Near‐Infrared‐Responded High Sensitivity Nanoprobe for Steady and Visualized Detection of Albumin in Hepatic Organoids and Mouse Liver

Exploring the advanced techniques for protein detection facilitates cell fate investigation. However, it remains challenging to quantify and visualize the protein with one single probe. Here, a luminescent approach to detect hepatic cell fate marker albumin in vitro and living cell labeling with upc...

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Published inAdvanced science Vol. 9; no. 26; pp. e2202505 - n/a
Main Authors Liu, Guofeng, Wei, Jinsong, Li, Xiaoyu, Tian, Meng, Wang, Zhenxing, Shen, Congcong, Sun, Wan, Li, Chonghui, Li, Xuewen, Lv, Enguang, Tian, Shizheng, Wang, Jihua, Xu, Shicai, Zhao, Bing
Format Journal Article
LanguageEnglish
Published Germany John Wiley & Sons, Inc 01.09.2022
John Wiley and Sons Inc
Wiley
Subjects
Albumins
Animals
Antibodies
Biocompatibility
Biomarkers
hepatic organoids
Infrared Rays
Lasers
Ligands
Liver
living cell labeling
Mice
mouse liver
Nanoparticles
near‐infrared‐responded high sensitivity nanoprobe
Organoids
protein quantification and imaging
Proteins
Quantum dots
near-infrared-responded high sensitivity nanoprobe
mouse liver
living cell labeling
hepatic organoids
protein quantification and imaging
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Abstract Exploring the advanced techniques for protein detection facilitates cell fate investigation. However, it remains challenging to quantify and visualize the protein with one single probe. Here, a luminescent approach to detect hepatic cell fate marker albumin in vitro and living cell labeling with upconversion nanoparticles (UCNPs), which are conjugated with antibody (Ab) and rose bengal hexanoic acid (RBHA) is reported. To guarantee the detection quality and accuracy, an “OFF–ON” strategy is adopted: in the presence of albumin, the luminescence of nanoparticles remains suppressed owing to energy transfer to the quencher. Upon albumin binding to the antibody, the luminescence is recovered under near‐infrared light. In various bio‐samples, the UCNPs‐Ab‐RBHA (UCAR) nanoprobe can sense albumin with a broad detection range (5–315 ng mL−1). When applied to liver ductal organoid culture medium, the UCAR can monitor hepatocyte differentiation in real time by sensing the secreted albumin. Further, UCAR enables live imaging of cellular albumin in cells, organoids, and tissues. In a CCl4‐induced liver injury model, UCAR detects reduced albumin in liver tissue and serum. Thus, a biocompatible nanoprobe for both quantification and imaging of protein in complex biological environment with superior stability and high sensitivity is provided. Förster resonance energy transfer‐based UCNPs‐Ab‐RBHA (upconversion nanoparticles‐antibody‐rose bengal hexanoic acid, UCAR) nanoprobe adopts an “OFF–ON” strategy to detect target protein. Under near‐infrared light, UCAR nanoprobe enables protein quantification in vitro and target cell labeling in living cells, organoids, and mouse liver with superior stability and high sensitivity, showing great potential in protein/cell tracking in vivo and clinical diagnosis.
AbstractList Exploring the advanced techniques for protein detection facilitates cell fate investigation. However, it remains challenging to quantify and visualize the protein with one single probe. Here, a luminescent approach to detect hepatic cell fate marker albumin in vitro and living cell labeling with upconversion nanoparticles (UCNPs), which are conjugated with antibody (Ab) and rose bengal hexanoic acid (RBHA) is reported. To guarantee the detection quality and accuracy, an "OFF-ON" strategy is adopted: in the presence of albumin, the luminescence of nanoparticles remains suppressed owing to energy transfer to the quencher. Upon albumin binding to the antibody, the luminescence is recovered under near-infrared light. In various bio-samples, the UCNPs-Ab-RBHA (UCAR) nanoprobe can sense albumin with a broad detection range (5-315 ng mL ). When applied to liver ductal organoid culture medium, the UCAR can monitor hepatocyte differentiation in real time by sensing the secreted albumin. Further, UCAR enables live imaging of cellular albumin in cells, organoids, and tissues. In a CCl -induced liver injury model, UCAR detects reduced albumin in liver tissue and serum. Thus, a biocompatible nanoprobe for both quantification and imaging of protein in complex biological environment with superior stability and high sensitivity is provided.
Exploring the advanced techniques for protein detection facilitates cell fate investigation. However, it remains challenging to quantify and visualize the protein with one single probe. Here, a luminescent approach to detect hepatic cell fate marker albumin in vitro and living cell labeling with upconversion nanoparticles (UCNPs), which are conjugated with antibody (Ab) and rose bengal hexanoic acid (RBHA) is reported. To guarantee the detection quality and accuracy, an “OFF–ON” strategy is adopted: in the presence of albumin, the luminescence of nanoparticles remains suppressed owing to energy transfer to the quencher. Upon albumin binding to the antibody, the luminescence is recovered under near-infrared light. In various bio-samples, the UCNPs-Ab-RBHA (UCAR) nanoprobe can sense albumin with a broad detection range (5–315 ng mL−1). When applied to liver ductal organoid culture medium, the UCAR can monitor hepatocyte differentiation in real time by sensing the secreted albumin. Further, UCAR enables live imaging of cellular albumin in cells, organoids, and tissues. In a CCl4-induced liver injury model, UCAR detects reduced albumin in liver tissue and serum. Thus, a biocompatible nanoprobe for both quantification and imaging of protein in complex biological environment with superior stability and high sensitivity is provided.
Exploring the advanced techniques for protein detection facilitates cell fate investigation. However, it remains challenging to quantify and visualize the protein with one single probe. Here, a luminescent approach to detect hepatic cell fate marker albumin in vitro and living cell labeling with upconversion nanoparticles (UCNPs), which are conjugated with antibody (Ab) and rose bengal hexanoic acid (RBHA) is reported. To guarantee the detection quality and accuracy, an “OFF–ON” strategy is adopted: in the presence of albumin, the luminescence of nanoparticles remains suppressed owing to energy transfer to the quencher. Upon albumin binding to the antibody, the luminescence is recovered under near‐infrared light. In various bio‐samples, the UC NPs‐ A b‐ R BHA (UCAR) nanoprobe can sense albumin with a broad detection range (5–315 ng mL −1 ). When applied to liver ductal organoid culture medium, the UCAR can monitor hepatocyte differentiation in real time by sensing the secreted albumin. Further, UCAR enables live imaging of cellular albumin in cells, organoids, and tissues. In a CCl 4 ‐induced liver injury model, UCAR detects reduced albumin in liver tissue and serum. Thus, a biocompatible nanoprobe for both quantification and imaging of protein in complex biological environment with superior stability and high sensitivity is provided.
Exploring the advanced techniques for protein detection facilitates cell fate investigation. However, it remains challenging to quantify and visualize the protein with one single probe. Here, a luminescent approach to detect hepatic cell fate marker albumin in vitro and living cell labeling with upconversion nanoparticles (UCNPs), which are conjugated with antibody (Ab) and rose bengal hexanoic acid (RBHA) is reported. To guarantee the detection quality and accuracy, an "OFF-ON" strategy is adopted: in the presence of albumin, the luminescence of nanoparticles remains suppressed owing to energy transfer to the quencher. Upon albumin binding to the antibody, the luminescence is recovered under near-infrared light. In various bio-samples, the UCNPs-Ab-RBHA (UCAR) nanoprobe can sense albumin with a broad detection range (5-315 ng mL-1 ). When applied to liver ductal organoid culture medium, the UCAR can monitor hepatocyte differentiation in real time by sensing the secreted albumin. Further, UCAR enables live imaging of cellular albumin in cells, organoids, and tissues. In a CCl4 -induced liver injury model, UCAR detects reduced albumin in liver tissue and serum. Thus, a biocompatible nanoprobe for both quantification and imaging of protein in complex biological environment with superior stability and high sensitivity is provided.Exploring the advanced techniques for protein detection facilitates cell fate investigation. However, it remains challenging to quantify and visualize the protein with one single probe. Here, a luminescent approach to detect hepatic cell fate marker albumin in vitro and living cell labeling with upconversion nanoparticles (UCNPs), which are conjugated with antibody (Ab) and rose bengal hexanoic acid (RBHA) is reported. To guarantee the detection quality and accuracy, an "OFF-ON" strategy is adopted: in the presence of albumin, the luminescence of nanoparticles remains suppressed owing to energy transfer to the quencher. Upon albumin binding to the antibody, the luminescence is recovered under near-infrared light. In various bio-samples, the UCNPs-Ab-RBHA (UCAR) nanoprobe can sense albumin with a broad detection range (5-315 ng mL-1 ). When applied to liver ductal organoid culture medium, the UCAR can monitor hepatocyte differentiation in real time by sensing the secreted albumin. Further, UCAR enables live imaging of cellular albumin in cells, organoids, and tissues. In a CCl4 -induced liver injury model, UCAR detects reduced albumin in liver tissue and serum. Thus, a biocompatible nanoprobe for both quantification and imaging of protein in complex biological environment with superior stability and high sensitivity is provided.
Exploring the advanced techniques for protein detection facilitates cell fate investigation. However, it remains challenging to quantify and visualize the protein with one single probe. Here, a luminescent approach to detect hepatic cell fate marker albumin in vitro and living cell labeling with upconversion nanoparticles (UCNPs), which are conjugated with antibody (Ab) and rose bengal hexanoic acid (RBHA) is reported. To guarantee the detection quality and accuracy, an “OFF–ON” strategy is adopted: in the presence of albumin, the luminescence of nanoparticles remains suppressed owing to energy transfer to the quencher. Upon albumin binding to the antibody, the luminescence is recovered under near‐infrared light. In various bio‐samples, the UC NPs‐ A b‐ R BHA (UCAR) nanoprobe can sense albumin with a broad detection range (5–315 ng mL −1 ). When applied to liver ductal organoid culture medium, the UCAR can monitor hepatocyte differentiation in real time by sensing the secreted albumin. Further, UCAR enables live imaging of cellular albumin in cells, organoids, and tissues. In a CCl 4 ‐induced liver injury model, UCAR detects reduced albumin in liver tissue and serum. Thus, a biocompatible nanoprobe for both quantification and imaging of protein in complex biological environment with superior stability and high sensitivity is provided. Förster resonance energy transfer‐based UCNPs‐Ab‐RBHA (upconversion nanoparticles‐antibody‐rose bengal hexanoic acid, UCAR) nanoprobe adopts an “OFF–ON” strategy to detect target protein. Under near‐infrared light, UCAR nanoprobe enables protein quantification in vitro and target cell labeling in living cells, organoids, and mouse liver with superior stability and high sensitivity, showing great potential in protein/cell tracking in vivo and clinical diagnosis.
Abstract Exploring the advanced techniques for protein detection facilitates cell fate investigation. However, it remains challenging to quantify and visualize the protein with one single probe. Here, a luminescent approach to detect hepatic cell fate marker albumin in vitro and living cell labeling with upconversion nanoparticles (UCNPs), which are conjugated with antibody (Ab) and rose bengal hexanoic acid (RBHA) is reported. To guarantee the detection quality and accuracy, an “OFF–ON” strategy is adopted: in the presence of albumin, the luminescence of nanoparticles remains suppressed owing to energy transfer to the quencher. Upon albumin binding to the antibody, the luminescence is recovered under near‐infrared light. In various bio‐samples, the UCNPs‐Ab‐RBHA (UCAR) nanoprobe can sense albumin with a broad detection range (5–315 ng mL−1). When applied to liver ductal organoid culture medium, the UCAR can monitor hepatocyte differentiation in real time by sensing the secreted albumin. Further, UCAR enables live imaging of cellular albumin in cells, organoids, and tissues. In a CCl4‐induced liver injury model, UCAR detects reduced albumin in liver tissue and serum. Thus, a biocompatible nanoprobe for both quantification and imaging of protein in complex biological environment with superior stability and high sensitivity is provided.
Exploring the advanced techniques for protein detection facilitates cell fate investigation. However, it remains challenging to quantify and visualize the protein with one single probe. Here, a luminescent approach to detect hepatic cell fate marker albumin in vitro and living cell labeling with upconversion nanoparticles (UCNPs), which are conjugated with antibody (Ab) and rose bengal hexanoic acid (RBHA) is reported. To guarantee the detection quality and accuracy, an “OFF–ON” strategy is adopted: in the presence of albumin, the luminescence of nanoparticles remains suppressed owing to energy transfer to the quencher. Upon albumin binding to the antibody, the luminescence is recovered under near‐infrared light. In various bio‐samples, the UCNPs‐Ab‐RBHA (UCAR) nanoprobe can sense albumin with a broad detection range (5–315 ng mL−1). When applied to liver ductal organoid culture medium, the UCAR can monitor hepatocyte differentiation in real time by sensing the secreted albumin. Further, UCAR enables live imaging of cellular albumin in cells, organoids, and tissues. In a CCl4‐induced liver injury model, UCAR detects reduced albumin in liver tissue and serum. Thus, a biocompatible nanoprobe for both quantification and imaging of protein in complex biological environment with superior stability and high sensitivity is provided. Förster resonance energy transfer‐based UCNPs‐Ab‐RBHA (upconversion nanoparticles‐antibody‐rose bengal hexanoic acid, UCAR) nanoprobe adopts an “OFF–ON” strategy to detect target protein. Under near‐infrared light, UCAR nanoprobe enables protein quantification in vitro and target cell labeling in living cells, organoids, and mouse liver with superior stability and high sensitivity, showing great potential in protein/cell tracking in vivo and clinical diagnosis.
Author Wang, Jihua
Tian, Meng
Shen, Congcong
Wang, Zhenxing
Xu, Shicai
Lv, Enguang
Wei, Jinsong
Li, Xuewen
Zhao, Bing
Sun, Wan
Li, Xiaoyu
Tian, Shizheng
Liu, Guofeng
Li, Chonghui
AuthorAffiliation 3 Greater Bay Area Institute of Precision Medicine (Guangzhou) Fudan University Nansha District Guangzhou 511458 China
2 State Key Laboratory of Genetic Engineering School of Life Sciences Zhongshan Hospital Fudan University Shanghai 200438 China
1 Shandong Key Laboratory of Biophysics Institute of Biophysics College of Physics and Electronic Information Dezhou University Dezhou 253023 China
AuthorAffiliation_xml – name: 2 State Key Laboratory of Genetic Engineering School of Life Sciences Zhongshan Hospital Fudan University Shanghai 200438 China
– name: 1 Shandong Key Laboratory of Biophysics Institute of Biophysics College of Physics and Electronic Information Dezhou University Dezhou 253023 China
– name: 3 Greater Bay Area Institute of Precision Medicine (Guangzhou) Fudan University Nansha District Guangzhou 511458 China
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/35853243$$D View this record in MEDLINE/PubMed
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Keywords near-infrared-responded high sensitivity nanoprobe
mouse liver
living cell labeling
hepatic organoids
protein quantification and imaging
Language English
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2022 The Authors. Advanced Science published by Wiley-VCH GmbH.
This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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Snippet Exploring the advanced techniques for protein detection facilitates cell fate investigation. However, it remains challenging to quantify and visualize the...
Abstract Exploring the advanced techniques for protein detection facilitates cell fate investigation. However, it remains challenging to quantify and visualize...
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SubjectTerms Albumins
Animals
Antibodies
Biocompatibility
Biomarkers
hepatic organoids
Infrared Rays
Lasers
Ligands
Liver
living cell labeling
Mice
mouse liver
Nanoparticles
near‐infrared‐responded high sensitivity nanoprobe
Organoids
protein quantification and imaging
Proteins
Quantum dots
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Title Near‐Infrared‐Responded High Sensitivity Nanoprobe for Steady and Visualized Detection of Albumin in Hepatic Organoids and Mouse Liver
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