Plasma cholesteryl ester transfer protein is predominantly derived from Kupffer cells

• Published in: Hepatology (Baltimore, Md.) Vol. 62; no. 6; pp. 1710 - 1722
• Main Authors: Wang, Yanan, van der Tuin, Sam, Tjeerdema, Nathanja, van Dam, Andrea D., Rensen, Sander S., Hendrikx, Tim, Berbée, Jimmy F.P., Atanasovska, Biljana, Fu, Jingyuan, Hoekstra, Menno, Bekkering, Siroon, Riksen, Niels P., Buurman, Wim A., Greve, Jan Willem, Hofker, Marten H., Shiri‐Sverdlov, Ronit, Meijer, Onno C., Smit, Johannes W.A., Havekes, Louis M., van Dijk, Ko Willems, Rensen, Patrick C.N.
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc 01.12.2015
• Subjects: Adult; Aged; Animals; Cholesterol Ester Transfer Proteins - metabolism; Female; Hepatology; Humans; Kupffer Cells - metabolism; Male; Mice; Mice, Transgenic; Middle Aged

The role of Kupffer cells (KCs) in the pathophysiology of the liver has been firmly established. Nevertheless, KCs have been underexplored as a target for diagnosis and treatment of liver diseases owing to the lack of noninvasive diagnostic tests. We addressed the hypothesis that cholesteryl ester t...