth & development; Nippostrongylus - immunology; Nippostrongylus - pathogenicity; Primary Cell Culture; Ribonucleic acid; RNA; Rodents; Sequence analysis; Signal Transduction; Stimulators; Strongylida Infections - genetics; Strongylida Infections - immunology; Strongylida Infections - parasitology; Strongylida Infections - pathology; T-Lymphocyte Subsets - classification; T-Lymphocyte Subsets - immunology; T-Lymphocyte Subsets - parasitology; Tph1; Tryptophan; Tryptophan hydroxylase; Tryptophan Hydroxylase - genetics; Tryptophan Hydroxylase - immunology; tryptophan hydroxylase 1; type 2 immunity; inflammatory ILC2s; Tph1; helminth infection; group 2 innate lymphoid cells; tryptophan hydroxylase 1; ILC2s; IL-33; type 2 immunity

Group 2 innate lymphoid cells (ILC2s) regulate immunity, inflammation, and tissue homeostasis. Two distinct subsets of ILC2s have been described: steady-state natural ILC2s and inflammatory ILC2s, which are elicited following helminth infection. However, how tissue-specific cues regulate these two s...