Ghrelin ameliorates A549 cell apoptosis caused by paraquat via p38-MAPK regulated mitochondrial apoptotic pathway

• Published in: Toxicology (Amsterdam) Vol. 426; p. 152267
• Main Authors: Cui, Shuqing, Nian, Qing, Chen, Gang, Wang, Xingyong, Zhang, Jinying, Qiu, Jianqing, Zhang, Zhiqiang
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.10.2019
• Subjects: A549 Cells; acetylcysteine; Acute lung injury; antioxidants; Apoptosis; Apoptosis - drug effects; Caspase 3 - biosynthesis; Caspase 3 - drug effects; caspase-3; Cell Survival - drug effects; cell viability; Emergency; epithelial cells; Ghrelin; Ghrelin - pharmacology; Herbicides - toxicity; Humans; lipid peroxidation; lungs; MAP Kinase Signaling System - drug effects; membrane potential; Membrane Potential, Mitochondrial - drug effects; mitochondria; Mitochondria - drug effects; mitochondrial membrane; mitogen-activated protein kinase; mortality; oxidative stress; Oxidative Stress - drug effects; p38 Mitogen-Activated Protein Kinases - drug effects; p38 Mitogen-Activated Protein Kinases - metabolism; p38-MAPK; Paraquat; Paraquat - antagonists & inhibitors; Paraquat - toxicity; phosphorylation; Reactive Oxygen Species - metabolism; small interfering RNA; Acute lung injury; Paraquat; p38-MAPK; Ghrelin; Apoptosis

[Display omitted] •Ghrelin alleviated paraquat-induced A549 cell apoptosis.•Ghrelin suppressed paraquat-caused ROS production and p38-MAPK activation.•Ghrelin inhibited ROS-dependent mitochondrial apoptosis. Paraquat has relatively strong detrimental effects on humans and animals and can cause acute...