Crx, a Novel Otx-like Paired-Homeodomain Protein, Binds to and Transactivates Photoreceptor Cell-Specific Genes

• Published in: Neuron (Cambridge, Mass.) Vol. 19; no. 5; pp. 1017 - 1030
• Main Authors: Chen, Shiming, Wang, Qing-Liang, Nie, Zuqin, Sun, Hui, Lennon, Gregory, Copeland, Neal G, Gilbert, Debra J, Jenkins, Nancy A, Zack, Donald J
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.1997
• Subjects: Amino Acid Sequence; Animals; Base Sequence; Cattle; Chromosome Mapping; Chromosomes, Human, Pair 19; Cloning, Molecular; Genes - physiology; Homeodomain Proteins - metabolism; Homeodomain Proteins - physiology; Humans; Mice; Molecular Sequence Data; Photoreceptor Cells - metabolism; Photoreceptor Cells - physiology; Pineal Gland - cytology; Pineal Gland - metabolism; Promoter Regions, Genetic - physiology; Retinitis Pigmentosa - genetics; Rhodopsin - genetics; Trans-Activators - metabolism; Trans-Activators - physiology; Transcriptional Activation - physiology

The otd/ Otx gene family encodes paired-like homeodomain proteins that are involved in the regulation of anterior head structure and sensory organ development. Using the yeast one-hybrid screen with a bait containing the Ret 4 site from the bovine rhodopsin promoter, we have cloned a new member of t...