Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis

• Published in: Immunity (Cambridge, Mass.) Vol. 50; no. 6; pp. 1401 - 1411.e4
• Main Authors: Wu, Congqing, Lu, Wei, Zhang, Yan, Zhang, Guoying, Shi, Xuyan, Hisada, Yohei, Grover, Steven P., Zhang, Xinyi, Li, Lan, Xiang, Binggang, Shi, Jumei, Li, Xiang-An, Daugherty, Alan, Smyth, Susan S., Kirchhofer, Daniel, Shiroishi, Toshihiko, Shao, Feng, Mackman, Nigel, Wei, Yinan, Li, Zhenyu
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 18.06.2019; Elsevier Limited
• Subjects: Animals; Apoptosis; Bacterial infections; Bacterial Infections - complications; Bacterial Infections - microbiology; Biomarkers; Blood; Blood Coagulation; Cascades; caspase; Caspases - metabolism; Cell activation; Cell culture; Cell death; Cell-Derived Microparticles - immunology; Cell-Derived Microparticles - metabolism; Cloning; Clotting; Coagulation; Cytotoxicity; DIC; Disease Models, Animal; E coli; Gram-negative bacteria; GSDMD; Humans; inflammasome; Inflammasomes; Inflammasomes - metabolism; Lipopolysaccharides; Lipopolysaccharides - immunology; LPS; macrophage; Macrophages; Macrophages - immunology; Macrophages - metabolism; Mice; Microscopy; Monocytes - immunology; Monocytes - metabolism; Mortality; Pathogenesis; Pharmacology; Proteins; Pyroptosis; Secretion; Sepsis; Signal Transduction; Thromboembolism; Thromboplastin - metabolism; Thrombosis; Thrombosis - blood; Thrombosis - etiology; Thrombosis - metabolism; Thrombosis - mortality; Time series; Tissue factor; GSDMD; pyroptosis; tissue factor; inflammasome; macrophage; coagulation; LPS; sepsis; caspase; DIC

Inflammasome activation and subsequent pyroptosis are critical defense mechanisms against microbes. However, overactivation of inflammasome leads to death of the host. Although recent studies have uncovered the mechanism of pyroptosis following inflammasome activation, how pyroptotic cell death driv...