Analysis of SARS-CoV-2 variant mutations reveals neutralization escape mechanisms and the ability to use ACE2 receptors from additional species

• Published in: Immunity (Cambridge, Mass.) Vol. 54; no. 7; pp. 1611 - 1621.e5
• Main Authors: Wang, Ruoke, Zhang, Qi, Ge, Jiwan, Ren, Wenlin, Zhang, Rui, Lan, Jun, Ju, Bin, Su, Bin, Yu, Fengting, Chen, Peng, Liao, Huiyu, Feng, Yingmei, Li, Xuemei, Shi, Xuanling, Zhang, Zheng, Zhang, Fujie, Ding, Qiang, Zhang, Tong, Wang, Xinquan, Zhang, Linqi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 13.07.2021; Elsevier Limited
• Subjects: ACE2; Angiotensin-converting enzyme 2; Angiotensin-Converting Enzyme 2 - metabolism; Animals; Antibodies; Antibodies, Monoclonal - chemistry; Antibodies, Monoclonal - immunology; Antibodies, Neutralizing - chemistry; Antibodies, Neutralizing - immunology; antibody; Antigenic Variation - genetics; Antigens; Coronaviruses; COVID-19; COVID-19 - immunology; COVID-19 - virology; COVID-19 vaccines; Crystal structure; Disease transmission; Domains; Host range; Host Specificity; Humans; immune escape; Immune Evasion - genetics; Immunotherapy; Infections; Mice; Mink; Monoclonal antibodies; Mutation; Neutralization; Pandemics; Protein Binding; Proteins; Receptors; RNA polymerase; SARS-CoV-2; SARS-CoV-2 - genetics; SARS-CoV-2 - immunology; SARS-CoV-2 - physiology; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - chemistry; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - immunology; Spike Glycoprotein, Coronavirus - metabolism; Structural analysis; Vaccines; variant of concern; Viral diseases; Virus Internalization; United Kingdom > UK; England; variant of concern; SARS-CoV-2; immune escape; antibody; neutralization

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants continue to emerge during the global pandemic and may facilitate escape from current antibody therapies and vaccine protection. Here we showed that the South African variant B.1.351 was the most resistant to current monoclonal ant...