Oncofetal long noncoding RNA PVT1 promotes proliferation and stem cell‐like property of hepatocellular carcinoma cells by stabilizing NOP2

• Published in: Hepatology (Baltimore, Md.) Vol. 60; no. 4; pp. 1278 - 1290
• Main Authors: Wang, Fang, Yuan, Ji‐Hang, Wang, Shao‐Bing, Yang, Fu, Yuan, Sheng‐Xian, Ye, Chen, Yang, Ning, Zhou, Wei‐Ping, Li, Wen‐Lin, Li, Wen, Sun, Shu‐Han
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc 01.10.2014
• Subjects: Animals; Carcinoma, Hepatocellular - mortality; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - physiopathology; Cell Cycle - physiology; Cell growth; Cell Proliferation - physiology; Disease Models, Animal; Female; Hepatology; Humans; In Vitro Techniques; Liver cancer; Liver Neoplasms - mortality; Liver Neoplasms - pathology; Liver Neoplasms - physiopathology; Male; Mice; Middle Aged; Neoplastic Stem Cells - physiology; Nuclear Proteins - physiology; Phenotype; Prognosis; Proteins; RNA, Long Noncoding - physiology; Rodents; Signal Transduction - physiology; Stem cells; Transforming Growth Factor beta1 - physiology; tRNA Methyltransferases - physiology

Many protein‐coding oncofetal genes are highly expressed in murine and human fetal liver and silenced in adult liver. The protein products of these hepatic oncofetal genes have been used as clinical markers for the recurrence of hepatocellular carcinoma (HCC) and as therapeutic targets for HCC. Here...