Nucleoside antibiotics: biosynthesis, regulation, and biotechnology

• Published in: Trends in microbiology (Regular ed.) Vol. 23; no. 2; pp. 110 - 119
• Main Authors: Niu, Guoqing, Tan, Huarong
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2015
• Subjects: Aminoglycosides - biosynthesis; Aminoglycosides - chemistry; Anti-Bacterial Agents - biosynthesis; Anti-Bacterial Agents - chemistry; antibiotic resistance; antibiotics; Antifungal Agents - chemistry; Antifungal Agents - metabolism; Antiviral Agents - chemistry; Antiviral Agents - metabolism; biosynthesis; Biotechnology; Cytidine - analogs & derivatives; Cytidine - biosynthesis; Cytosine - analogs & derivatives; Cytosine - biosynthesis; Cytosine - chemistry; engineering; enzymatic reactions; Genetic Engineering; Internal Medicine; nucleoside antibiotics; nucleosides; Nucleosides - biosynthesis; Nucleosides - chemistry; Nucleosides - metabolism; pathogens; Pyrimidine Nucleosides - biosynthesis; Pyrimidine Nucleosides - chemistry; regulation; nucleoside antibiotics; regulation; genetic engineering; biosynthesis

•Nucleoside antibiotics are broad-spectrum antibiotics with unique structural features.•Unusual enzymatic reactions occur in the biosynthesis of nucleoside antibiotics.•Biosynthesis of nucleoside antibiotics is regulated at multiple levels.•Biosynthetic studies may assist with rational design of nov...