anti-inflammatory effects of interleukin-4 are not mediated by suppressor of cytokine signalling-1 (SOCS1)

• Published in: Immunology Vol. 131; no. 1; pp. 118 - 127
• Main Authors: Woodward, Eleanor A, Prêle, Cecilia M, Nicholson, Sandra E, Kolesnik, Tatiana B, Hart, Prue H
• Format: Journal Article
• Language: English
• Published: Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.09.2010; Blackwell Publishing Ltd; Wiley Subscription Services, Inc; Blackwell Science Inc
• Subjects: Animals; Anti-Inflammatory Agents - metabolism; Anti-Inflammatory Agents - pharmacology; Cells, Cultured; Cytokines; endotoxin/lipopolysaccharide; Humans; inflammation; Interferon-gamma - pharmacology; Interleukin-4 - metabolism; Interleukin-4 - pharmacology; Lipopolysaccharides - immunology; Lipopolysaccharides - pharmacology; Macrophages - drug effects; Macrophages - immunology; Macrophages - metabolism; macrophages/monocytes; Medical research; Mice; Mice, Inbred C57BL; Monocytes - drug effects; Monocytes - immunology; Monocytes - metabolism; Original; Proteins; RNA, Messenger - genetics; RNA, Messenger - metabolism; Rodents; Signal Transduction; signalling/signal transduction; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling Proteins - drug effects; Suppressor of Cytokine Signaling Proteins - genetics; Suppressor of Cytokine Signaling Proteins - metabolism; Tumor Necrosis Factor-alpha - metabolism

While it is known that the anti-inflammatory effects of interleukin (IL)-4 require new protein synthesis, the exact mechanisms by which IL-4 suppresses the production of pro-inflammatory cytokines by human monocytes and macrophages is unclear. IL-4 rapidly induced suppressor of cytokine signalling-1...