Differences in Resting-State Functional Magnetic Resonance Imaging Functional Network Connectivity Between Schizophrenia and Psychotic Bipolar Probands and Their Unaffected First-Degree Relatives

• Published in: Biological psychiatry (1969) Vol. 71; no. 10; pp. 881 - 889
• Main Authors: Meda, Shashwath A., Gill, Adrienne, Stevens, Michael C., Lorenzoni, Raymond P., Glahn, David C., Calhoun, Vince D., Sweeney, John A., Tamminga, Carol A., Keshavan, Matcheri S., Thaker, Gunvant, Pearlson, Godfrey D.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.05.2012; Elsevier
• Subjects: Adult; Adult and adolescent clinical studies; Biological and medical sciences; Bipolar; Bipolar Disorder - genetics; Bipolar Disorder - physiopathology; Brain - physiopathology; Case-Control Studies; default mode; Female; functional connectivity; Functional Neuroimaging; gene; Humans; Magnetic Resonance Imaging; Male; Medical sciences; Middle Aged; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Psychotic Disorders - physiopathology; relatives; resting state; Schizophrenia; Schizophrenia - genetics; Schizophrenia - physiopathology; Bipolar; default mode; resting state; functional connectivity; gene; schizophrenia; relatives; Family study; Schizophrenia; Genetic determinism; Psychosis; Rest; Gene; Functional magnetic resonance imaging; Genetics
• ISSN: 0006-3223; 1873-2402; 1873-2402
• DOI: 10.1016/j.biopsych.2012.01.025

Schizophrenia and bipolar disorder share overlapping symptoms and genetic etiology. Functional brain dysconnectivity is seen in both disorders. We compared 70 schizophrenia and 64 psychotic bipolar probands, their respective unaffected first-degree relatives (n = 70, and n = 52), and 118 healthy sub...