Semaphorin-3A Promotes Degradation of Fragile X Mental Retardation Protein in Growth Cones via the Ubiquitin-Proteasome Pathway

• Published in: Frontiers in neural circuits Vol. 14; p. 5
• Main Authors: Takabatake, Masaru, Goshima, Yoshio, Sasaki, Yukio
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 28.02.2020; Frontiers Media S.A
• Subjects: Animal behavior; Axon guidance; Axonal plasticity; Brain-derived neurotrophic factor; Dendritic spines; Experiments; FMR1 protein; fragile X mental retardation protein; Fragile X syndrome; growth cone; Growth cones; Hippocampus; Intellectual disabilities; Localization; Microtubule-associated protein 1; microtubule-associated protein 1B; Morphology; Neural networks; Neurons; Neuroscience; Phosphorylation; Proteasome inhibitors; Proteasomes; Proteins; Ribonucleic acid; RNA; RNA-binding protein; semaphorin; Semaphorins; Synaptic plasticity; Translation; Ubiquitin; Variance analysis; growth cone; semaphorin; proteasome; fragile X syndrome; fragile X mental retardation protein; axon guidance; microtubule-associated protein 1B; ubiquitin

Fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates local translation in dendrites and spines for synaptic plasticity. In axons, FMRP is implicated in axonal extension and axon guidance. We previously demonstrated the involvement of FMRP in growth cone collapse a tra...