Convalescent human plasma candidate reference materials protect against Crimean-Congo haemorrhagic fever virus (CCHFV) challenge in an A129 mouse model

• Published in: Virus research Vol. 346; p. 199409
• Main Authors: Kempster, Sarah, Hassall, Mark, Graham, Victoria, Kennedy, Emma, Findlay-Wilson, Stephen, Salguero, Francisco J., Bagci, Binnur, Elaldi, Nazif, Oz, Murtaza, Tasseten, Tuba, Charlton, Frank W., Barr, John N., Fontana, Juan, Duru, Chinwe, Ezeajughi, Ernest, Matejtschuk, Paul, Arnold, Ulrike, Adedeji, Yemisi, Mirazimi, Ali, Hewson, Roger, Dowall, Stuart, Almond, Neil
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2024; Elsevier
• Subjects: Animals; antibodies; Antibodies, Neutralizing - blood; Antibodies, Neutralizing - immunology; Antibodies, Viral - blood; Antibodies, Viral - immunology; blood; CCHF; CCHFV; Convalescent; Crimean-Congo hemorrhagic fever orthonairovirus; direct contact; Disease Models, Animal; Female; fever; glycoproteins; Hemorrhagic Fever Virus, Crimean-Congo - immunology; Hemorrhagic Fever, Crimean - immunology; Hemorrhagic Fever, Crimean - prevention & control; Humans; Immunity; immunogenicity; Infection; livestock; Male; Mice; Mouse model; neutralization; Neutralization Tests; nucleoproteins; pathogens; Plasma - immunology; protective effect; Vaccine; vaccine development; viruses; World Health Organization; Infection; CCHF; Convalescent; CCHFV; Mouse model; Vaccine; Immunity

•Convalescent human plasma can protect against CCHFV challenge in a mouse model.•The protection afforded by the convalescent plasma was titratable.•Defining the protective level of anti-CCHFV antibodies supports vaccine development. Crimean-Congo Haemorrhagic Fever Virus (CCHFV) is spread by infecte...