Genomewide Association Study of Acute Anterior Uveitis Identifies New Susceptibility Loci

• Published in: Investigative ophthalmology & visual science Vol. 61; no. 6; p. 3
• Main Authors: Huang, Xiu-Feng, Li, Zhixiu, De Guzman, Erika, Robinson, Philip, Gensler, Lianne, Ward, Michael M., Rahbar, Mohammad Hossein, Lee, MinJae, Weisman, Michael H., Macfarlane, Gary J., Jones, Gareth T., Klingberg, Eva, Forsblad-d'Elia, Helena, McCluskey, Peter, Wakefield, Denis, Coombes, Jeff S., Fiatarone Singh, Maria A., Mavros, Yorgi, Vlahovich, Nicole, Hughes, David C., Marzo-Ortega, Helena, Van der Horste-Bruinsma, Irene, O'Shea, Finbar, Martin, Tammy M., Rosenbaum, James, Breban, Maxime, Jin, Zi-Bing, Leo, Paul, Reveille, John D., Wordsworth, B. Paul, Brown, Matthew A.
• Format: Journal Article
• Language: English
• Published: United States Association for Research in Vision and Ophthalmology 03.06.2020; The Association for Research in Vision and Ophthalmology
• Subjects: acute anterior uveitis; Acute Disease; Adult; ankylosing spondylitis; Case-Control Studies; Clinical Medicine; discovery; Ecology, environment; epidemiology; Female; gene-expression; Genetic Loci - genetics; Genetic Predisposition to Disease - genetics; genetic risk scores; Genetics; Genome-Wide Association Study; Genotyping Techniques; GWAS; Health; heritability; HLA-B Antigens - genetics; hla-b27; Humans; Klinisk medicin; Life Sciences; Male; Middle Aged; Odds Ratio; Ophthalmology; Polymorphism, Single Nucleotide; population; prediction; protooncogene; Spondylitis, Ankylosing - genetics; Uveitis, Anterior - genetics; variants; wide association; GWAS; genetic risk scores; acute anterior uveitis; acute anterior uveitis ankylosing spondylitis GWAS heritability genetic risk scores; ankylosing spondylitis; heritability

Acute anterior uveitis (AAU) is a common intraocular inflammatory disease. AAU occurs in 30% to 50% of patients with ankylosing spondylitis (AS), and both conditions are strongly associated with human leukocyte antigen (HLA)-B27, implying a shared etiology. This study aims to apply genomewide associ...