A conserved morphogenetic mechanism for epidermal ensheathment of nociceptive sensory neurites

Interactions between epithelial cells and neurons influence a range of sensory modalities including taste, touch, and smell. Vertebrate and invertebrate epidermal cells ensheath peripheral arbors of somatosensory neurons, including nociceptors, yet the developmental origins and functional roles of t...

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Published ineLife Vol. 8
Main Authors Jiang, Nan, Rasmussen, Jeffrey P, Clanton, Joshua A, Rosenberg, Marci F, Luedke, Kory P, Cronan, Mark R, Parker, Edward D, Kim, Hyeon-Jin, Vaughan, Joshua C, Sagasti, Alvaro, Parrish, Jay Z
Format Journal Article
LanguageEnglish
Published England eLife Science Publications, Ltd 11.03.2019
eLife Sciences Publications Ltd
eLife Sciences Publications, Ltd
Subjects
Actin
Animals
Axonogenesis
Cell membranes
Chronic pain
Drosophila
ensheathment
Epidermal Cells - cytology
Epidermal Cells - physiology
epidermis
Epidermis - anatomy & histology
Epidermis - growth & development
Epithelial cells
Fruit flies (Tephritidae)
Insects
Invertebrates
Machinery
Microscopy
Morphogenesis
Muscle proteins
Neural circuitry
Neurons
Neuroscience
nociception
Nociceptors
Nociceptors - cytology
Nociceptors - physiology
Observations
Olfaction
Pain management
Pain perception
Phosphatidylinositol 4,5-diphosphate
Phospholipids
Physiological aspects
Proteins
Sensory neurons
Sheaths
Skin
somatosensory neuron
Zebrafish
United States
Drosophila
neuroscience
nociception
ensheathment
zebrafish
D. melanogaster
epidermis
somatosensory neuron
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Abstract Interactions between epithelial cells and neurons influence a range of sensory modalities including taste, touch, and smell. Vertebrate and invertebrate epidermal cells ensheath peripheral arbors of somatosensory neurons, including nociceptors, yet the developmental origins and functional roles of this ensheathment are largely unknown. Here, we describe an evolutionarily conserved morphogenetic mechanism for epidermal ensheathment of somatosensory neurites. We found that somatosensory neurons in and zebrafish induce formation of epidermal sheaths, which wrap neurites of different types of neurons to different extents. Neurites induce formation of plasma membrane phosphatidylinositol 4,5-bisphosphate microdomains at nascent sheaths, followed by a filamentous actin network, and recruitment of junctional proteins that likely form autotypic junctions to seal sheaths. Finally, blocking epidermal sheath formation destabilized dendrite branches and reduced nociceptive sensitivity in . Epidermal somatosensory neurite ensheathment is thus a deeply conserved cellular process that contributes to the morphogenesis and function of nociceptive sensory neurons.
AbstractList Interactions between epithelial cells and neurons influence a range of sensory modalities including taste, touch, and smell. Vertebrate and invertebrate epidermal cells ensheath peripheral arbors of somatosensory neurons, including nociceptors, yet the developmental origins and functional roles of this ensheathment are largely unknown. Here, we describe an evolutionarily conserved morphogenetic mechanism for epidermal ensheathment of somatosensory neurites. We found that somatosensory neurons in Drosophila and zebrafish induce formation of epidermal sheaths, which wrap neurites of different types of neurons to different extents. Neurites induce formation of plasma membrane phosphatidylinositol 4,5-bisphosphate microdomains at nascent sheaths, followed by a filamentous actin network, and recruitment of junctional proteins that likely form autotypic junctions to seal sheaths. Finally, blocking epidermal sheath formation destabilized dendrite branches and reduced nociceptive sensitivity in Drosophila. Epidermal somatosensory neurite ensheathment is thus a deeply conserved cellular process that contributes to the morphogenesis and function of nociceptive sensory neurons.
Interactions between epithelial cells and neurons influence a range of sensory modalities including taste, touch, and smell. Vertebrate and invertebrate epidermal cells ensheath peripheral arbors of somatosensory neurons, including nociceptors, yet the developmental origins and functional roles of this ensheathment are largely unknown. Here, we describe an evolutionarily conserved morphogenetic mechanism for epidermal ensheathment of somatosensory neurites. We found that somatosensory neurons in Drosophila and zebrafish induce formation of epidermal sheaths, which wrap neurites of different types of neurons to different extents. Neurites induce formation of plasma membrane phosphatidylinositol 4,5-bisphosphate microdomains at nascent sheaths, followed by a filamentous actin network, and recruitment of junctional proteins that likely form autotypic junctions to seal sheaths. Finally, blocking epidermal sheath formation destabilized dendrite branches and reduced nociceptive sensitivity in Drosophila . Epidermal somatosensory neurite ensheathment is thus a deeply conserved cellular process that contributes to the morphogenesis and function of nociceptive sensory neurons. Humans and other animals perceive and interact with the outside world through their sensory nervous system. Nerve cells, acting as the body’s ‘telegraph wires’, convey signals from sensory organs – like the eyes – to the brain, which then processes this information and tells the body how to respond. There are different kinds of sensory nerve cells that carry different types of information, but they all associate closely with the tissues and organs they connect to the brain. Human skin contains sensory nerve cells, which underpin our senses of touch and pain. There is a highly specialized, complex connection between some of these nerve cells and cells in the skin: the skin cells wrap tightly around the nerve cells’ free ends, forming sheath-like structures. This ‘ensheathment’ process happens in a wide range of animals, including those with a backbone, like fish and humans, and those without, like insects. Ensheathment is thought to be important for the skin’s nerve cells to work properly. Yet it remains unclear how or when these connections first appear. Jiang et al. therefore wanted to determine the developmental origins of ensheathment and to find out if these were also similar in animals with and without backbones. Experiments using fruit fly and zebrafish embryos revealed that nerve cells, not skin cells, were responsible for forming and maintaining the sheaths. In embryos where groups of sensory nerve cells were selectively killed – either using a laser or by making the cells produce a toxin – ensheathment did not occur. Further studies, using a variety of microscopy techniques, revealed that the molecular machinery required to stabilize the sheaths was similar in both fish and flies, and therefore likely to be conserved across different groups of animals. Removing sheaths in fly embryos led to nerve cells becoming unstable; the animals were also less sensitive to touch. This confirmed that ensheathment was indeed necessary for sensory nerve cells to work properly. By revealing how ensheathment first emerges, these findings shed new light on how the sensory nervous system develops and how its activity is controlled. In humans, skin cells ensheath the nerve cells responsible for sensing pain. A better understanding of how ensheathments first arise could therefore lead to new avenues for treating chronic pain and related conditions.
Interactions between epithelial cells and neurons influence a range of sensory modalities including taste, touch, and smell. Vertebrate and invertebrate epidermal cells ensheath peripheral arbors of somatosensory neurons, including nociceptors, yet the developmental origins and functional roles of this ensheathment are largely unknown. Here, we describe an evolutionarily conserved morphogenetic mechanism for epidermal ensheathment of somatosensory neurites. We found that somatosensory neurons in Drosophila and zebrafish induce formation of epidermal sheaths, which wrap neurites of different types of neurons to different extents. Neurites induce formation of plasma membrane phosphatidylinositol 4,5-bisphosphate microdomains at nascent sheaths, followed by a filamentous actin network, and recruitment of junctional proteins that likely form autotypic junctions to seal sheaths. Finally, blocking epidermal sheath formation destabilized dendrite branches and reduced nociceptive sensitivity in Drosophila. Epidermal somatosensory neurite ensheathment is thus a deeply conserved cellular process that contributes to the morphogenesis and function of nociceptive sensory neurons. eLife digest Humans and other animals perceive and interact with the outside world through their sensory nervous system. Nerve cells, acting as the body's 'telegraph wires', convey signals from sensory organs -- like the eyes -- to the brain, which then processes this information and tells the body how to respond. There are different kinds of sensory nerve cells that carry different types of information, but they all associate closely with the tissues and organs they connect to the brain. Human skin contains sensory nerve cells, which underpin our senses of touch and pain. There is a highly specialized, complex connection between some of these nerve cells and cells in the skin: the skin cells wrap tightly around the nerve cells' free ends, forming sheath-like structures. This 'ensheathment' process happens in a wide range of animals, including those with a backbone, like fish and humans, and those without, like insects. Ensheathment is thought to be important for the skin's nerve cells to work properly. Yet it remains unclear how or when these connections first appear. Jiang et al. therefore wanted to determine the developmental origins of ensheathment and to find out if these were also similar in animals with and without backbones. Experiments using fruit fly and zebrafish embryos revealed that nerve cells, not skin cells, were responsible for forming and maintaining the sheaths. In embryos where groups of sensory nerve cells were selectively killed -- either using a laser or by making the cells produce a toxin -- ensheathment did not occur. Further studies, using a variety of microscopy techniques, revealed that the molecular machinery required to stabilize the sheaths was similar in both fish and flies, and therefore likely to be conserved across different groups of animals. Removing sheaths in fly embryos led to nerve cells becoming unstable; the animals were also less sensitive to touch. This confirmed that ensheathment was indeed necessary for sensory nerve cells to work properly. By revealing how ensheathment first emerges, these findings shed new light on how the sensory nervous system develops and how its activity is controlled. In humans, skin cells ensheath the nerve cells responsible for sensing pain. A better understanding of how ensheathments first arise could therefore lead to new avenues for treating chronic pain and related conditions.
Interactions between epithelial cells and neurons influence a range of sensory modalities including taste, touch, and smell. Vertebrate and invertebrate epidermal cells ensheath peripheral arbors of somatosensory neurons, including nociceptors, yet the developmental origins and functional roles of this ensheathment are largely unknown. Here, we describe an evolutionarily conserved morphogenetic mechanism for epidermal ensheathment of somatosensory neurites. We found that somatosensory neurons in and zebrafish induce formation of epidermal sheaths, which wrap neurites of different types of neurons to different extents. Neurites induce formation of plasma membrane phosphatidylinositol 4,5-bisphosphate microdomains at nascent sheaths, followed by a filamentous actin network, and recruitment of junctional proteins that likely form autotypic junctions to seal sheaths. Finally, blocking epidermal sheath formation destabilized dendrite branches and reduced nociceptive sensitivity in . Epidermal somatosensory neurite ensheathment is thus a deeply conserved cellular process that contributes to the morphogenesis and function of nociceptive sensory neurons.
Interactions between epithelial cells and neurons influence a range of sensory modalities including taste, touch, and smell. Vertebrate and invertebrate epidermal cells ensheath peripheral arbors of somatosensory neurons, including nociceptors, yet the developmental origins and functional roles of this ensheathment are largely unknown. Here, we describe an evolutionarily conserved morphogenetic mechanism for epidermal ensheathment of somatosensory neurites. We found that somatosensory neurons in Drosophila and zebrafish induce formation of epidermal sheaths, which wrap neurites of different types of neurons to different extents. Neurites induce formation of plasma membrane phosphatidylinositol 4,5-bisphosphate microdomains at nascent sheaths, followed by a filamentous actin network, and recruitment of junctional proteins that likely form autotypic junctions to seal sheaths. Finally, blocking epidermal sheath formation destabilized dendrite branches and reduced nociceptive sensitivity in Drosophila. Epidermal somatosensory neurite ensheathment is thus a deeply conserved cellular process that contributes to the morphogenesis and function of nociceptive sensory neurons. Humans and other animals perceive and interact with the outside world through their sensory nervous system. Nerve cells, acting as the body’s ‘telegraph wires’, convey signals from sensory organs – like the eyes – to the brain, which then processes this information and tells the body how to respond. There are different kinds of sensory nerve cells that carry different types of information, but they all associate closely with the tissues and organs they connect to the brain. Human skin contains sensory nerve cells, which underpin our senses of touch and pain. There is a highly specialized, complex connection between some of these nerve cells and cells in the skin: the skin cells wrap tightly around the nerve cells’ free ends, forming sheath-like structures. This ‘ensheathment’ process happens in a wide range of animals, including those with a backbone, like fish and humans, and those without, like insects. Ensheathment is thought to be important for the skin’s nerve cells to work properly. Yet it remains unclear how or when these connections first appear. Jiang et al. therefore wanted to determine the developmental origins of ensheathment and to find out if these were also similar in animals with and without backbones. Experiments using fruit fly and zebrafish embryos revealed that nerve cells, not skin cells, were responsible for forming and maintaining the sheaths. In embryos where groups of sensory nerve cells were selectively killed – either using a laser or by making the cells produce a toxin – ensheathment did not occur. Further studies, using a variety of microscopy techniques, revealed that the molecular machinery required to stabilize the sheaths was similar in both fish and flies, and therefore likely to be conserved across different groups of animals. Removing sheaths in fly embryos led to nerve cells becoming unstable; the animals were also less sensitive to touch. This confirmed that ensheathment was indeed necessary for sensory nerve cells to work properly. By revealing how ensheathment first emerges, these findings shed new light on how the sensory nervous system develops and how its activity is controlled. In humans, skin cells ensheath the nerve cells responsible for sensing pain. A better understanding of how ensheathments first arise could therefore lead to new avenues for treating chronic pain and related conditions.
Audience Academic
Author Luedke, Kory P
Rasmussen, Jeffrey P
Parker, Edward D
Rosenberg, Marci F
Jiang, Nan
Clanton, Joshua A
Cronan, Mark R
Parrish, Jay Z
Vaughan, Joshua C
Kim, Hyeon-Jin
Sagasti, Alvaro
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/30855229$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1016/j.neuron.2013.11.021
10.1016/j.neuron.2009.06.017
10.1038/nature13251
10.1101/gad.174037.111
10.1016/j.devcel.2015.03.010
10.1179/1743132814Y.0000000377
10.1016/j.cub.2009.10.051
10.1016/0012-1606(81)90459-0
10.1101/cshperspect.a013656
10.1212/WNL.0b013e31821e553a
10.1016/j.cell.2013.08.059
10.1371/journal.pbio.0020329
10.1523/JNEUROSCI.3613-14.2015
10.1371/journal.pone.0053963
10.1091/mbc.12.9.2578
10.1021/bi060015v
10.1038/nmeth.2019
10.1242/dev.129.11.2639
10.1113/jphysiol.1966.sp007827
10.1091/mbc.E17-10-0583
10.1111/j.1346-8138.2001.tb00091.x
10.1111/nyas.12057
10.1091/mbc.e06-12-1159
10.7554/eLife.09674
10.1038/nature01082
10.3390/ijms18030634
10.1126/science.1095862
10.1074/jbc.M116.716464
10.1002/dvdy.21343
10.1523/JNEUROSCI.5951-08.2009
10.1534/genetics.110.119917
10.1038/nature12776
10.1111/j.1469-7998.1998.tb00158.x
10.7554/eLife.31684
10.1083/jcb.140.6.1463
10.1126/science.1073140
10.1016/S0092-8674(00)81540-8
10.1016/j.neuron.2011.10.033
10.1016/j.ydbio.2007.11.028
10.1016/j.cub.2005.03.048
10.1083/jcb.200412162
10.1038/nature04398
10.1242/dev.091876
10.1093/brain/awt053
10.1016/j.cub.2009.12.057
10.1242/jcs.180364
10.1073/pnas.1423357112
10.1016/j.devcel.2018.06.019
10.1002/glia.22625
10.1371/journal.pone.0185543
10.1016/j.celrep.2014.10.034
10.1523/JNEUROSCI.0022-14.2014
10.1146/annurev.physiol.65.092101.142517
10.1016/S0006-3495(04)74278-2
10.1523/JNEUROSCI.23-09-03752.2003
10.1038/nrm1910
10.1523/JNEUROSCI.3342-12.2013
10.1097/j.pain.0000000000000092
10.1242/dev.057521
10.1016/S0960-9822(03)00207-0
10.1038/nature13250
10.1016/j.celrep.2017.09.001
10.1042/bj20031089
10.1007/s00018-010-0432-5
10.1016/j.neuron.2011.10.036
10.1006/dbio.2002.0820
10.1002/bies.201200171
10.1111/1523-1747.ep12550322
10.1083/jcb.26.1.79
10.1038/nn.3881
10.1126/science.1254229
10.1016/j.neuron.2012.01.028
10.1016/S0960-9822(06)00262-4
10.1016/j.ydbio.2011.01.002
10.1083/jcb.151.7.1353
10.1093/bioinformatics/btr390
10.1038/nmeth.1328
10.1242/dev.107573
10.1002/cne.22791
10.1091/mbc.e11-05-0449
10.1016/S0960-9822(03)00596-7
10.1083/jcb.143.2.501
10.1073/pnas.0700895104
10.1016/j.cell.2013.08.058
10.1038/sj.bjp.0701148
10.1016/j.neuron.2009.08.006
10.1038/nn1139
10.1074/jbc.271.42.26187
10.1016/S0092-8674(00)81560-3
10.1038/nn1692
10.1038/nprot.2011.416
10.3791/1129
10.1038/s41592-018-0215-8
10.1083/jcb.201212095
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Keywords Drosophila
neuroscience
nociception
ensheathment
zebrafish
D. melanogaster
epidermis
somatosensory neuron
Language English
License 2019, Jiang et al.
http://creativecommons.org/licenses/by/4.0
This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
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content type line 23
Department of Biology, University of Washington, Seattle, United States.
ORCID 0000-0002-6550-8935
0000-0002-6823-0692
0000-0002-0656-9148
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References Kim (bib40) 2012; 73
Munger (bib55) 1965; 26
Risse (bib71) 2013; 8
O'Brien (bib59) 2009
Trinh (bib81) 2011; 25
Moehring (bib54) 2018; 7
O'Brien (bib58) 2009; 19
Gambhir (bib26) 2004; 86
Longair (bib48) 2011; 27
Baumbauer (bib5) 2015; 4
Michailov (bib52) 2004; 304
Honda (bib35) 1999; 99
Branson (bib8) 2009; 6
Sagasti (bib72) 2005; 15
Rasmussen (bib69) 2018; 46
Sun (bib78) 2013; 35
Suster (bib79) 2011; 6
Schindelin (bib74) 2012; 9
Kwan (bib42) 2007; 236
Chen (bib12) 2016; 291
Bidaux (bib6) 2015; 112
Whitear (bib88) 1998; 246
Glaser (bib28) 1996; 271
Liang (bib44) 2015; 33
Akitake (bib2) 2011; 352
Cornell (bib15) 2002; 129
Raucher (bib70) 2000; 100
McLaughlin (bib51) 2005; 438
Nguyen (bib57) 2017; 12
Han (bib32) 2014; 81
Sugimura (bib77) 2003; 23
Faroni (bib25) 2014; 62
Chen (bib13) 2014; 34
Kawakami (bib39) 2001; 28
Helker (bib34) 2013; 140
Weis (bib87) 2011; 76
Chung (bib14) 2013; 504
Zimmerman (bib95) 2014; 346
Woolf (bib90) 1997; 121
Verstreken (bib85) 2009; 63
Ainsley (bib1) 2003; 13
Owens (bib62) 2014; 4
Jiang (bib36) 2014; 141
Liu (bib46) 2014; 36
Maksimovic (bib50) 2014; 509
Xiong (bib91) 2012; 23
De Craene (bib19) 2017; 18
Xu (bib92) 2006; 9
Cronan (bib16) 2018; 15
Tenenbaum (bib80) 2017; 20
Várnai (bib84) 1998; 143
Salzberg (bib73) 2013; 155
Yin (bib93) 2003; 65
Koizumi (bib41) 2004; 380
Mihara (bib53) 1979; 73
Kachur (bib38) 2008; 314
Damke (bib18) 2001; 12
Han (bib31) 2012; 73
Andermann (bib4) 2002; 251
Cauna (bib9) 1973; 115
Denk (bib20) 2004; 2
Orita (bib61) 2013; 33
Ling (bib45) 2002; 420
Maksimovic (bib49) 2013; 1279
Üçeyler (bib82) 2013; 136
Zhong (bib94) 2010; 20
D'Souza-Schorey (bib17) 2006; 7
Doherty (bib21) 2009; 29
Chen (bib11) 2003; 6
O'Brien (bib60) 2012; 520
Myat (bib56) 1997; 7
Woo (bib89) 2014; 509
Ellis (bib24) 2013; 200
Grueber (bib30) 2003; 13
Botelho (bib7) 2000; 151
Rasmussen (bib68) 2015; 35
Jiang (bib37) 2018; 29
Scott (bib75) 2005; 169
Raphael (bib67) 2010; 137
Ward (bib86) 1998; 140
El Sayegh (bib23) 2007; 18
Dong (bib22) 2013; 155
Gorczyca (bib29) 2014; 9
Garrett (bib27) 2012; 74
Hardie (bib33) 2015; 128
Pfeiffer (bib66) 2010; 186
Parrish (bib64) 2009; 63
Peier (bib65) 2002; 296
Song (bib76) 2007; 104
Chalfie (bib10) 1981; 82
Kwiatkowska (bib43) 2010; 67
Pang (bib63) 2015; 156
Usoskin (bib83) 2015; 18
An (bib3) 2006; 45
Loewenstein (bib47) 1966; 182
References_xml – volume: 81
  start-page: 544
  year: 2014
  ident: bib32
  article-title: Epidermal cells are the primary phagocytes in the fragmentation and clearance of degenerating dendrites in Drosophila
  publication-title: Neuron
  doi: 10.1016/j.neuron.2013.11.021
  contributor:
    fullname: Han
– volume: 63
  start-page: 203
  year: 2009
  ident: bib85
  article-title: Tweek, an evolutionarily conserved protein, is required for synaptic vesicle recycling
  publication-title: Neuron
  doi: 10.1016/j.neuron.2009.06.017
  contributor:
    fullname: Verstreken
– volume: 509
  start-page: 622
  year: 2014
  ident: bib89
  article-title: Piezo2 is required for Merkel-cell mechanotransduction
  publication-title: Nature
  doi: 10.1038/nature13251
  contributor:
    fullname: Woo
– volume: 25
  start-page: 2306
  year: 2011
  ident: bib81
  article-title: A versatile gene trap to visualize and interrogate the function of the vertebrate proteome
  publication-title: Genes & Development
  doi: 10.1101/gad.174037.111
  contributor:
    fullname: Trinh
– volume: 33
  start-page: 388
  year: 2015
  ident: bib44
  article-title: Sarcomeres pattern proprioceptive sensory dendritic endings through UNC-52/Perlecan in C. elegans
  publication-title: Developmental Cell
  doi: 10.1016/j.devcel.2015.03.010
  contributor:
    fullname: Liang
– volume: 36
  start-page: 911
  year: 2014
  ident: bib46
  article-title: Intraepidermal nerve fiber density of healthy human
  publication-title: Neurological Research
  doi: 10.1179/1743132814Y.0000000377
  contributor:
    fullname: Liu
– volume: 19
  start-page: 2086
  year: 2009
  ident: bib58
  article-title: Developmentally regulated impediments to skin reinnervation by injured peripheral sensory axon terminals
  publication-title: Current Biology
  doi: 10.1016/j.cub.2009.10.051
  contributor:
    fullname: O'Brien
– volume: 82
  start-page: 358
  year: 1981
  ident: bib10
  article-title: Developmental genetics of the mechanosensory neurons of caenorhabditis elegans
  publication-title: Developmental Biology
  doi: 10.1016/0012-1606(81)90459-0
  contributor:
    fullname: Chalfie
– volume: 4
  year: 2014
  ident: bib62
  article-title: Diversification and specialization of touch receptors in skin
  publication-title: Cold Spring Harbor Perspectives in Medicine
  doi: 10.1101/cshperspect.a013656
  contributor:
    fullname: Owens
– volume: 76
  start-page: 2024
  year: 2011
  ident: bib87
  article-title: Small-fiber neuropathy in patients with ALS
  publication-title: Neurology
  doi: 10.1212/WNL.0b013e31821e553a
  contributor:
    fullname: Weis
– volume: 155
  start-page: 296
  year: 2013
  ident: bib22
  article-title: An extracellular adhesion molecule complex patterns dendritic branching and morphogenesis
  publication-title: Cell
  doi: 10.1016/j.cell.2013.08.059
  contributor:
    fullname: Dong
– volume: 2
  year: 2004
  ident: bib20
  article-title: Serial block-face scanning electron microscopy to reconstruct three-dimensional tissue nanostructure
  publication-title: PLOS Biology
  doi: 10.1371/journal.pbio.0020329
  contributor:
    fullname: Denk
– volume: 35
  start-page: 559
  year: 2015
  ident: bib68
  article-title: Vertebrate epidermal cells are broad-specificity phagocytes that clear sensory axon debris
  publication-title: Journal of Neuroscience
  doi: 10.1523/JNEUROSCI.3613-14.2015
  contributor:
    fullname: Rasmussen
– volume: 8
  year: 2013
  ident: bib71
  article-title: FIM, a novel FTIR-based imaging method for high throughput locomotion analysis
  publication-title: PLOS ONE
  doi: 10.1371/journal.pone.0053963
  contributor:
    fullname: Risse
– volume: 12
  start-page: 2578
  year: 2001
  ident: bib18
  article-title: Dynamin GTPase domain mutants block endocytic vesicle formation at morphologically distinct stages
  publication-title: Molecular Biology of the Cell
  doi: 10.1091/mbc.12.9.2578
  contributor:
    fullname: Damke
– volume: 45
  start-page: 5725
  year: 2006
  ident: bib3
  article-title: Phosphatidylinositol-4,5-biphosphate (PIP2) differentially regulates the interaction of human erythrocyte protein 4.1 (4.1R) with membrane proteins
  publication-title: Biochemistry
  doi: 10.1021/bi060015v
  contributor:
    fullname: An
– volume: 9
  start-page: 676
  year: 2012
  ident: bib74
  article-title: Fiji: an open-source platform for biological-image analysis
  publication-title: Nature Methods
  doi: 10.1038/nmeth.2019
  contributor:
    fullname: Schindelin
– volume: 129
  start-page: 2639
  year: 2002
  ident: bib15
  article-title: Delta/Notch signaling promotes formation of zebrafish neural crest by repressing neurogenin 1 function
  publication-title: Development
  doi: 10.1242/dev.129.11.2639
  contributor:
    fullname: Cornell
– volume: 182
  start-page: 346
  year: 1966
  ident: bib47
  article-title: Mechanical transmission in a pacinian corpuscle. an analysis and a theory
  publication-title: The Journal of Physiology
  doi: 10.1113/jphysiol.1966.sp007827
  contributor:
    fullname: Loewenstein
– volume: 29
  start-page: 1413
  year: 2018
  ident: bib37
  article-title: Superresolution imaging of Drosophila tissues using expansion microscopy
  publication-title: Molecular Biology of the Cell
  doi: 10.1091/mbc.E17-10-0583
  contributor:
    fullname: Jiang
– volume: 28
  start-page: 63
  year: 2001
  ident: bib39
  article-title: Distribution density of intraepidermal nerve fibers in normal human skin
  publication-title: The Journal of Dermatology
  doi: 10.1111/j.1346-8138.2001.tb00091.x
  contributor:
    fullname: Kawakami
– volume: 1279
  start-page: 13
  year: 2013
  ident: bib49
  article-title: Neurotransmitters and synaptic components in the merkel cell-neurite complex, a gentle-touch receptor
  publication-title: Annals of the New York Academy of Sciences
  doi: 10.1111/nyas.12057
  contributor:
    fullname: Maksimovic
– volume: 18
  start-page: 3026
  year: 2007
  ident: bib23
  article-title: Phosphatidylinositol-4,5 bisphosphate produced by PIP5KIgamma regulates gelsolin, actin assembly, and adhesion strength of N-cadherin junctions
  publication-title: Molecular Biology of the Cell
  doi: 10.1091/mbc.e06-12-1159
  contributor:
    fullname: El Sayegh
– volume: 4
  year: 2015
  ident: bib5
  article-title: Keratinocytes can modulate and directly initiate nociceptive responses
  publication-title: eLife
  doi: 10.7554/eLife.09674
  contributor:
    fullname: Baumbauer
– volume: 420
  start-page: 89
  year: 2002
  ident: bib45
  article-title: Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions
  publication-title: Nature
  doi: 10.1038/nature01082
  contributor:
    fullname: Ling
– volume: 18
  year: 2017
  ident: bib19
  article-title: Phosphoinositides, major actors in membrane trafficking and lipid signaling pathways
  publication-title: International Journal of Molecular Sciences
  doi: 10.3390/ijms18030634
  contributor:
    fullname: De Craene
– volume: 304
  start-page: 700
  year: 2004
  ident: bib52
  article-title: Axonal neuregulin-1 regulates myelin sheath thickness
  publication-title: Science
  doi: 10.1126/science.1095862
  contributor:
    fullname: Michailov
– volume: 291
  start-page: 10252
  year: 2016
  ident: bib12
  article-title: Transient receptor potential vanilloid 4 ion channel functions as a pruriceptor in epidermal keratinocytes to evoke histaminergic itch
  publication-title: Journal of Biological Chemistry
  doi: 10.1074/jbc.M116.716464
  contributor:
    fullname: Chen
– volume: 236
  start-page: 3088
  year: 2007
  ident: bib42
  article-title: The Tol2kit: a multisite gateway-based construction kit for Tol2 transposon transgenesis constructs
  publication-title: Developmental Dynamics
  doi: 10.1002/dvdy.21343
  contributor:
    fullname: Kwan
– volume: 29
  start-page: 4768
  year: 2009
  ident: bib21
  article-title: Ensheathing glia function as phagocytes in the adult Drosophila brain
  publication-title: Journal of Neuroscience
  doi: 10.1523/JNEUROSCI.5951-08.2009
  contributor:
    fullname: Doherty
– volume: 186
  start-page: 735
  year: 2010
  ident: bib66
  article-title: Refinement of tools for targeted gene expression in Drosophila
  publication-title: Genetics
  doi: 10.1534/genetics.110.119917
  contributor:
    fullname: Pfeiffer
– volume: 504
  start-page: 394
  year: 2013
  ident: bib14
  article-title: Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways
  publication-title: Nature
  doi: 10.1038/nature12776
  contributor:
    fullname: Chung
– volume: 246
  start-page: 275
  year: 1998
  ident: bib88
  article-title: Cellular diversity in the epidermis of raja clavata (Chondrichthyes)
  publication-title: Journal of Zoology
  doi: 10.1111/j.1469-7998.1998.tb00158.x
  contributor:
    fullname: Whitear
– volume: 7
  year: 2018
  ident: bib54
  article-title: Keratinocytes mediate innocuous and noxious touch via ATP-P2X4 signaling
  publication-title: eLife
  doi: 10.7554/eLife.31684
  contributor:
    fullname: Moehring
– volume: 140
  start-page: 1463
  year: 1998
  ident: bib86
  article-title: A conserved functional domain of Drosophila coracle is required for localization at the septate junction and has membrane-organizing activity
  publication-title: The Journal of Cell Biology
  doi: 10.1083/jcb.140.6.1463
  contributor:
    fullname: Ward
– volume: 296
  start-page: 2046
  year: 2002
  ident: bib65
  article-title: A heat-sensitive TRP channel expressed in keratinocytes
  publication-title: Science
  doi: 10.1126/science.1073140
  contributor:
    fullname: Peier
– volume: 99
  start-page: 521
  year: 1999
  ident: bib35
  article-title: Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)81540-8
  contributor:
    fullname: Honda
– volume: 73
  start-page: 79
  year: 2012
  ident: bib40
  article-title: Integrins establish dendrite-substrate relationships that promote dendritic self-avoidance and patterning in Drosophila sensory neurons
  publication-title: Neuron
  doi: 10.1016/j.neuron.2011.10.033
  contributor:
    fullname: Kim
– volume: 314
  start-page: 287
  year: 2008
  ident: bib38
  article-title: UNC-45 is required for NMY-2 contractile function in early embryonic polarity establishment and germline cellularization in C. elegans
  publication-title: Developmental Biology
  doi: 10.1016/j.ydbio.2007.11.028
  contributor:
    fullname: Kachur
– volume: 15
  start-page: 804
  year: 2005
  ident: bib72
  article-title: Repulsive interactions shape the morphologies and functional arrangement of zebrafish peripheral sensory arbors
  publication-title: Current Biology
  doi: 10.1016/j.cub.2005.03.048
  contributor:
    fullname: Sagasti
– volume: 169
  start-page: 139
  year: 2005
  ident: bib75
  article-title: Phosphatidylinositol-4,5-bisphosphate Hydrolysis directs actin remodeling during phagocytosis
  publication-title: The Journal of Cell Biology
  doi: 10.1083/jcb.200412162
  contributor:
    fullname: Scott
– volume: 438
  start-page: 605
  year: 2005
  ident: bib51
  article-title: Plasma membrane phosphoinositide organization by protein electrostatics
  publication-title: Nature
  doi: 10.1038/nature04398
  contributor:
    fullname: McLaughlin
– volume: 140
  start-page: 2776
  year: 2013
  ident: bib34
  article-title: The zebrafish common cardinal veins develop by a novel mechanism: lumen ensheathment
  publication-title: Development
  doi: 10.1242/dev.091876
  contributor:
    fullname: Helker
– volume: 136
  start-page: 1857
  year: 2013
  ident: bib82
  article-title: Small fibre pathology in patients with Fibromyalgia syndrome
  publication-title: Brain
  doi: 10.1093/brain/awt053
  contributor:
    fullname: Üçeyler
– volume: 20
  start-page: 429
  year: 2010
  ident: bib94
  article-title: Pickpocket is a DEG/ENaC protein required for mechanical nociception in Drosophila larvae
  publication-title: Current Biology
  doi: 10.1016/j.cub.2009.12.057
  contributor:
    fullname: Zhong
– volume: 128
  start-page: 4328
  year: 2015
  ident: bib33
  article-title: In vivo tracking of phosphoinositides in Drosophila photoreceptors
  publication-title: Journal of Cell Science
  doi: 10.1242/jcs.180364
  contributor:
    fullname: Hardie
– volume: 112
  start-page: E3345
  year: 2015
  ident: bib6
  article-title: Epidermal TRPM8 channel isoform controls the balance between keratinocyte proliferation and differentiation in a cold-dependent manner
  publication-title: PNAS
  doi: 10.1073/pnas.1423357112
  contributor:
    fullname: Bidaux
– volume: 46
  start-page: 344
  year: 2018
  ident: bib69
  article-title: Fish scales dictate the pattern of adult skin innervation and vascularization
  publication-title: Developmental Cell
  doi: 10.1016/j.devcel.2018.06.019
  contributor:
    fullname: Rasmussen
– volume: 62
  start-page: 548
  year: 2014
  ident: bib25
  article-title: Deletion of GABA-B receptor in schwann cells regulates remak bundles and small nociceptive C-fibers
  publication-title: Glia
  doi: 10.1002/glia.22625
  contributor:
    fullname: Faroni
– volume: 12
  year: 2017
  ident: bib57
  article-title: Diversity amongst trigeminal neurons revealed by high throughput single cell sequencing
  publication-title: PLOS ONE
  doi: 10.1371/journal.pone.0185543
  contributor:
    fullname: Nguyen
– volume: 9
  start-page: 1446
  year: 2014
  ident: bib29
  article-title: Identification of Ppk26, a DEG/ENaC channel functioning with Ppk1 in a mutually dependent manner to guide locomotion behavior in Drosophila
  publication-title: Cell Reports
  doi: 10.1016/j.celrep.2014.10.034
  contributor:
    fullname: Gorczyca
– volume: 34
  start-page: 6522
  year: 2014
  ident: bib13
  article-title: Modulation of C. elegans touch sensitivity is integrated at multiple levels
  publication-title: Journal of Neuroscience
  doi: 10.1523/JNEUROSCI.0022-14.2014
  contributor:
    fullname: Chen
– volume: 65
  start-page: 761
  year: 2003
  ident: bib93
  article-title: Phosphoinositide regulation of the actin cytoskeleton
  publication-title: Annual Review of Physiology
  doi: 10.1146/annurev.physiol.65.092101.142517
  contributor:
    fullname: Yin
– volume: 86
  start-page: 2188
  year: 2004
  ident: bib26
  article-title: Electrostatic sequestration of PIP2 on phospholipid membranes by basic/aromatic regions of proteins
  publication-title: Biophysical Journal
  doi: 10.1016/S0006-3495(04)74278-2
  contributor:
    fullname: Gambhir
– volume: 23
  start-page: 3752
  year: 2003
  ident: bib77
  article-title: Distinct developmental modes and lesion-induced reactions of dendrites of two classes of Drosophila sensory neurons
  publication-title: The Journal of Neuroscience
  doi: 10.1523/JNEUROSCI.23-09-03752.2003
  contributor:
    fullname: Sugimura
– volume: 7
  start-page: 347
  year: 2006
  ident: bib17
  article-title: ARF proteins: roles in membrane traffic and beyond
  publication-title: Nature Reviews Molecular Cell Biology
  doi: 10.1038/nrm1910
  contributor:
    fullname: D'Souza-Schorey
– volume: 33
  start-page: 5590
  year: 2013
  ident: bib61
  article-title: Schwann cell LRP1 regulates remak bundle ultrastructure and axonal interactions to prevent neuropathic pain
  publication-title: Journal of Neuroscience
  doi: 10.1523/JNEUROSCI.3342-12.2013
  contributor:
    fullname: Orita
– volume: 156
  start-page: 656
  year: 2015
  ident: bib63
  article-title: Selective keratinocyte stimulation is sufficient to evoke nociception in mice
  publication-title: Pain
  doi: 10.1097/j.pain.0000000000000092
  contributor:
    fullname: Pang
– volume: 137
  start-page: 3643
  year: 2010
  ident: bib67
  article-title: Schwann cells reposition a peripheral nerve to isolate it from postembryonic remodeling of its targets
  publication-title: Development
  doi: 10.1242/dev.057521
  contributor:
    fullname: Raphael
– volume: 13
  start-page: 618
  year: 2003
  ident: bib30
  article-title: Dendrites of distinct classes of Drosophila sensory neurons show different capacities for homotypic repulsion
  publication-title: Current Biology
  doi: 10.1016/S0960-9822(03)00207-0
  contributor:
    fullname: Grueber
– volume: 509
  start-page: 617
  year: 2014
  ident: bib50
  article-title: Epidermal merkel cells are mechanosensory cells that tune mammalian touch receptors
  publication-title: Nature
  doi: 10.1038/nature13250
  contributor:
    fullname: Maksimovic
– volume: 20
  start-page: 3043
  year: 2017
  ident: bib80
  article-title: Enclosure of dendrites by epidermal cells restricts branching and permits coordinated development of spatially overlapping sensory neurons
  publication-title: Cell Reports
  doi: 10.1016/j.celrep.2017.09.001
  contributor:
    fullname: Tenenbaum
– volume: 380
  start-page: 329
  year: 2004
  ident: bib41
  article-title: Ca2+ waves in keratinocytes are transmitted to sensory neurons: the involvement of extracellular ATP and P2Y2 receptor activation
  publication-title: Biochemical Journal
  doi: 10.1042/bj20031089
  contributor:
    fullname: Koizumi
– volume: 67
  start-page: 3927
  year: 2010
  ident: bib43
  article-title: One lipid, multiple functions: how various pools of PI(4,5)P(2) are created in the plasma membrane
  publication-title: Cellular and Molecular Life Sciences
  doi: 10.1007/s00018-010-0432-5
  contributor:
    fullname: Kwiatkowska
– volume: 73
  start-page: 64
  year: 2012
  ident: bib31
  article-title: Integrins regulate repulsion-mediated dendritic patterning of Drosophila sensory neurons by restricting dendrites in a 2D space
  publication-title: Neuron
  doi: 10.1016/j.neuron.2011.10.036
  contributor:
    fullname: Han
– volume: 251
  start-page: 45
  year: 2002
  ident: bib4
  article-title: Neurogenin1 defines zebrafish cranial sensory ganglia precursors
  publication-title: Developmental Biology
  doi: 10.1006/dbio.2002.0820
  contributor:
    fullname: Andermann
– volume: 35
  start-page: 513
  year: 2013
  ident: bib78
  article-title: Phosphatidylinositol 4,5-bisphosphate: targeted production and signaling
  publication-title: BioEssays
  doi: 10.1002/bies.201200171
  contributor:
    fullname: Sun
– volume: 73
  start-page: 325
  year: 1979
  ident: bib53
  article-title: The Specialized Junctions between Merkel Cell and Neurite: An Electron Microscopic Study
  publication-title: Journal of Investigative Dermatology
  doi: 10.1111/1523-1747.ep12550322
  contributor:
    fullname: Mihara
– volume: 26
  start-page: 79
  year: 1965
  ident: bib55
  article-title: The intraepidermal innervation of the snout skin of the opossum. A light and electron microscope study, with observations on the nature of Merkel's Tastzellen
  publication-title: The Journal of Cell Biology
  doi: 10.1083/jcb.26.1.79
  contributor:
    fullname: Munger
– volume: 18
  start-page: 145
  year: 2015
  ident: bib83
  article-title: Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing
  publication-title: Nature Neuroscience
  doi: 10.1038/nn.3881
  contributor:
    fullname: Usoskin
– volume: 346
  start-page: 950
  year: 2014
  ident: bib95
  article-title: The gentle touch receptors of mammalian skin
  publication-title: Science
  doi: 10.1126/science.1254229
  contributor:
    fullname: Zimmerman
– volume: 74
  start-page: 269
  year: 2012
  ident: bib27
  article-title: γ-protocadherins control cortical dendrite arborization by regulating the activity of a FAK/PKC/MARCKS signaling pathway
  publication-title: Neuron
  doi: 10.1016/j.neuron.2012.01.028
  contributor:
    fullname: Garrett
– volume: 7
  start-page: 611
  year: 1997
  ident: bib56
  article-title: MARCKS regulates membrane ruffling and cell spreading
  publication-title: Current Biology
  doi: 10.1016/S0960-9822(06)00262-4
  contributor:
    fullname: Myat
– volume: 352
  start-page: 191
  year: 2011
  ident: bib2
  article-title: Transgenerational analysis of transcriptional silencing in zebrafish
  publication-title: Developmental Biology
  doi: 10.1016/j.ydbio.2011.01.002
  contributor:
    fullname: Akitake
– volume: 151
  start-page: 1353
  year: 2000
  ident: bib7
  article-title: Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis
  publication-title: The Journal of Cell Biology
  doi: 10.1083/jcb.151.7.1353
  contributor:
    fullname: Botelho
– volume: 115
  start-page: 277
  year: 1973
  ident: bib9
  article-title: The free penicillate nerve endings of the human hairy skin
  publication-title: Journal of Anatomy
  contributor:
    fullname: Cauna
– volume: 27
  start-page: 2453
  year: 2011
  ident: bib48
  article-title: Simple neurite tracer: open source software for reconstruction, visualization and analysis of neuronal processes
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btr390
  contributor:
    fullname: Longair
– volume: 6
  start-page: 451
  year: 2009
  ident: bib8
  article-title: High-throughput ethomics in large groups of Drosophila
  publication-title: Nature Methods
  doi: 10.1038/nmeth.1328
  contributor:
    fullname: Branson
– volume: 141
  start-page: 2657
  year: 2014
  ident: bib36
  article-title: The microRNA bantam regulates a developmental transition in epithelial cells that restricts sensory dendrite growth
  publication-title: Development
  doi: 10.1242/dev.107573
  contributor:
    fullname: Jiang
– volume: 520
  start-page: 816
  year: 2012
  ident: bib60
  article-title: Coordinate development of skin cells and cutaneous sensory axons in zebrafish
  publication-title: The Journal of Comparative Neurology
  doi: 10.1002/cne.22791
  contributor:
    fullname: O'Brien
– volume: 23
  start-page: 87
  year: 2012
  ident: bib91
  article-title: An association between type iγ PI4P 5-kinase and Exo70 directs E-cadherin clustering and epithelial polarization
  publication-title: Molecular Biology of the Cell
  doi: 10.1091/mbc.e11-05-0449
  contributor:
    fullname: Xiong
– volume: 13
  start-page: 1557
  year: 2003
  ident: bib1
  article-title: Enhanced locomotion caused by loss of the Drosophila DEG/ENaC protein Pickpocket1
  publication-title: Current Biology
  doi: 10.1016/S0960-9822(03)00596-7
  contributor:
    fullname: Ainsley
– volume: 143
  start-page: 501
  year: 1998
  ident: bib84
  article-title: Visualization of phosphoinositides that bind pleckstrin homology domains: calcium- and agonist-induced dynamic changes and relationship to myo-[3H]inositol-labeled phosphoinositide pools
  publication-title: The Journal of Cell Biology
  doi: 10.1083/jcb.143.2.501
  contributor:
    fullname: Várnai
– volume: 104
  start-page: 5199
  year: 2007
  ident: bib76
  article-title: Peripheral multidendritic sensory neurons are necessary for rhythmic locomotion behavior in Drosophila larvae
  publication-title: PNAS
  doi: 10.1073/pnas.0700895104
  contributor:
    fullname: Song
– volume: 155
  start-page: 308
  year: 2013
  ident: bib73
  article-title: Skin-derived cues control arborization of sensory dendrites in caenorhabditis elegans
  publication-title: Cell
  doi: 10.1016/j.cell.2013.08.058
  contributor:
    fullname: Salzberg
– volume: 121
  start-page: 417
  year: 1997
  ident: bib90
  article-title: Cytokines, nerve growth factor and inflammatory hyperalgesia: the contribution of tumour necrosis factor alpha
  publication-title: British Journal of Pharmacology
  doi: 10.1038/sj.bjp.0701148
  contributor:
    fullname: Woolf
– volume: 63
  start-page: 788
  year: 2009
  ident: bib64
  article-title: The microRNA bantam functions in epithelial cells to regulate scaling growth of dendrite arbors in Drosophila sensory neurons
  publication-title: Neuron
  doi: 10.1016/j.neuron.2009.08.006
  contributor:
    fullname: Parrish
– volume: 6
  start-page: 1186
  year: 2003
  ident: bib11
  article-title: Disruption of ErbB receptor signaling in adult non-myelinating schwann cells causes progressive sensory loss
  publication-title: Nature Neuroscience
  doi: 10.1038/nn1139
  contributor:
    fullname: Chen
– volume: 271
  start-page: 26187
  year: 1996
  ident: bib28
  article-title: Myristoylated alanine-rich C kinase substrate (MARCKS) produces reversible inhibition of phospholipase C by sequestering phosphatidylinositol 4,5-bisphosphate in lateral domains
  publication-title: Journal of Biological Chemistry
  doi: 10.1074/jbc.271.42.26187
  contributor:
    fullname: Glaser
– volume: 100
  start-page: 221
  year: 2000
  ident: bib70
  article-title: Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)81560-3
  contributor:
    fullname: Raucher
– volume: 9
  start-page: 628
  year: 2006
  ident: bib92
  article-title: Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels
  publication-title: Nature Neuroscience
  doi: 10.1038/nn1692
  contributor:
    fullname: Xu
– volume: 6
  start-page: 1998
  year: 2011
  ident: bib79
  article-title: Transposon-mediated BAC transgenesis in zebrafish
  publication-title: Nature Protocols
  doi: 10.1038/nprot.2011.416
  contributor:
    fullname: Suster
– year: 2009
  ident: bib59
  article-title: Two-Photon axotomy and Time-Lapse confocal imaging in live zebrafish embryos
  publication-title: Journal of Visualized Experiments : JoVE
  doi: 10.3791/1129
  contributor:
    fullname: O'Brien
– volume: 15
  start-page: 1098
  year: 2018
  ident: bib16
  article-title: An explant technique for high-resolution imaging and manipulation of mycobacterial granulomas
  publication-title: Nature Methods
  doi: 10.1038/s41592-018-0215-8
  contributor:
    fullname: Cronan
– volume: 200
  start-page: 667
  year: 2013
  ident: bib24
  article-title: Notochord vacuoles are lysosome-related organelles that function in axis and spine morphogenesis
  publication-title: The Journal of Cell Biology
  doi: 10.1083/jcb.201212095
  contributor:
    fullname: Ellis
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Snippet Interactions between epithelial cells and neurons influence a range of sensory modalities including taste, touch, and smell. Vertebrate and invertebrate...
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SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
SubjectTerms Actin
Animals
Axonogenesis
Cell membranes
Chronic pain
Drosophila
ensheathment
Epidermal Cells - cytology
Epidermal Cells - physiology
epidermis
Epidermis - anatomy & histology
Epidermis - growth & development
Epithelial cells
Fruit flies (Tephritidae)
Insects
Invertebrates
Machinery
Microscopy
Morphogenesis
Muscle proteins
Neural circuitry
Neurons
Neuroscience
nociception
Nociceptors
Nociceptors - cytology
Nociceptors - physiology
Observations
Olfaction
Pain management
Pain perception
Phosphatidylinositol 4,5-diphosphate
Phospholipids
Physiological aspects
Proteins
Sensory neurons
Sheaths
Skin
somatosensory neuron
Zebrafish
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Title A conserved morphogenetic mechanism for epidermal ensheathment of nociceptive sensory neurites
URI https://www.ncbi.nlm.nih.gov/pubmed/30855229
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Volume 8
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