Interleukin‐34 promotes tumor progression and metastatic process in osteosarcoma through induction of angiogenesis and macrophage recruitment

• Published in: International journal of cancer Vol. 137; no. 1; pp. 73 - 85
• Main Authors: Ségaliny, Aude I., Mohamadi, Amel, Dizier, Blandine, Lokajczyk, Anna, Brion, Régis, Lanel, Rachel, Amiaud, Jérôme, Charrier, Céline, Boisson‐Vidal, Catherine, Heymann, Dominique
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.07.2015
• Subjects: Angiogenesis; Animals; Bone cancer; Bone Neoplasms - blood supply; Bone Neoplasms - metabolism; Bone Neoplasms - pathology; Cancer; cell adhesion; Cell adhesion & migration; Cell growth; Cell Proliferation - drug effects; Cells, Cultured; Cytokines; endothelial cells; Gene Expression Regulation, Neoplastic; Human Umbilical Vein Endothelial Cells; Humans; In Vitro Techniques; Interleukin-1beta - metabolism; Interleukins - metabolism; Interleukins - pharmacology; interleukin‐34; Lung Neoplasms - blood supply; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Macrophages - metabolism; Medical research; Metastasis; Mice; M‐CSF; Neoplasm Transplantation; Neovascularization, Pathologic - metabolism; Oncology; osteosarcoma; Osteosarcoma - blood supply; Osteosarcoma - metabolism; Osteosarcoma - pathology; Recruitment; Tumor Necrosis Factor-alpha - metabolism; tumor‐associated macrophages; endothelial cells; M-CSF; angiogenesis; cell adhesion; osteosarcoma; interleukin-34; tumor-associated macrophages

Interleukin‐34 (IL‐34) was recently characterized as the M‐CSF “twin” cytokine, regulating the proliferation/differentiation/survival of myeloid cells. The implication of M‐CSF in oncology was initially suspected by the reduced metastatic dissemination in knock‐out mice, due to angiogenesis impairme...