Impaired structural hippocampal plasticity is associated with emotional and memory deficits in the olfactory bulbectomized rat

• Published in: Neuroscience Vol. 236; pp. 233 - 243
• Main Authors: Morales-Medina, J.C., Juarez, I., Venancio-García, E., Cabrera, S.N., Menard, C., Yu, W., Flores, G., Mechawar, N., Quirion, R.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 16.04.2013; Elsevier
• Subjects: adult neurogenesis; Affective Symptoms - pathology; Affective Symptoms - physiopathology; animal model; Animals; Biological and medical sciences; dendritic morphology; Depression - pathology; Depression - physiopathology; depression-like behavior; Disease Models, Animal; Fundamental and applied biological sciences. Psychology; Golgi–Cox stain; Hippocampus - pathology; Hippocampus - physiopathology; Immunohistochemistry; Male; Memory Disorders - pathology; Memory Disorders - physiopathology; Neurology; Neuronal Plasticity - physiology; OBX rat; Olfactory Bulb - surgery; Rats; Rats, Sprague-Dawley; Vertebrates: nervous system and sense organs; PBS; adult neurogenesis; MWM; Golgi–Cox stain; DG; OBX; IHC; FST; depression-like behavior; PirC; dendritic morphology; OFT; animal model; TDL; BrdU; OBX rat; Morris water maze; piriform cortex; total dendritic length; phosphate-buffered saline; olfactory bulbectomized; immunohistochemical; dentate gyrus; bromodeoxyuridine; open field test; forced swim test; Animal model; Memory disorder; Cognitive disorder; Rat; Rodentia; Central nervous system; Neurogenesis; Encephalon; Vertebrata; Mammalia; Animal; Morphology; Plasticity; Behavior; Golgi―Cox stain; Hippocampus

► OBX increases hyperlocomotion in the open field test. ► OBX induces immobility in the forced swim test. ► OBX disrupts spatial memory acquisition in the Morris water test. ► OBX rearranges neuronal arborization in the hippocampus and piriform cortex. ► OBX decreases the number of proliferative cel...