Flow Cytometric Analysis of Lymphocyte Subpopulations and Th1/Th2 Balance in Patients with Polymyositis and Dermatomyositis

• Published in: Internal Medicine Vol. 47; no. 18; pp. 1593 - 1599
• Main Authors: Sumida, Takayuki, Matsuda, Masayuki, Ishii, Wataru, Shimojima, Yasuhiro, Itoh, Susumu, Ikeda, Shu-ichi
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 01.01.2008
• Subjects: Adult; Aged; Aged, 80 and over; B-Lymphocytes - immunology; Biomarkers - blood; Case-Control Studies; Cohort Studies; Cytokines - blood; dermatomyositis; Dermatomyositis - blood; Dermatomyositis - immunology; Female; Flow Cytometry; Humans; Immunophenotyping; intracytoplasmic cytokine; Lymphocyte Subsets - classification; Lymphocyte Subsets - immunology; Male; Middle Aged; polymyositis; Th1 Cells - immunology; Th1/Th2 balance; Th2 Cells - immunology

Objective Polymyositis (PM) and dermatomyositis (DM) are idiopathic inflammatory myopathies; autoimmune mechanisms are thought to play an important role in their pathogenesis. We investigated the immunocytochemical characteristics and Th1/Th2 balance of peripheral blood lymphocytes in PM and DM usin...