Constitutively Active TRPC Channels of Adipocytes Confer a Mechanism for Sensing Dietary Fatty Acids and Regulating Adiponectin

• Published in: Circulation research Vol. 111; no. 2; pp. 191 - 200
• Main Authors: Sukumar, Piruthivi, Sedo, Alicia, Li, Jing, Wilson, Lesley A., OʼRegan, David, Lippiat, Jonathan D., Porter, Karen E., Kearney, Mark T., Ainscough, Justin F.X., Beech, David J.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD American Heart Association, Inc 06.07.2012; Lippincott Williams & Wilkins
• Subjects: 3T3 Cells; Adipocytes - metabolism; Adipocytes - pathology; Adipocytes - physiology; Adiponectin - antagonists & inhibitors; Adiponectin - biosynthesis; Adiponectin - blood; Animals; Biological and medical sciences; Down-Regulation - physiology; Fatty Acids, Omega-3 - physiology; Fundamental and applied biological sciences. Psychology; HEK293 Cells; Humans; Inflammation Mediators - antagonists & inhibitors; Inflammation Mediators - blood; Inflammation Mediators - physiology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Organ Culture Techniques; Protein Multimerization - genetics; TRPC Cation Channels - physiology; Vertebrates: cardiovascular system; calcium channel; Adipocyte; adiponectin; Calcium; Lipids; Ionic channel; Inorganic element; Fatty acids; Transients; transient receptor potential; Vertebrata; Linolenic acid; Mammalia; TRP ion channel; α-linolenic acid; Essential fatty acid; Circulatory system; Biological receptor

RATIONALE:Calcium entry is pivotal in the heart and blood vessels, but its significance and mechanisms in adipose tissue are largely unknown. An important factor produced by adipocytes is adiponectin, which confers myocardial protection, insulin-sensitization, and antiatherosclerotic effects. OBJECT...