Quantification of GC-biased gene conversion in the human genome

• Published in: Genome research Vol. 25; no. 8; pp. 1215 - 1228
• Main Authors: Glémin, Sylvain, Arndt, Peter F., Messer, Philipp W., Petrov, Dmitri, Galtier, Nicolas, Duret, Laurent
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.08.2015
• Subjects: Base Composition; Biochemistry, Molecular Biology; Biodiversity; Continental Population Groups - genetics; CpG Islands; Gene Conversion; Gene Frequency; Genetics; Genome, Human; Genomics; Humans; Life Sciences; Method; Models, Genetic; Polymorphism, Genetic; Populations and Evolution; Systematics, Phylogenetics and taxonomy
• ISSN: 1088-9051; 1549-5469; 1549-5469
• DOI: 10.1101/gr.185488.114

Much evidence indicates that GC-biased gene conversion (gBGC) has a major impact on the evolution of mammalian genomes. However, a detailed quantification of the process is still lacking. The strength of gBGC can be measured from the analysis of derived allele frequency spectra (DAF), but this appro...