A conserved morphogenetic mechanism for epidermal ensheathment of nociceptive sensory neurites

• Published in: eLife Vol. 8
• Main Authors: Jiang, Nan, Rasmussen, Jeffrey P, Clanton, Joshua A, Rosenberg, Marci F, Luedke, Kory P, Cronan, Mark R, Parker, Edward D, Kim, Hyeon-Jin, Vaughan, Joshua C, Sagasti, Alvaro, Parrish, Jay Z
• Format: Journal Article
• Language: English
• Published: England eLife Science Publications, Ltd 11.03.2019; eLife Sciences Publications Ltd; eLife Sciences Publications, Ltd
• Subjects: Actin; Animals; Axonogenesis; Cell membranes; Chronic pain; Drosophila; ensheathment; Epidermal Cells - cytology; Epidermal Cells - physiology; epidermis; Epidermis - anatomy & histology; Epidermis - growth & development; Epithelial cells; Fruit flies (Tephritidae); Insects; Invertebrates; Machinery; Microscopy; Morphogenesis; Muscle proteins; Neural circuitry; Neurons; Neuroscience; nociception; Nociceptors; Nociceptors - cytology; Nociceptors - physiology; Observations; Olfaction; Pain management; Pain perception; Phosphatidylinositol 4,5-diphosphate; Phospholipids; Physiological aspects; Proteins; Sensory neurons; Sheaths; Skin; somatosensory neuron; Zebrafish; United States; Drosophila; neuroscience; nociception; ensheathment; zebrafish; D. melanogaster; epidermis; somatosensory neuron

Interactions between epithelial cells and neurons influence a range of sensory modalities including taste, touch, and smell. Vertebrate and invertebrate epidermal cells ensheath peripheral arbors of somatosensory neurons, including nociceptors, yet the developmental origins and functional roles of t...