Efficacy of an oral combination of afoxolaner and milbemycin oxime for the prevention of transmission of Babesia canis by Dermacentor reticulatus ticks to dogs

• Published in: Parasites & vectors Vol. 18; no. 1; p. 142
• Main Authors: Tielemans, Eric, Rautenbach, Carin, Viljoen, Alta, Beugnet, Frederic
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 15.04.2025; BioMed Central; BMC
• Subjects: acaricides; Acaricides - administration & dosage; Administration, Oral; adults; Afoxolaner; Animals; Arachnid Vectors - parasitology; Babesia; Babesia - drug effects; Babesia canis; babesiosis; Babesiosis - parasitology; Babesiosis - prevention & control; Babesiosis - transmission; blood; body temperature; class; Control; Dermacentor - drug effects; Dermacentor - parasitology; Dermacentor reticulatus; Disease transmission; Diseases; Dog; Dog Diseases - parasitology; Dog Diseases - prevention & control; Dog Diseases - transmission; Dogs; Europe; Female; insecticides; Isoxazoles - administration & dosage; Macrolides - administration & dosage; Male; Naphthalenes - administration & dosage; nematicides; polymerase chain reaction; Prevention of transmission; sex ratio; signs and symptoms (animals and humans); Tick Infestations - parasitology; Tick Infestations - veterinary; urine; Europe; Dermacentor reticulatus; Prevention of transmission; Afoxolaner; Babesia canis; Dog
• ISSN: 1756-3305; 1756-3305
• DOI: 10.1186/s13071-025-06787-y

Canine babesiosis is a tick-borne disease of significant veterinary importance in dogs. It is caused by Babesia canis in Europe, where it is transmitted by Dermacentor reticulatus ticks. A blinded, randomized, good clinical practice (GCP) and negative control experimental study was conducted to veri...