The Not so Good, the Bad and the Ugly: Differential Bacterial Adhesion and Invasion Mediated by Salmonella PagN Allelic Variants

• Published in: Microorganisms (Basel) Vol. 8; no. 4; p. 489
• Main Authors: Wu, Yanping, Hu, Qiaoyun, Dehinwal, Ruchika, Rakov, Alexey V, Grams, Nicholas, Clemens, Erin C, Hofmann, Jennifer, Okeke, Iruka N, Schifferli, Dieter M
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30.03.2020; MDPI
• Subjects: adhesin; Adhesion; Alleles; Amino acids; Bacteria; Biological evolution; Cell culture; Cloning; Colonization; E coli; Ecological adaptation; Enterocytes; Epidermal growth factor; Extracellular matrix; Glutamic acid; Host specificity; Laminin; Matrix protein; PagN; Pathogenesis; Plasmids; Proteins; Residues; S. diarizonae; S. Typhi; S. Typhimurium; Salmonella; Salmonella enterica; Virulence; Virulence factors; United States > US; S. diarizonae; Salmonella; adhesin; S. Typhi; S. Typhimurium; invasin; PagN; allelic variants; alleles

While advances in genomic sequencing have highlighted significant strain variability between and within serovars, only a few protein variants have been directly related to evolutionary adaptation for survival, such as host specificity or differential virulence. The current study investigated whether...