Damage‐associated molecular pattern–activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury

• Published in: Hepatology (Baltimore, Md.) Vol. 62; no. 2; pp. 600 - 614
• Main Authors: Huang, Hai, Tohme, Samer, Al‐Khafaji, Ahmed B., Tai, Sheng, Loughran, Patricia, Chen, Li, Wang, Shu, Kim, Jiyun, Billiar, Timothy, Wang, Yanming, Tsung, Allan
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc 01.08.2015
• Subjects: Animals; Biomarkers - blood; Cells, Cultured; Disease Models, Animal; Extracellular Traps - immunology; Extracellular Traps - metabolism; Flow Cytometry; Fluorescent Antibody Technique; Hepatocytes - immunology; Hepatocytes - metabolism; Hepatology; Histones - metabolism; HMGB1 Protein - metabolism; Immunity, Innate - immunology; Immunoblotting; Inflammation - metabolism; Inflammation - physiopathology; Kupffer Cells - immunology; Kupffer Cells - metabolism; Liver; Liver - immunology; Liver - injuries; Liver - pathology; Male; Mice; Mice, Inbred C57BL; Molecular Biology; Neutrophils - immunology; Neutrophils - metabolism; Random Allocation; Rodents; Sensitivity and Specificity; Signal Transduction - genetics

Innate immunity plays a crucial role in the response to sterile inflammation such as liver ischemia/reperfusion (I/R) injury. The initiation of liver I/R injury results in the release of damage‐associated molecular patterns, which trigger an innate immune and inflammatory cascade through pattern rec...