Rabbit models for the study of human atherosclerosis: From pathophysiological mechanisms to translational medicine

• Published in: Pharmacology & therapeutics (Oxford) Vol. 146; pp. 104 - 119
• Main Authors: Fan, Jianglin, Kitajima, Shuji, Watanabe, Teruo, Xu, Jie, Zhang, Jifeng, Liu, Enqi, Chen, Y. Eugene
• Format: Journal Article
• Language: English
• Published: England 01.02.2015
• Subjects: Animals; Animals, Genetically Modified; Atherosclerosis - metabolism; Disease Models, Animal; Humans; Lipid Metabolism; Rabbits; Translational Medical Research; Experimental animal models; Hypercholesterolemia; Transgenic rabbits; Translational medicine; Atherosclerosis

Laboratory animal models play an important role in the study of human diseases. Using appropriate animals is critical not only for basic research but also for the development of therapeutics and diagnostic tools. Rabbits are widely used for the study of human atherosclerosis. Because rabbits have a...