JNK supports survival in melanoma cells by controlling cell cycle arrest and apoptosis

• Published in: Pigment cell and melanoma research Vol. 21; no. 4; pp. 429 - 438
• Main Authors: Alexaki, Vasileia-Ismini, Javelaud, Delphine, Mauviel, Alain
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.08.2008
• Subjects: Animals; Anthracenes - pharmacology; apoptosis; Apoptosis - drug effects; Apoptosis - physiology; cell cycle; Cell Cycle - drug effects; Cell Cycle - physiology; Cell Proliferation - drug effects; Cell Survival - drug effects; Cell Survival - physiology; growth arrest; Humans; JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors; JNK Mitogen-Activated Protein Kinases - physiology; JNK1; JNK2; melanoma; Melanoma - pathology; Mice; Mice, Nude; Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors; Mitogen-Activated Protein Kinase 8 - metabolism; Mitogen-Activated Protein Kinase 8 - physiology; Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors; Mitogen-Activated Protein Kinase 9 - metabolism; Mitogen-Activated Protein Kinase 9 - physiology; p21; p53; RNA, Small Interfering - pharmacology; Tumor Cells, Cultured

Summary JNK1/2 proteins belong to the family of stress‐activated protein kinases. They play a complex role in growth regulation, inducing either cell death or growth support. In this report, we provide evidence that, in human melanoma cells, JNK inhibition with the small molecule inhibitor SP600125...