Doppler ultrasound assessment of tumor vascularity in locally advanced breast cancer at diagnosis and following primary systemic chemotherapy

• Published in: Journal of pharmacy & bioallied science Vol. 15; no. 6; pp. 1280 - 1282
• Main Authors: Patel, Sanjaykumar, Nimavat, Keyur, Patel, Pragnesh, Kachhadia, Jenish
• Format: Journal Article
• Language: English
• Published: Mumbai Wolters Kluwer India Pvt. Ltd 01.07.2023; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: Breast cancer; Cancer; Chemotherapy; Diagnosis; Diagnostic imaging; Doppler effect; doppler ultrasound; locally advanced breast cancer; Medical diagnosis; Medical research; Medicine, Experimental; Metastases; Original; Patients; primary systemic chemotherapy; Tumors; Ultrasound imaging; primary systemic chemotherapy; locally advanced breast cancer; Doppler ultrasound
• DOI: 10.4103/jpbs.jpbs_121_23
• ISSN: 0975-7406; 0976-4879

Aim: The primary goal of this research is to compare the morphological response, as determined by clinical and sonographic examination, to the gold standard, histology, in assessing the effectiveness of major systemic chemotherapy in patients with locally advanced breast cancer (LABC). Materials and Methods: During the check and before each example of chemotherapy (FAC schedule), 54 patients with privately progressed, non-metastatic breast disease underwent a comprehensive clinical assessment, ultrasonography of the breast and axillae, and assortment and spooky Doppler appraisal to evaluate response to therapy. Results: In 90% of instances, Doppler provided early insight into how a patient might respond to treatment. Disappearance of all vascular signals inside the tumor was shown to be the strongest predictor of full pathological response. Conclusion: Patients with LABC may benefit from using color Doppler to determine how well chemotherapy is working.