Dosing algorithms to predict warfarin maintenance dose in Caucasians and African Americans

• Published in: Clinical pharmacology and therapeutics Vol. 84; no. 3; p. 332
• Main Authors: Schelleman, H, Chen, J, Chen, Z, Christie, J, Newcomb, C W, Brensinger, C M, Price, M, Whitehead, A S, Kealey, C, Thorn, C F, Samaha, F F, Kimmel, S E
• Format: Journal Article
• Language: English
• Published: United States 01.09.2008
• Subjects: African Americans; Algorithms; Anticoagulants - administration & dosage; Anticoagulants - therapeutic use; Aryl Hydrocarbon Hydroxylases - genetics; Cytochrome P-450 CYP2C9; Drug Labeling; European Continental Ancestry Group; Female; Humans; International Normalized Ratio; Linear Models; Male; Middle Aged; Mixed Function Oxygenases - genetics; Polymorphism, Genetic; Predictive Value of Tests; Thromboembolism - drug therapy; Vitamin K Epoxide Reductases; Warfarin - administration & dosage; Warfarin - therapeutic use

The objective of this study was to determine whether warfarin dosing algorithms developed for Caucasians and African Americans on the basis of clinical, environmental, and genetic factors will perform better than an empirical starting dose of 5 mg/day. From April 2002 through December 2005, 259 subj...